1,721,104 research outputs found
Questions and answers on antithrombotic therapy and revascularization strategies in non-ST-elevation acute coronary syndrome (NSTE-ACS): a companion document of the 2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation
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Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Genetic Determinantes of Clopidogrel Response - Analyses of CYP2C19*2 and CYP2C19*17
No full textNach einer Koronarintervention erhalten Patienten eine duale antithrombozytäre Therapie mit ASS und Clopidogrel um das peri- und postinterventionelle Risiko thrombotischer Komplikationen zu reduzieren. Für Clopidogrel ist das individuelle Ansprechen auf die Behandlung jedoch nicht einheitlich. Vor allem das polymorph exprimierte Leberenzym CYP2C19 hat einen Einfluss auf die in vivo Wirkung von Clopidogrel. Ziel dieser Arbeit war es den isolierten und wechselseitigen Einfluss von zwei häufigen CYP-Allelen (CYP2C19*2 und CYP2C19*17) auf die Metabolisierung und damit auf die Aktivierung von Clopidogrel zu untersuchen und einen Zusammenhang mit ischämischen Ereignissen (*2) oder Blutungskomplikationen (*17) aufzuzeigen. Zusätzlich wurde die Wechselwirkung von Clopidogrel mit Omeprazol auf die Werte der ADP-induzierten Thrombozytenaggregation untersucht. Neben der Genotypisierung auf die zwei untersuchten Allele erfolgten Messungen der ADP-induzierten Thrombozytenaggregation mittels Multiplate Analyzer. Abhängig vom jeweiligen Genotypen und der hierdurch veränderten Metabolisierung von Clopidogrel zeigte sich ein gesteigertes Blutungsrisiko bei Patienten mit *17-Trägerstatus bzw. ein erhöhtes Risiko für ischämische Komplikationen wie Stentthrombosen für Patienten mit der *2-Allelvariante. Hinsichtlich des Einflusses von Omeprazol zeigte sich eine allelunabhängige, hemmende Wirkung auf den Clopidogrelmetabolismus.After coronary interventions patients get treated with a dual antiplatelet therapy with ASS and Clopidogrel to reduce the peri- and postinterventional risk for thrombotic complications. It is known that there is an individual, non uniform response to treatment with Clopidogrel. Especially the polymorphically expressed liver enzyme CYP2C19 has influence on the Clopidogrel metabolism and therefore its effects in patients. Aim of these two studies has been to inquire the isolated and mutual influence of the two most common CYP-alleles (CYP2C19*2 and CYP2C19*17) on the Clopidogrel metabolism by examinating the activation of Clopidogrel depending on the genotype and thereby to show a connection to ischemic events (*2) or bleedings (*17). Furthermore the interaction of Clopidogrel and Omeprazol regarding its effect on the ADP-induced platelet aggregation has been object of these studies. The alleles were identified by genotyping, platelet function was tested with the Multiplate Analyzer. Depending on the genotype and the hereby changed metabolism there is a higher risk for bleeding in patients carrying the *17-allel respectively an increased risk for ischemic events like stent thrombosis for *2-carriers. Concerning the influence of an interactive effect of Clopidogrel and Omeprazol, it was possible to show an independently inhibitory effect on the Clopidogrel metabolism
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Pharmacogenetic and pharmacodynamic analyses of the clopidogrel-effect in patients receiving coronary stents
No full textUnter 2485 Stent-Patienten unter dualer Thrombozyten-Aggregationshemmung mit Aspirin und Clopidogrel erlitten CYP2C19*2-Träger signifikant häufiger Stent-Thrombosen, ST-Hebungsinfarkte und ischämische zerebrale Insulte als Wildtyp-Homozygote. An 69 Stent-Patienten zeigte sich über 8 Wochen durch wiederholte Thrombozyten-Aggregationsmessungen mittels Lichttransmissions-Aggregometrie und Multiple Electrode Aggregometrie kein Vorteil eines ausschleichenden versus abrupten Absetzens von Clopidogrel.In 2485 patients receiving coronary stents under dual antiplatelet therapy with aspirin and clopidogrel carriers of the CYP2C19*2 allele suffered significantly more frequently under stent thrombosis, STEMI and ischaemic stroke than wildtype-homozygotes. In 69 Stent-Patients weekly platelet function tests over 8 weeks with light-transmission aggregometry and multiple electrode aggregometry showed no benefit of a tapering versus an abrupt cessation of clopidogrel treatment
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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