649 research outputs found
“Survival – to keep writing”: An interview with Shirley Geok-lin Lim
No full textIn this e-mail interview conducted in 2016, author and scholar Shirley Geok-lin Lim addresses the changing social and political conditions in the United States. Lim discusses the affective relationship between aesthetics and politics in her work, the anxiety of multilingual stylistics, and the in-between nature of the transnation. She also reflects on the academic marginalization she has experienced as a result of her immigrant designation and subjectivity, as well as the indirect influence of China and Chineseness on her writing. Commenting on her memoir Among the White Moon Faces, Lim notes the difficulty of titling, and addresses the impact of anglophone literature upon her during her colonial Malaysian upbringing
“Survival -- to keep writing”: an interview with Shirley Geok-lin Lim
No full textIn this e-mail interview conducted in 2016, author and scholar Shirley Geok-lin Lim addresses the changing social and political conditions in the United States. Lim discusses the affective relationship between aesthetics and politics in her work, the anxiety of multilingual stylistics, and the in-between nature of the transnation. She also reflects on the academic marginalization she has experienced as a result of her immigrant designation and subjectivity, as well as the indirect influence of China and Chineseness on her writing. Commenting on her memoir Among the White Moon Faces, Lim notes the difficulty of titling, and addresses the impact of anglophone literature upon her during her colonial Malaysian upbringing
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'cultivated, / Wild, exotic': Nationalism and Internationalism in the Poetry of Shirley Geok-lin Lim
No full textBorn in multicultural Malacca during British rule, educated there and later in Kuala Lumpur and Boston, a long-time resident of the USA and a visiting professor to many countries, Shirley Geok-lin Lim seems a transnational writer par excellence. Yet much of her later work involves looking back to Malacca, “at a loss here, / Loosening my grip on yesterday,” afraid of losing “[s]hades of father and mother.” She is the author of poems, short stories, novels and a memoir, as well as literary and social criticism. The memoir, Among the White Moon Faces , is subtitled, “An Asian-American Memoir of Homelands,” and the plural noun is notable. Concentrating on her poetry, this paper charts her shifting sense of identity as Malaccan, Malaysian, American and as a woman of Chinese heritage whose language is English, through “[s]peech which is sufficient enterprise,” even though in these late poems she can feel “unmoored” and sense “the gravity / of the unmade I.
Evidence for a retroviral insertion in TRPM1 as the cause of congenital stationary night blindness and leopard complex spotting in the horse
No full textLeopard complex spotting is a group of white spotting patterns in horses caused by an incompletely dominant gene (LP) where homozygotes (LP/LP) are also affected with congenital stationary night blindness. Previous studies implicated Transient Receptor Potential Cation Channel, Subfamily M, Member 1 (TRPM1) as the best candidate gene for both CSNB and LP. RNA-Seq data pinpointed a 1378 bp insertion in intron 1 of TRPM1 as the potential cause. This insertion, a long terminal repeat (LTR) of an endogenous retrovirus, was completely associated with LP, testing 511 horses (χ²=1022.00, p<<0.0005), and CSNB, testing 43 horses (χ2=43, p<<0.0005). The LTR was shown to disrupt TRPM1 transcription by premature poly-adenylation. Furthermore, while deleterious transposable element insertions should be quickly selected against the identification of this insertion in three ancient DNA samples suggests it has been maintained in the horse gene pool for at least 17,000 years. This study represents the first description of an LTR insertion being associated with both a pigmentation phenotype and an eye disorder.Rebecca R. Bellone … David L. Adelson, Sim Lin Lim … et al
High Responsivity and Response Speed Single‐Layer Mixed‐Cation Lead Mixed‐Halide Perovskite Photodetectors Based on Nanogap Electrodes Manufactured on Large‐Area Rigid and Flexible Substrates
No full textAdv. Funct. Mater. 2019, 29, 1901371 In the initially published version of this article, the name of Akmaral Seitkhan was omitted from the final authors list. The correct author list is as follows: Dimitra G. Georgiadou,* Yen-Hung Lin, Jongchul Lim, Sinclair Ratnasingham, Akmaral Seitkhan, Martyn A. McLachlan, Henry J. Snaith, and Thomas D. Anthopoulos* The respective updated author affiliations are as follows: Dr. D. G. Georgiadou, Prof. T. D. Anthopoulos Department of Physics and Centre for Plastic Electronics Blackett Laboratory Imperial College London Exhibition Road, London SW7 2BW, UK E-mail: [email protected]; [email protected] Dr. D. G. Georgiadou, S. Ratnasingham, Dr. M. A. McLachlan Department of Materials and Centre for Plastic Electronics Imperial College London Prince Consort Road, London SW7 2BP, UK Dr. Y.-H. Lin, Dr. J. Lim, Prof. H. J. Snaith Department of Physics University of Oxford Clarendon Laboratory Parks Road, Oxford OX1 3PU, UK A. Seitkhan, Prof. T. D. Anthopoulos Division of Physical Sciences and Engineering King Abdullah University of Science and Technology (KAUST) Thuwal 23955–6900, Saudi Arabia The authors apologize for any inconvenience this error may have caused.</p
Robot Citizenship: A Design Perspective
No full textThis paper suggests robot citizenship as a design perspective for attending to the sociality of human robot interactions (HRI) in the near future. First, we review current positions regarding robot citizenship, which we summarise as: human analogy, nonhuman analogy and socio-relationality. Based on this review, we then suggest an understanding of citizenship that stresses the socio-relational implications of the concept, and in particular its potential for rethinking the way we approach the design of robots in practice. We suggest that designing for robot citizenship (in the terms suggested by this paper) has the potential of fostering a shift from a logic of functionality to one of relationality. To illuminate the direction of this shift in design practice, we include and discuss three robot concepts designed to address and rethink present HRI challenges in the urban environment from a relational perspective.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Human Information Communication DesignDesign Conceptualization and Communicatio
Corporate focus, aftermarket returns & earnings management : a study on IPO firms.
No full textIn this paper, we examine the relation between the degree of business complexity and the level of earnings management. We study firms that have issued initial public offerings from 1993 to 1998. Our analysis indicates that greater corporate diversification is associated with an increased level of discretionary accruals
Identification and annotation of recombinant repeats in mammals indicates they are experimental products for creating novel transposable element families.
No full textAbout 40-50% of mammalian genomes are made up of repetitive elements, primarily transposable elements. Transposable elements' activities not only drive genome evolution, they contribute to the creation of novel recombinant repeats. Recombinant repeats have largely remained uncharacterized due to their complexity. Initially, I developed a pipeline for the genome wide identification of recombinant repeats in four different mammals: human, mouse, cow and horse. The pipeline identified 1,336,824 copies, but only 37,830 sequences were able to be clustered into 6,116 families. The majority of the recombinant repeats were simple recombinant repeat families and only a small proportion were complex recombinant repeat families. My analysis showed that recombinant repeat families only covered a small fraction of the genomes examined (0.30% in human, 0.13% in mouse, 0.217% in horse and 0.464% in cow), indicating most of the recombinant repeats were singletons. Further analysis has shown that both classes of RR were created via transposon-into-transposon events, indicating that novel transposable elements are likely to be created via this mechanism. I found that simple recombinant repeats were probably retrotranspositionally active because they contained polyA tails and target site duplications, showing that they integrated into the genome via retrotransposition events. However, complex recombinant repeat families were only replicated via segmental duplications. My analysis showed that complex recombinant repeat families are excellent candidates for the identification of genome segmental duplication regions that cannot be found through standard methods. In addition, I used the RR identification pipeline to annotate possible RR in pig genome. I discovered a novel RR family (LTR2i_SS) that contained > 1,000 copies. Repeat annotation showed that it was a chimeric LTR2_SS that contained ~300bp of un-annotated sequence, only found in the pig genome. Further investigation revealed that some LTR2i_SS flanked β3 proviruses, but these proviruses were unable to replicate autonomously as they did not encode a functional, complete polyprotein. My phylogenetic tree analysis of the LTR2i_SS and LTR2_SS familis suggested that LTR2i_SS was the ancestral form of LTR2_SS. In conclusion, I was able to identify the recombinant repeat distributions in different mammals and determine their most probable origin as TinT events. I have shown that recombinant repeats could serve as an important model to explain the origin of novel transposable elements in genomes, or could be used as markers to identify structural variations, or segmental duplications in different species. However, my data have also shown that we have to be cautious when annotating novel recombinant repeats in genomes, as they could be the ancestral form of other known transposable elements rather than novel forms generated through TinT.Thesis (Ph.D.) -- University of Adelaide, School of Molecular and Biomedical Science, 201
Renorming of ℓ1 and the fixed point property
No full textAbstractFor any k∈N, let Pk denote the natural projections on ℓ1. Let |||⋅||| be an equivalent norm of ℓ1 that satisfies all of the following four conditions:(1)There are α>4 and a positive (decreasing) sequence (αn) in (0,1) such that for any normalized block basis {fn} of (ℓ1,|||⋅|||) and x∈ℓ1 with Pk−1(x)=x and |||x|||<αk,lim supn→∞|||fn+x|||⩽1+|||x|||α.(2)There are two strictly decreasing sequences {βk} and {γk} withlimk→∞βk=0andlimk→∞γk=1 such that for any normalized block basis {fn} of (ℓ1,|||⋅|||) and x with (I−Pk)(x)=x,lim infn→∞|||fn+x|||⩾1−βk+γk−1|||x|||.(3)For any k∈N, ‖I−Pk‖=1.(4)The unit ball of (ℓ1,|||⋅|||) is σ(ℓ1,c0)-closed. In this article, we prove that the space (ℓ1,|||⋅|||) has the fixed point property for the nonexpansive mapping. This improves a previous result of the author
[[alternative]]Correction to "Synergistic Inhibition of SARS-CoV-2 Replication Using Disulfiram/Ebselen and Remdesivir"
No full text[[abstract]]In the original manuscript, the authors Jian-Jong Liang, Chun-Che Liao, and Yi-Ling Lin were not listed. These three authors had performed the cell-based experiments in Figure 5b,c but were mistakenly listed in the acknowledgment section. The author list and affiliations should appear as in this Correction
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