492 research outputs found
How to use D-dimer in acute cardiovascular care
No full textD-dimer testing is important to aid in the exclusion of venous thromboembolic events (VTEs), including deep venous thrombosis and pulmonary embolism, and it may be used to evaluate suspected aortic dissection. D-dimer is produced upon activation of the coagulation system with the generation and subsequent degradation of cross-linked fibrin by plasmin. Many different assays for D-dimer testing are currently used in routine care. However, these tests are neither standardized nor harmonized. Consequently, only clinically validated assays and assay specific decision limits should be used for routine testing. For the exclusion of pulmonary embolism/deep vein thrombosis, age-adjusted cut-offs are recommend. Clinicians must be aware of the validated use of their hospital's D-dimer assay to avoid inappropriate use of this biomarker in routine care
Som en byracka : självbiografi, estetik och politik i Agneta Klingspors författarskap
No full textThe study deals with Agneta Klingspor’s autobiographical writings from the 1970s until today. Agneta Klingspor made her debut as an author in 1977 with the diary Inte skära bara rispa. Kvinnodagbok 1962–76 (No Cutting Only Scratching. A Woman’s Diary 1962–76). Since then she has written several novels and collections of poetry and short stories. The majority of Klingspor’s texts represent a struggle for the word, both literally and metaphorically. The aim of this study is to investigate that struggle in Agneta Klingspor’s writings on two levels: the autobiographical and the aesthetic.The dissertation is divided into four main parts. Part I reviews relevant research on literary autobiography and takes up a general discussion of referential claims in autobiographical writing, introducing Leigh Gilmore’s theory about the process of authorization, through which autobiographical writings lay claim to the right to speak, and applying it to the genderized process of authorization manifesting itself in Klingspor’s texts. Part I concludes with a sketch of the historical context surrounding Klingspor’s literary debut: the era of women’s politics of the 1970s.Part II deals with the autobiographical themes in Agneta Klingspor’s writings and with their change over time, particularly with the ways in which Klingspor uses, tests and problematizes her autobiographical narration and with how she positions herself in relation to her time and to her own texts in order to achieve authority.Part III describes the struggle for the word in Klingspor’s writings, which occurs both on an aesthetic and on a meta-literary level. The grotesque aesthetics used by Klingspor is analysed as a type of tit for tat: a feminist strategy utilized in order to block a facile understanding of her as a confessor and a woman in the literary field.Part IV juxtaposes the autobiographical and aesthetic levels in a discussion of the political position Klingspor developed in her writings – a stance which is here characterized as the “mongrel’s position”. Klingspor finds many ways of adopting this position. She plays the part of an orphan and outcast in her own life story. She develops an aesthetic attitude associated with the mongrel – she is sniffing out disreputable subject matters linked to body, gender and sexuality. Also, she takes up the position of the mongrel in the literary field, disconnecting herself from the prestigious role of an author and insisting on being a stray dog. The dissertation concludes with an analysis contrasting Klingspor’s representations with the portraits of the mothers in the recent writings of Kerstin Thorvall and Kerstin Bergström – two other well-known authors in the so-called female confessional genre of the 1970s.</p
Inhibition of neutrophil migration in chronic lymphocytic leukaemia : identification and characterization of a new lymphokine
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Tissue factor/FVIIA transactivates the IGF-1R in prostate cancer cells via inhibition of caveolin-1
No full textFormation of the proteolytically active tissue factorFVIIa complex leads to enhanced PDGF-BB-stimulated chemotaxis and IL-8 and TNF-α production in monocytes
No full textPlatelet-derived growth factor-BB and monocyte chemotactic protein-1 induce human peripheral blood monocytes to express tissue factor
No full textMonocytes induced to express tissue factor (TF), the initiator of the clotting cascade, might play an important role in the pathogenesis of atherosclerosis. We have investigated the TF-inducing capacity of two factors thought to be involved in atherogenesis, i.e. the platelet derived growth factor-BB (PDGF-BB) and monocyte chemotactic protein-1 (MCP-1), a member of the chemokine superfamily. PDGF-BB and MCP-1 are potent chemotactic and activating factors for human blood monocytes. alpha-thrombin which is known to induce TF in endothelial cells and that recently has been shown to induce secretion of MCP-1 from endothelial cells and monocytes was also studied. PDGF-BB induced a dose-dependent expression of TF-antigen in monocytes with maximal response at 20-50 ng/mL. At higher concentrations the expression was reduced. No synergistic effect between PDGF-BB and LPS was seen. MCP-1 also induced a dose-dependent TF-expression with maximal response at 50 ng/mL. In contrast to these results thrombin did not. MCP-1 had a slight, but not significant, priming effect on LPS-induced TF expression. These data show that PDGF-BB and MCP-1 are potent inducers of TF in human peripheral blood monocytes. We suggest that this TF-induction might be an important link between hemostasis and inflammation.</p
Tissue factor regulation and cytokine expression in monocyte-endothelial cell co-cultures : effects of a statin, an ACE-inhibitor and a low-molecular-weight heparin
No full textTissue Factor non-coagulant signalling - molecular mechanisms and biological consequences with focus on cell migration and apoptosis
No full textTissue factor (TF), a transmembrane glycoprotein, is the main initiator of the blood coagulation cascade. TF is also recognized as a true signalling receptor. There is accumulating evidence that the downstream signalling events by the TF-complexes are transduced by several mechanisms including; activation of the protease activated receptors (PAR)-1 and -2 and the PARs-dependent pathways, via the TF cytoplasmic domain and by transactivation of receptor tyrosine kinases. Triggering of signalling cascades such as the mitogen-activated protein kinase (MAPK) and PI3kinase/AKT pathways couples TF to a multitude of functions within the cell, such as proliferation, cell migration and survival. Thus, TF has a Janus face; on the one side vital life upholding functions and on the other harmful effects, exemplified in inflammation, the acute coronary syndromes and cancer. TF mediates a broad spectrum of signalling mechanisms. Learning more about these different mechanisms/pathways will lead to new treatment strategies, ultimately personalized.</p
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