1,720,964 research outputs found
Educação fundamental: as perspectivas dos professores diante das dificuldades de aprendizagem na escola José Neves de Castro – Acarape – CE
Get PDFSILVA, Fernanda Marques Da. Educação fundamental: as perspectivas dos professores diante das dificuldades de aprendizagem na escola José Neves de Castro – Acarape – CE. 22 f. Projeto de pesquisa (Graduação) - Curso de Graduação presencial, bacharelado em Humanidades. Instituto de Instituto de Humanidades (IH), Universidade da Integração Internacional da Lusofonia Afro-Brasileira. Redenção, 2020O presente projeto propõe um estudo sobre as perspectivas dos professores (especificamente do 2º ano do ensino Fundamental na Escola José Neves de Castro, no município de Acarape CE) sobre as dificuldades de aprendizagem de seus alunos. Com isso indico a realização de entrevistas com os professores afim de obter informações necessárias para descrever as dificuldades existente e entender seus desafios diante dessas realidades e quais as práticas realizadas. Pois a intenção é discutir soluções que minimizem as consequências provenientes dessas dificuldades, como por exemplo fracassos nas aprovações e possíveis evasões
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Análise da infecção in vitro e in vivo pelo Zika vírus no desenvolvimento de doenças cardiovasculares
No full textO Zika vírus (ZIKV) é conhecido por sua relação com complicações neurológicas, entretanto, estudos recentes também indicam que o ZIKV pode estar relacionado com o desenvolvimento de doenças cardiovasculares. Diante do aumento do número de relatos de casos de pacientes com complicações cardíacas após a infecção por ZIKV, se faz necessário estudos experimentais que busquem investigar esta associação. O objetivo deste estudo foi avaliar os efeitos da infecção pelo ZIKV, in vitro, in vivo e in silico no desenvolvimento de doenças cardiovasculares. No estudo in vitro células H9c2 e A7r5 foram infectadas com o ZIKV de origem brasileira, utilizando multiplicidade de infecção (MOI) de 1; 0,1 e 0,01. As células infectadas foram observadas diariamente em microscópio óptico para verificação de efeito citopático (ECP). A cada 24h pós-infecção, durante um período de 4 dias, os cultivos infectados foram congelados, descongelados e aliquotados para posterior análise de genoma viral por qPCR e titulação viral. Para análise da viabilidade celular foi realizado o teste de atividade da lactato desidrogenase (LDH) e para estresse oxidativo foi analisada a proteína carbonil e redução de NBT. No experimento in vivo, camundongos fêmeas FVB/N (n=8), com idade de 60 dias, foram inoculados com 1x10⁵ UFP de ZIKV via intravenosa. Após 4 dias de infecção, foi realizada coleta de sangue e tecido cardíaco para análise de troponina T, atividade enzimática de fatores de coagulação, aminopeptidases e análise de estresse oxidativo. Foi realizada análise estatística univariada através do teste t e ANOVA. Ainda, correlacionamos genes listados na Zika Virus Infection Database (ZIKAVID) aos genes ligados ao estresse oxidativo da Mouse Genome Database (MGD) a fim de verificar associação entre doenças cardíacas, estresse oxidativo e o ZIKV. As linhagens celulares apresentaram ECP característico de infecção viral e o RNA genômico foi detectado em todos os períodos analisados. A linhagem H9c2 produziu uma quantidade de vírus significativamente superior à A7r5 e analisando o estresse oxidativo após infecção, verifica-se que os níveis médios de conteúdo carbonil foram significativamente maiores nas linhagens celulares infectadas. Já in vivo, nas fêmeas infectadas houve um aumento significativo de troponina T quando comparado ao grupo controle. Ainda, observou-se um aumento significativo da atividade de enzimas fibrinolíticas e níveis elevados das aminopeptidases. Também, os resultados demonstraram alto índice de estresse oxidativo no tecido cardíaco de camundongos infectados. Conclui-se que além da suscetibilidade celular ao ZIKV, animais imunocompetentes infectados apresentam marcador de injúria celular elevado com ativação de enzimas pró-coagulantes e uma regulação negativa da fibrinólise, o que provavelmente indica um estado pró- trombótico nesses animais, evidenciando uma associação entre o vírus e complicações cardíacas.The Zika virus (ZIKV) is known for its relationship with neurological complications, however, recent studies also indicate that ZIKV may be related to the development of cardiovascular diseases. In view of the increasing number of case reports of patients with cardiac complications after ZIKV infection, experimental studies are needed to investigate this association. The aim of this study was to evaluate the effects of ZIKV infection, in vitro, in vivo and in silico on the development of cardiovascular diseases. In the in vitro study, H9c2 and A7r5 cells were infected with ZIKV of brazilian origin, using a multiplicity of infection (MOI) of 1; 0.1 and 0.01. Infected cells were observed daily under an optical microscope to verify the cytopathic effect (CPE). Every 24h post-infection, during a period of 4 days, the infected cultures were frozen, thawed and aliquoted for subsequent analysis of the viral genome by qPCR and viral titration. For cell viability analysis, the lactate dehydrogenase (LDH) activity test was performed and for oxidative stress, carbonyl protein and NBT reduction were analyzed. In the in vivo experiment, female FVB/N mice (n=8), aged 60 days, were inoculated with 1x10⁵ PFU of ZIKV intravenously. After 4 days of infection, blood and cardiac tissue were collected for analysis of troponin T, enzymatic activity of clotting factors, aminopeptidases, analysis of oxidative stress. Univariate statistical analysis was performed using the t test and ANOVA. Furthermore, we correlated genes listed in the Zika Virus Infection Database (ZIKAVID) with genes linked to oxidative stress from the Mouse Genome Database (MGD) in order to verify an association between heart disease, oxidative stress and ZIKV. The cell lines showed CPE characteristic of viral infection and genomic RNA was detected in all analyzes periods. The H9c2 cells produced a significantly higher amount of virus than A7r5 and analyzing the oxidative stress after infection, it appears that the average levels of carbonyl content were significantly higher in the infected cell lines. In vivo, in infected females, there was a significant increase in troponin T when compared to the control group. Furthermore, there was a significant increase in the activity of fibrinolytic enzymes and high levels of aminopeptidases. Also, the results showed a high rate of oxidative stress in the heart tissue of infected mice. It is concluded that in addition to cellular susceptibility to ZIKV, infected immunocompetent animals have a high marker of cell injury with activation of procoagulant enzymes and a negative regulation of fibrinolysis, which probably indicates a prothrombotic state in these animals, evidencing an association between the virus and heart complications
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Educação e tecnologias refletindo do conceito à ação
Get PDFA primeira parte do trabalho aborda as tecnologias sob a perspectiva histórica traçando um panorama da sua evolução. No segundo momento retoma sua trajetória na educação, evidenciando um pouco do seu percurso no mundo e, principalmente no Brasil, evidenciando pontos positivos e negativos, e por fim apresenta-se um relato de prática educativa em escola pública com o uso das tecnologia
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
- …
