1,723,656 research outputs found
Replication Data for: 'The Anatomy of a Hospital System Merger: The Patient Did Not Respond Well to Treatment'
No full textThese files replicate the figures and tables in "The Anatomy of a Hospital System Merger: The Patient Did Not Respond Well to Treatment" by Martin Gaynor, Adam Sacarny, Raffaella Sadun, Chad Syverson and Shruthi Venkatesh. Please see the readme.txt for more information
Real-time processing and visualization of intensive care unit data
No full textThesis: M. Eng., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2017.This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.Cataloged from student-submitted PDF version of thesis.Includes bibliographical references (page 83).Intensive care unit (ICU) patients undergo detailed monitoring so that copious information regarding their condition is available to support clinical decision-making. Full utilization of the data depends heavily on its quantity, quality and manner of presentation to the physician at the bedside of a patient. In this thesis, we implemented a visualization system to aid ICU clinicians in collecting, processing, and displaying available ICU data. Our goals for the system are: to be able to receive large quantities of patient data from various sources, to compute complex functions over the data that are able to quantify an ICU patient's condition, to plot the data using a clean and interactive interface, and to be capable of live plot updates upon receiving new data. We made significant headway toward our goals, and we succeeded in creating a highly adaptable visualization system that future developers and users will be able to customize.by Shruthi Narayanan.M. Eng
Sleep and cardiac dysfunction in Kv1.1 KO mice, a model of Sudden Unexpected Death in Epilepsy (SUDEP)
No full text[No Abstract, using the opening paragraph]|Epilepsy is a chronic, broad spectrum neurological disease which is characterized by recurrent and unprovoked seizures (Fisher et al. 2014). It is the fourth most common neurological disease affecting approximately 50 million people globally (Leonardi and Ustun 2002). In fact, it is estimated that about 1 in 26 people in the United States, will develop epilepsy during some point in their lifetime (Hesdorffer et al. 2011). The pathophysiology of epilepsy and seizures involves a chronic hyper excitability of the brain caused by hyperactive and hyper synchronous neuronal firing. This increase in neuronal excitability in epilepsy may be caused by a varied range of factors, channelopathies, and alterations in synaptic transmission, changes in levels of neurosteroids or neuropeptides or metabolic disorders. These abnormal changes may be the resultant of genetic abnormalities and developmental disorders, brain injury or trauma, stress or may be idiopathic in nature (Berg and Scheffer 2011; Shorvon 2011).ProQuest Traditional Publishing Optionviii, 86 page
Investigating Central Chemoreception-based Biomarkers of Sudden Unexpected Death in Epilepsy (SUDEP)
No full text2025Sudden Unexpected Death in Epilepsy (SUDEP) causes significant mortality in epilepsy, affecting 1:1000 people every year. Preceding SUDEP, patients experienced a final GTC seizure, transient apneas and bradycardia, culminating in terminal apnea and asystole. Failure to recover from postictal hypercapnia and hypoxia (HH) is a critical risk factor for SUDEP. Central chemoreception initiates adaptive cardio-respiratory and autoresuscitation responses to HH changes, and is impaired in epilepsy and SUDEP. We have reported that the Kcna1-/- (KO) model of SUDEP, have increased GTCs, apnea, and chronic intermittent hypoxia (CIH) preceding SUDEP. We hypothesize that KO mice have impaired central chemoreception and autoresuscitation failure that contributes to their SUDEP susceptibility. We assessed the role of orexin antagonism and CIH in mitigating chemoreception dysfunction in preclinical SUDEP. Using non-invasive cardiorespiratory monitoring, we found that KO mice experienced increased apneas, intermittent bradycardia and hypoxia as they approached SUDEP. Using whole-body plethysmography, we found that high-risk KO mice had elevated ventilatory chemoresponses to a mild HH challenge (mimicking transient apnea) while 71% of KO mice failed to survive a severe HH challenge (mimicking terminal apnea). We next determined whether chemosensing orexin was involved in these responses. Orexin neurons exhibited exaggerated ex vivo chemosensitivity to low pH and may be upstream of the altered HH chemoresponses. Blocking orexin receptors improved cardio-respiration, oxygen saturation, and longevity of KO mice. It also rescued their in vivo ventilatory chemoresponses during mild and severe HH challenge and enabled survival. In response to a novel anoxia-autoresuscitation test (97% N₂, 3% CO₂), a majority of KO mice (~80%) had altered ventilatory chemoresponses and gasping parameters and succumbed to autoresuscitation failure and death. The risk of autoresuscitation failure increased with higher SUDEP risk. CIH pretreatment rescued ventilatory chemoresponses, improved gasping and enabled a majority of high-risk KO mice to autoresuscitate successfully and survive. Overall, these findings provide strong evidence that central chemoreception dysfunction contributes to autoresuscitation failure and death in a preclinical SUDEP model. We identified novel chemoreception-based cardiorespiratory biomarkers that may serve as predictors of SUDEP risk. This work highlights orexinergic pathway and CIH as promising targets for future SUDEP prevention studies
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
- …
