1,720,966 research outputs found

    Nitrofurantoin and Fosfomycin Susceptibility Among Outpatient Uropathogens in a Tertiary Care Center in Southern Thailand

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    Objective: To document susceptibility to fosfomycin and nitrofurantoin among uropathogens isolated from the Out Patient Department and Emergency Room of Songklanagarind Hospital.Material and Methods: From October 2011 to May 2012, bacteria isolated from urine specimens of outpatients with pyuria were evaluated for susceptibility to nitrofurantoin and fosfomycin. The medical records of the patients were reviewed for uropathogens and other antimicrobial susceptibilities. The urinary tract infections (UTIs) were classified into complicated and uncomplicated. Factors associated with fosfomycin and nitrofurantoin susceptibilities were also studied.Results: The study included 324 patients with positive urine cultures. Complicated UTIs and uncomplicated UTIs were found in 72.8% and 27.2%, respectively. The most common causative uropathogen was Escherichia coli (E. coli) (71.9%) followed by Klebsiella pneumoniae (16.7%). The susceptibility of E. coli to fosfomycin was 98.7%, and the susceptibilities of E. coli, K. pneumoniae, and overall pathogens to nitrofurantoin were 91.0%, 24.1% and 74.1% respectively. Conclusion: The uropathogens in Songklanagarind Hospital have higher susceptibilities to fosfomycin than to nitrofurantoin.</jats:p

    Nitrofurantoin and Fosfomycin Susceptibility Among Outpatient Uropathogens in a Tertiary Care Center in Southern Thailand

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    Objective: To document susceptibility to fosfomycin and nitrofurantoin among uropathogens isolated from the Out Patient Department and Emergency Room of Songklanagarind Hospital.Material and Methods: From October 2011 to May 2012, bacteria isolated from urine specimens of outpatients with pyuria were evaluated for susceptibility to nitrofurantoin and fosfomycin. The medical records of the patients were reviewed for uropathogens and other antimicrobial susceptibilities. The urinary tract infections (UTIs) were classified into complicated and uncomplicated. Factors associated with fosfomycin and nitrofurantoin susceptibilities were also studied.Results: The study included 324 patients with positive urine cultures. Complicated UTIs and uncomplicated UTIs were found in 72.8% and 27.2%, respectively. The most common causative uropathogen was Escherichia coli (E. coli) (71.9%) followed by Klebsiella pneumoniae (16.7%). The susceptibility of E. coli to fosfomycin was 98.7%, and the susceptibilities of E. coli, K. pneumoniae, and overall pathogens to nitrofurantoin were 91.0%, 24.1% and 74.1% respectively. Conclusion: The uropathogens in Songklanagarind Hospital have higher susceptibilities to fosfomycin than to nitrofurantoin.</jats:p

    G-control Charts for Contamination Rates of Blood Cultures in a University Hospital

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    Objective: To determine blood culture contamination rates, and display with a g-chart. Materials and Methods: The medical records of patients, from whom blood cultures were obtained in a university hospital, during January and December 2019 were retrieved and reviewed for contamination. The Center for Disease Control and Prevention (CDC) criteria were used to classify the blood culture results. The contamination rates were illustrated with a g-chart. Results: We identified 331 false-positive blood cultures, among 32,961 cultured specimens; yielding a contamination rate of 1.0% (95%CI = 0.9% – 1.1%). The highest contamination events occurred in the Emergency department (49.2%), Pediatric ICU (5.2%) and Neonatal ICU (4.8%), respectively. The most common commensal bacterial genus were Staphylococcus coagulase negative (67.1%), Bacillus spp. (10.2%) and Corynebacterium spp. (7.6%), correspondingly. The g-charts could identify 14 abnormal variations, in 41 locations. Conclusion: The contamination rates found were within ranges of other reports. G-charts are simple to construct, easy to interpret and sensitive for detection of real time epidemics

    Antimicrobial Resistance Patterns Amid Community-Acquired Uropathogens in Outpatient Settings of a Tertiary Care Hospital in Thailand

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    Objective: To document the distribution of antimicrobial resistance patterns of community-acquired uropathogens. Materials and Methods: Outpatient microbiology data of urine culture results in Songklanagarind Hospital between January to December 2019 were reviewed. Results: This study included 649 episodes of positive urine cultures in 598 patients, in which 80.7% were symptomatic cases. The elderly (median 63 ± IQR 26 years) showed high prevalence of urinary tract infections in this study, for which nearly 80% of all samples were female. The three most common uropathogens identified were: Escherichia coli (E. coli) (69.6%), Klebsiella pneumoniae (9.5%) and Staphylococcus saprophyticus (4.9%).  E. coli were highly resistant to ciprofloxacin (49.0 %), cotrimoxazole (41.2%) and ceftriaxone (20.6%), but had a low level of resistance to fosfomycin (0%), and amikacin (0.4%). Conclusion: The antimicrobial resistance pattern of E. coli was high for commonly antimicrobial agents used in outpatients; especially quinolone, cotrimoxazole and cephalosporin. However, due to low resistance levels, fosfomycin and amikacin could be considered as effective treatment options for community acquired UTIs in our study

    Going Beyond Counting First Authors in Author Co-citation Analysis

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    The present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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