1,720,985 research outputs found
Adenosine Receptor mRNA Expression in Normal and Failing Minipig Hearts
No full textBackground: Chronic heart failure (HF) results in possibly beneficial endogenous adenosina accumulation. The final biological action of adenosine in a particular organ or cell population may depend on the relative expression level and signaling efficiency of the individual adenosine receptor (AR) subtypes.
Aim: To determine myocardial expression of ARs, in the different chambers of failing compared to normal minipig hearts.
Materials and Methods: Cardiac tissue (left and right atrium, left and right ventricle) was collected from male adult minipigs without (control, C, n=5) and with pacing-induced HF (n=5). ARs mRNA expression was evaluated by RT-PCR together with TNF– mRNA expression.
Results: A1R, A2AR, A2BR and A3R were expressed in all cardiac regions analyzed and, after 3 weeks of pacing, in left ventricle mRNA of each ARs resulted more expressed that in controls (A3R/gapdh: C=0.2±0.07 vs. HF: 1.4±0.5 p=0.03). TNF– mRNA expression resulted significantly higher in left ventricle of HF pig (p=0.009). We also observed a significant correlation between TNF– mRNA expression and A1R (r=0.6 p=0.0002), A2AR (r=0.8 p<0.0001), A2BR (r=0.9 p<0.0001), A3R (r=0.7 p<0.0001).
Conclusion: ARs mRNA espression were characterized simultaneously in all cardiac chambers of normal and HF animals. All ARs, and expecially AR3 subtype, are expressed in all cardiac chambers and, compared to controls, overexpressed in left ventricle
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Gli score clinici nell’insufficienza cardiaca cronica: esiste uno score ideale
No full textNumerous prognostic markers have shown to be predictive of patient outcome in heart failure (HF). The recent guidelines of the European Society of Cardiology for the diagnosis and treatment of acute and chronic HF have identified as many as 57 individual markers in patients with HF, including demographic data, etiology, comorbidities, clinical, radiological, hemodynamic, echocardiographic and biochemical parameters. If more accurate risk stratification is required, several scoring systems have been proposed. This article reviews scoring systems for HF prognostication. Although most of the models include readily available clinical information, usually NYHA functional class, left ventricular ejection fraction (LVEF) and comorbidities, quite a few of them comprise Doppler echocardiographic variables, other than LVEF, and circulating levels of natriuretic peptides. In order to achieve a better prediction of the outcome, an ideal score should be based on a comprehensive Doppler echocardiographic examination, the assessment of circulating biomarkers, and a more objective evaluation of exercise tolerance
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Adenosine Receptor mRNA Expression in Normal and Failing Minipig Hearts
No full textBackground: Chronic heart failure (HF) results in possibly beneficial endogenous adenosina accumulation. The final biological action of adenosine in a particular organ or cell population may depend on the relative expression level and signaling efficiency of the individual adenosine receptor (AR) subtypes.
Aim: To determine myocardial expression of ARs, in the different chambers of failing compared to normal minipig hearts.
Materials and Methods: Cardiac tissue (left and right atrium, left and right ventricle) was collected from male adult minipigs without (control, C, n=5) and with pacing-induced HF (n=5). ARs mRNA expression was evaluated by RT-PCR together with TNF– mRNA expression.
Results: A1R, A2AR, A2BR and A3R were expressed in all cardiac regions analyzed and, after 3 weeks of pacing, in left ventricle mRNA of each ARs resulted more expressed that in controls (A3R/gapdh: C=0.2±0.07 vs. HF: 1.4±0.5 p=0.03). TNF– mRNA expression resulted significantly higher in left ventricle of HF pig (p=0.009). We also observed a significant correlation between TNF– mRNA expression and A1R (r=0.6 p=0.0002), A2AR (r=0.8 p<0.0001), A2BR (r=0.9 p<0.0001), A3R (r=0.7 p<0.0001).
Conclusion: ARs mRNA espression were characterized simultaneously in all cardiac chambers of normal and HF animals. All ARs, and expecially AR3 subtype, are expressed in all cardiac chambers and, compared to controls, overexpressed in left ventricle.
Ref.:Picano E et al.Tips 1998; 19:14-16
Compensatory Adaptation of Left Ventricular Wall Stress in Response to Dyssynchrony Induced by Chronic Pacing in Minipigs
No full textEstimation of increased pulmonary wedge pressure by an algorithm based on noninvasively measured pulmonary diastolic pressure in cardiac patients independent of left ventricular ejection fraction
No full text- …
