471 research outputs found
Formation of a cohort of anticovid plasma donors with high-titer antibodies neutralizing SARS-CoV-2
No full textBackground. The application of convalescent plasma (CP) is currently seen as a feasible therapeutic approach in the treatment of COVID-19. Aim. To analyze the experience of recruiting a donor cohort from COVID-19 convalescents for banking of CP as part of a pilot project at the Moscow Healthcare Department. Materials and methods. A retrospective research included 493 COVID-19 convalescents as potential CP donors, all examined at the Sklifosovsky Research Institute for Emergency Medicine. CP was banked using the plasmapheresis method. Only those donors with a documented medical history of COVID-19, which was confirmed by polymerase chain reaction of SARS-CoV-2 RNA in pharyngeal swabs, and no sooner than 14 days after complete recovery were eligible for donation. Viral neutralizing activity (VNA) was chosen as the key characteristic of the immunological viability of CP. All the donors having VNA titers were characterized in terms of gender, age, time interval since the disease onset, regression of clinical symptoms and clinical features of the COVID 19 course. Results. Effective (1:160 or more) and acceptable (1:80) VNA titers were found in 21.1 % and 24.75 % of donors, respectively. Significant predictors for a donor having a high VNA titer included: male sex, age over 36 years and verified viral pneumonia. The absence of a significant body temperature response (38.5 °C) can be considered as a negative marker of a potential donor. © 2020 Izdatel'stvo Meditsina. All rights reserved
Bruno Alfieri, “The United States at the 24th Biennale”; Introduction to Carla Lonzi, “An Operative Category”; Introduction to Mario Diacono, “Matter-Destructure: Richard Serra, Bruce Nauan, Joseph Kosuth”; Introduction to Tommaso Trini, “Art thet is More Realistic than Reality”
No full textLa pubblicazione Hot Art, Cold War: Southern and Eastern European Writing on American Art 1945-1990, a cura di C. Hopkins, I.B. Whyte, include testi di critici di varie nazioni europee dedicati all’arte statunitense dal 1945 al 1990, che non erano mai stati tradotti in inglese, commentati da brevi introduzioni. L’autore dei testi introduttivi ai saggi ha selezionati anche i saggi.
Il testo The United States at the 24th Biennale (Gli Stati Uniti alla XXIV Biennale) di Bruno Alfieri pubblicato in “Arte Contemporanea”, ottobre 1948, è dedicato al Padiglione americano alla Biennale di Venezia del 1948; il testo An Operative Category (Una categoria operativa) di Carla Lonzi pubblicato in “Marcatrè”, n. 8-9-10, luglio-agosto-settembre 1964, è dedicato al new dada e alla pop art presentati alla Biennale di Venezia del 1964; il testo Matter-Destructure: Richard Serra, Bruce Nauman, Joseph Kosuth (Materia – Destruttura: Richard Serra, Bruce Nauman, Joseph Kosuth), di Mario Diacono pubblicato in “Collage, n. 9 dicembre 1970, è dedicato a tre importanti artisti americani di tendenza concettuale e processuale; il testo Art that is More Realistic than Reality” (Un’arte più realista della realtà) di Tommaso Trini pubblicato in “Corriere della Sera”, 19 settembre 1974, è una recensione della mostra tenutasi alla Rotonda della Besana e dedicata all’iperrealismo americano ed europeo.Hot Art, Cold War: Southern and Eastern European Writing on American Art 1945-1990, edited by C. Hopkins, I.B. Whyte, included text by art critics from several European Nations dedicated to the art in US since 1945 to 1990, never translated in English, analized in brief introductions. The author the introductions to the essays, has previously selected them.
The text The United States at the 24th Biennale by Bruno Alfieri, pubblished in “Arte Contemporanea”, October 1948, is dedicated to the American Pavillion at Venice Biennial 1948; the text An Operative Category by Carla Lonzi, pubblished in “Marcatrè”, no. 8-9-10, July-August-September 1964, is dedicated to new dada and to pop art, showed at Venice Biennial in 1964; the text Matter-Destructure: Richard Serra, Bruce Nauman, Joseph Kosuth by Mario Diacono, pubblished in “Collage, no. 9 dicembre 1970, is dedicated to three important American conceptual and processual artists; the text Art that is More Realistic than Reality”, by Tommaso Trini, pubblished in “Corriere della Sera”, September 19 ,1974, is a review of the exhivtion at Rotonda della Besana, Milan, dedicated to American and European hyperrealism
Гемостазиологический портрет множественной миеломы
No full textPATIENTS WITH MULTIPLE MYELOMA BECOME NOT RARE PATIENTS OF THE NTPHROLOGICAL CLINIC. CLOSE ATTENTION TO THE HEMOSTATIC SYSTEM IS CONSIDERED AS AN IMPORTANT ASPECT OF THEIR MANAGEMENT. MEANWHILE, THROMBOTIC AND HEMORRHAGIC PROBLEMS IN THIS CATEGORY OF PATIENTS ARE QUITE COMMON, AND CHARACTERIZED BY CLINICAL AND PATHOPHYSIOLOGICAL DIVERSITY. ACCORDINGLY, THEY REQUIRE AN INDIVIDUAL APPROACH, BASED ON A CAREFUL LABORATORY MONITORING.НЕРЕДКИМИ ПАЦИЕНТАМИ НЕФРОЛОГИЧЕСКОЙ КЛИНИКИ СТАНОВЯТСЯ БОЛЬНЫЕ МНОЖЕСТВЕННОЙ МИЕЛОМОЙ. ВАЖНЫМ АСПЕКТОМ ИХ ВЕДЕНИЯ СЧИТАЕТСЯ ПРИСТАЛЬНОЕ ВНИМАНИЕ К СИСТЕМЕ ГЕМОСТАЗА. МЕЖДУ ТЕМ ТРОМБОТИЧЕСКИЕ И ГЕМОРРАГИЧЕСКИЕ ПРОБЛЕМЫ У ДАННОЙ КАТЕГОРИИ БОЛЬНЫХ ВСТРЕЧАЮТСЯ ДОВОЛЬНО ЧАСТО, ХАРАКТЕРИЗУЮТСЯ КЛИНИЧЕСКИМ И ПАТОФИЗИОЛОГИЧЕСКИМ МНОГООБРАЗИЕМ. СООТВЕТСТВЕННО, ТРЕБУЮТ ИНДИВИДУАЛЬНОГО ПОДХОДА, ОСНОВАННОГО НА ПОЛНОЦЕННОМ ЛАБОРАТОРНОМ МОНИТОРИНГЕ
Гемостазиологический портрет множественной миеломы
No full textPATIENTS WITH MULTIPLE MYELOMA BECOME NOT RARE PATIENTS OF THE NTPHROLOGICAL CLINIC. CLOSE ATTENTION TO THE HEMOSTATIC SYSTEM IS CONSIDERED AS AN IMPORTANT ASPECT OF THEIR MANAGEMENT. MEANWHILE, THROMBOTIC AND HEMORRHAGIC PROBLEMS IN THIS CATEGORY OF PATIENTS ARE QUITE COMMON, AND CHARACTERIZED BY CLINICAL AND PATHOPHYSIOLOGICAL DIVERSITY. ACCORDINGLY, THEY REQUIRE AN INDIVIDUAL APPROACH, BASED ON A CAREFUL LABORATORY MONITORING.НЕРЕДКИМИ ПАЦИЕНТАМИ НЕФРОЛОГИЧЕСКОЙ КЛИНИКИ СТАНОВЯТСЯ БОЛЬНЫЕ МНОЖЕСТВЕННОЙ МИЕЛОМОЙ. ВАЖНЫМ АСПЕКТОМ ИХ ВЕДЕНИЯ СЧИТАЕТСЯ ПРИСТАЛЬНОЕ ВНИМАНИЕ К СИСТЕМЕ ГЕМОСТАЗА. МЕЖДУ ТЕМ ТРОМБОТИЧЕСКИЕ И ГЕМОРРАГИЧЕСКИЕ ПРОБЛЕМЫ У ДАННОЙ КАТЕГОРИИ БОЛЬНЫХ ВСТРЕЧАЮТСЯ ДОВОЛЬНО ЧАСТО, ХАРАКТЕРИЗУЮТСЯ КЛИНИЧЕСКИМ И ПАТОФИЗИОЛОГИЧЕСКИМ МНОГООБРАЗИЕМ. СООТВЕТСТВЕННО, ТРЕБУЮТ ИНДИВИДУАЛЬНОГО ПОДХОДА, ОСНОВАННОГО НА ПОЛНОЦЕННОМ ЛАБОРАТОРНОМ МОНИТОРИНГЕ
Preservative-free IOP-lowering medications: potential advantages
No full text
I.B. Alekseev1, I.A. Koroleva2
1Russian Medical Academy of Continuous Professional Education, Moscow, Russian Federation
2City Clinical Hospital No. 15, Moscow, Russian Federation
According to the World Health Organization, glaucoma is the second leading cause of blindness in the world. Pharmacotherapy for glaucoma implies long-term instillations of IOP-lowering drugs. However, more glaucoma medications per day are required with time. In these cases, fixed-dose combinations containing several active ingredients are beneficial. Potential advantages of fixed-dose combinations include reduced costs, lower risk of washout, less instillations, reduced medication regimen complexity, and saved time. This results in better treatment compliance. Reduced preservative exposure is important as well. Many studies have demonstrated that preservatives induce local adverse reactions. Elimination or minimization of adverse reactions accompanying long-term glaucoma therapy is an important resource to improve treatment compliance and, therefore, to prevent vision loss and to maintain the quality of life. Hence, glaucoma patients may benefit from the avoidance of the addit ional risk of ocular surface disorders resulting from preservative exposure.
Keywords: glaucoma, intraocular pressure, monotherapy, combined treatment, fixed-dose combinations, prostaglandin analogues, ocular surface, compliance, tafluprost, Tapticom.
For citation: Alekseev I.B., Koroleva I.A. Preservative-free IOP-lowering medications: potential advantages. Russian Journal of Clinical Ophthalmology. 2019;19(3):137–142.
About the authors:
1Igor B. Alekseev — MD, PhD, Professor, ORCID iD 0000-0002-4506-4986;
2Irina A. Koroleva — MD, PhD, ophthalmologist, ORCID iD 0000-0003-1679-5701.
1Russian Medical Academy of Continuous Professional Education. 2/1, Barrikadnaya str., Moscow, 125993, Russian Federation.
2City Clinical Hospital No. 15. 23, Veshnyakovskaya str., Moscow, 111539, Russian Federation.
Contact information: Irina A. Koroleva, e-mail: [email protected]. Financial Disclosure: no author has a financial or property interest in any material or method mentioned. There is no conflict of interests. Received 24.06.2019.
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A letter to the author of the pamphlet called An answeer [sic] to the Hampshire narrative. : [Three lines from Proverbs]
No full text[4], 84, p. ; 19 cm. (8vo)Half-title: A letter to the author of the answer to the Hampshire narrative.Attributed to Jonathan Edwards by Johnson.Printer's mongram device with initials I.B. on title page; printer unknown.With an errata slip mounted on p. 84 in some copies
Adapting authoritarianism: institutions and co-optation in Egypt and Syria
No full textThis PhD thesis compares Egypt and Syria’s authoritarian political systems. While the tendency in social science political research treats Egypt and Syria as similarly authoritarian, this research emphasizes differences between the two systems with special reference to institutions and co-optation. Rather than reducibly understanding Egypt and Syria as sharing similar histories, institutional arrangements, or ascribing to the oft-repeated convention that “Syria is Egypt but 10 years behind,” this thesis focuses on how events and individual histories shaped each states current institutional strengthens and weaknesses. Specifically, it explains the how varying institutional politicization or de-politicization affects each state’s capabilities for co-opting elite and non-elite individuals.
Beginning with a theoretical framework that considers the limited utility of democratization and transition theoretical approaches, the work underscores the persistence and durability of authoritarianism. Chapter two details the politicized institutional divergence between Egypt and Syria that began in the 1970s. Chapter three and four examines how institutional politicization or de-politicization affects elite and non-elite individual co-optation in Egypt and Syria. Chapter five discusses the study’s general conclusions and theoretical implications.
This thesis’s argument is that Egypt and Syria co-opt elites and non-elites differently because of the varying degrees of institutional politicization in each governance system. Rather than view one country as more politically developed than the other, this work argues that Syria’s political institutions are more politicized than their Egyptian counterparts. Syria’s political arena is, thus, described as politicized-patrimonialism. Syria’s politicized-patrimonial arena produces uneven co-optation of elites and non-elites as they are diffused through competing institutions. Conversely, the Egyptian political arena remains highly personalized as weak institutions and individuals are manipulated and molded according to the president’s ruling clique. This is referred to as personalized-patrimonialism. As a consequence, Egypt’s political establishment demonstrates more flexibility in ad hoc altering and adapting its arena depending on the emergence of crises.
This study’s theoretical implications suggest that, contrary to modernization and democratization theory’s adage that institutions lead to a political development, politicized institutions within a patrimonial order actually hinder regime adaptation because consensus is harder to achieve and maintain. It is within this context that Egypt’s de-politicized institutional framework advantages its top political elite. In this reading of Egyptian and Syrian politics, Egypt’s personalized political arena is more adaptable than Syria’s. These conclusions do not indicate that political reform is a process underway in either state
ОПЫТ ПРИМЕНЕНИЯ КОНЦЕНТРАТА АНТИТРОМБИНА В МНОГОПРОФИЛЬНОЙ КЛИНИКЕ
No full textThrombosis and thromboembolism are one of the frequent serious and complications in all groups of patients and can lead to death. The purpose of our study was to analyze the clinical situations that required the use of antithrombin concentrate in the practice of intensive care units within the framework of a multidisciplinary hospital. A retrospective analysis was performed of the treatment of 38 patients with acquired antithrombin deficiency in 2016, which was treated with antithrombin. The analysis of the clinical situations that required the use of antithrombin concentrate revealed that the most frequent need for the use of the drug occurs in patients with malignant blood diseases, liver and kidney diseases and in patients with sepsis. Also, the calculation methods for determining the required dosage do not provide an optimal level of AT activity, and the efficacy of anticoagulant therapy does not depend on the total dosage of the drug administered.Тромбозы и тромбоэмболии являются одной из частых и грозных проблем, встречающихся практически у всех категорий пациентов как в отделениях интенсивной терапии, так и в стационарных отделениях многопрофильной клиники. Целью исследования явился анализ клинических ситуаций, потребовавших применения концентрата антитромбина (АТ) в рамках практики отделений реанимации и интенсивной терапии многопрофильного стационара. Был проведен ретроспективный анализ историй болезни 38 пациентов с приобретенным дефицитом АТ за 2016 г., которым проводилась заместительная терапия. При проведении анализа клинических ситуаций, потребовавших применения концентрата АТ, было выявлено, что наиболее часто необходимость введения препарата АТ возникает у пациентов со злокачественными заболеваниями крови, тромбозами и у пациентов с сепсисом. При этом расчетные методики определения необходимой дозировки не обеспечивают получения оптимального уровня активности АТ, а конечная эффективность антикоагулянтной терапии не зависит от суммарной дозировки вводимого препарата
Fabrication of nitinol nanoparticle using pulsed laser ablation
No full textThis paper consists of the study of the fabrication of Nano material of the Shape memory alloy NiTinol. A
detailed examination is done on the impact of test conditions on the properties of Ni-Ti nanoparticles created by
nanosecond laser ablation of NiTinol target. The paper likewise incorporates the basic circulation of the lighted surface.
The laser wavelengths utilized were 248nm for KrF laser and 1064 nm for Q-exchanged Nd:YAG laser. Nitinol targets
were inundated in mediums like refined water and ethanol. The examples were illuminated with pulses from both the
lasers. 500 pulses were utilized for the investigation of the surface of the objective and 20000 pulses for the molecule age.
The fluences utilized were 2 and 5 J/cm2 individually. Scanning Electron Microscope (SEM) was utilized to think about
the morphology of laser treated NiTi surface and the measure of the produced nanoparticles. Component mapping was
considered through vitality dispersive X-beam spectroscopy (EDX). The outcomes got, was that the ethanol based trial
demonstrates a relative homogeneous natural conveyance in both the laser treated NiTinol surface and the created
nanoparticles. While in refined water inundation, isolate nearness of Nickel and Titanium components was seen on the
illuminated surface and also the produced nanoparticles
ОПЫТ ПРИМЕНЕНИЯ КОНЦЕНТРАТА АНТИТРОМБИНА В МНОГОПРОФИЛЬНОЙ КЛИНИКЕ
No full textThrombosis and thromboembolism are one of the frequent serious and complications in all groups of patients and can lead to death. The purpose of our study was to analyze the clinical situations that required the use of antithrombin concentrate in the practice of intensive care units within the framework of a multidisciplinary hospital. A retrospective analysis was performed of the treatment of 38 patients with acquired antithrombin deficiency in 2016, which was treated with antithrombin. The analysis of the clinical situations that required the use of antithrombin concentrate revealed that the most frequent need for the use of the drug occurs in patients with malignant blood diseases, liver and kidney diseases and in patients with sepsis. Also, the calculation methods for determining the required dosage do not provide an optimal level of AT activity, and the efficacy of anticoagulant therapy does not depend on the total dosage of the drug administered.Тромбозы и тромбоэмболии являются одной из частых и грозных проблем, встречающихся практически у всех категорий пациентов как в отделениях интенсивной терапии, так и в стационарных отделениях многопрофильной клиники. Целью исследования явился анализ клинических ситуаций, потребовавших применения концентрата антитромбина (АТ) в рамках практики отделений реанимации и интенсивной терапии многопрофильного стационара. Был проведен ретроспективный анализ историй болезни 38 пациентов с приобретенным дефицитом АТ за 2016 г., которым проводилась заместительная терапия. При проведении анализа клинических ситуаций, потребовавших применения концентрата АТ, было выявлено, что наиболее часто необходимость введения препарата АТ возникает у пациентов со злокачественными заболеваниями крови, тромбозами и у пациентов с сепсисом. При этом расчетные методики определения необходимой дозировки не обеспечивают получения оптимального уровня активности АТ, а конечная эффективность антикоагулянтной терапии не зависит от суммарной дозировки вводимого препарата
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