1,721,004 research outputs found
Code and data for estimation of parameters in mathematical models of myocyte action potentials
No full text<p>This is a suite of Python codes and data for estimation of parameters in mathematical models of myocyte action potentials.</p>
<p>The codes perform pre-processing of the data, statistical inference of parameter values in a mathematical model of action potential, and post-processing of results. </p>
<p>The data consist of experimentally recorded action potential wave forms of rabbit ventricular myocytes. The data is due to RJ Gilchrist [orcid.org/0000-0001-5003-4362], FL Burton [orcid.org/0000-0002-6970-6250], RC Myles [orcid.org/0000-0003-4670-361X] and GL Smith [orcid.org/0000-0003-4821-9741].</p>
<p>The mathematical model used is [doi.org/10.1529/biophysj.104.047449]. </p>
<p>The statistical inference method is based on a maximum-likelihood principle.</p>
<p>The code dependencies include standard Python libraries and the myokit [myokit.org] and pints [github.com/pints-team/pints]<br>packages. All dependencies are declared in the code by Python "import" statements. The code can be run as specified in the tcsh scripts "run_fit.sh" and "run_plot.sh".</p>
<p> </p><p>The code and data are associated with a resarch paper currently under review for publication in a scientific journal. The description will be updated accordingly at a later date.</p>
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
A study of global magnetic helicity in self-consistent spherical dynamos
Full text linkMagnetic helicity is a fundamental constraint in both ideal and resistive magnetohydrodynamics. Measurements of magnetic helicity density on the Sun and other stars are used to interpret the internal behaviour of the dynamo generating the global magnetic field. In this note, we study the behaviour of the global relative magnetic helicity in three self-consistent spherical dynamo solutions of increasing complexity. Magnetic helicity describes the global linkage of the poloidal and toroidal magnetic fields (weighted by magnetic flux), and our results indicate that there are preferred states of this linkage. This leads us to propose that global magnetic reversals are, perhaps, a means of preserving this linkage, since, when only one of the poloidal or toroidal fields reverses, the preferred state of linkage is lost. It is shown that magnetic helicity indicates the onset of reversals and that this signature may be observed at the outer surface
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Action potential propagation and block in a model of atrial tissue with myocyte-fibroblast coupling
Full text linkThe electrical coupling between myocytes and fibroblasts and the spacial distribution of fibroblasts within myocardial tissues are significant factors in triggering and sustaining cardiac arrhythmias, but their roles are poorly understood. This article describes both direct numerical simulations and an asymptotic theory of propagation and block of electrical excitation in a model of atrial tissue with myocyte–fibroblast coupling. In particular, three idealized fibroblast distributions are introduced: uniform distribution, fibroblast barrier and myocyte strait—all believed to be constituent blocks of realistic fibroblast distributions. Primary action potential biomarkers including conduction velocity, peak potential and triangulation index are estimated from direct simulations in all cases. Propagation block is found to occur at certain critical values of the parameters defining each idealized fibroblast distribution, and these critical values are accurately determined. An asymptotic theory proposed earlier is extended and applied to the case of a uniform fibroblast distribution. Biomarker values are obtained from hybrid analytical-numerical solutions of coupled fast-time and slow-time periodic boundary value problems and compare well to direct numerical simulations. The boundary of absolute refractoriness is determined solely by the fast-time problem and is found to depend on the values of the myocyte potential and on the slow inactivation variable of the sodium current ahead of the propagating pulse. In turn, these quantities are estimated from the slow-time problem using a regular perturbation expansion to find the steady state of the coupled myocyte–fibroblast kinetics. The asymptotic theory gives a simple analytical expression that captures with remarkable accuracy the block of propagation in the presence of fibroblasts
Quasi-geostrophic approximation of anelastic convection
Full text linkThe onset of convection in a rotating cylindrical annulus with parallel ends filled with a compressible fluid is studied in the anelastic approximation. Thermal Rossby waves propagating in the azimuthal direction are found as solutions. The analogy to the case of Boussinesq convection in the presence of conical end surfaces of the annular region is emphasised. As in the latter case, the results can be applied as an approximation for the description of the onset of anelastic convection in rotating spherical fluid shells. Reasonable agreement with three-dimensional numerical results published by Jones, Kuzanyan & Mitchell (J. Fluid Mech., vol. 634, 2009, pp. 291–319) for the latter problem is found. As in those results, the location of the onset of convection shifts outwards from the tangent cylinder with increasing number Nρof density scale heights until it reaches the equatorial boundary. A new result is that at a much higher number Nρ the onset location returns to the interior of the fluid shell
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