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Management of Shiva optics
No full textIn the design and procurement of a high power laser system such as the Shiva Fusion Laser at LLNL, the optical components are the single most important aspect for optimum laser performance. The cost, schedule and quality of the optics are the driving parameters for the entire program and many factors are involved in controlling, monitoring and evaluating these parameters. These factors include (1) the procurement cycle, (2) knowledge of the vendors, (3) realistic specifications, (4) understanding of the fabrication process, (5) the quality control and test requirements. Guidelines and examples of the methods used in the procurement and qualification of the optics in Shiva will be presented
Altered PPARα-dependent transcription in SHIVA mice.
No full text<p>GSEA comparing fasting SHIVA versus PPARα<sup>−/−</sup> mice (n = 3–4 mice) (A) Heat map displaying the relative expression levels ranked from high (red) to low (blue) the most enriched genes (complete results are in Table S2 in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0104925#pone.0104925.s001" target="_blank">File S1</a>). Gene set enrichment plot showing skewing to the left, indicating enrichment in WT versus SHIVA livers of genes found down-regulated in PPARα-deficient mouse livers. Enrichment Score (ES): 0.5358231, Normalized Enrichment Score (NES): 2.257458, Nominal p-value: 0.0, FDR q-value: 0.04381425. (B) Quantification by qRT-PCR of various transcripts in livers from fed (black symbols) or 24 hours fasted (open symbols), WT versus SHIVA mice (n = 3 to 4 mice per condition). These mice are distinct from that used in the microarray analysis. (C) Similar analysis showing the relative expression evaluated by qRT-PCR performed on liver mRNA from 48 h fenofibrate-treated WT or SHIVA (SHI) mice for a series of PPARα target transcripts. (D) qRT-PCR analysis of <i>ppara</i> and <i>sox17</i> transcripts in fed or 48 hours fasted mice.</p
ShIVA source code
No full textSingle-cell technologies have revolutionised biological research and applications. As they continue to evolve with multi-omics and spatial resolution, analysing single-cell datasets is becoming increasingly complex. For biologists lacking expert data analysis resources, the problem is even more crucial, even for the simplest single-cell transcriptomics datasets.
We propose ShIVA, an interface for the analysis of single-cell RNA-seq and CITE-seq data specifically dedicated to biologists. Intuitive, iterative and documented by video tutorials, ShIVA allows biologists to follow a robust and reproducible analysis process, mostly based on the Seurat v4 R package, to fully explore and quantify their dataset, to produce useful figures and tables and to export their work to allow more complex analyses performed by experts. </p
Pathway analysis of liver transcriptome in SHIVA mouse.
No full text<p>Pathway analysis of liver transcriptome in SHIVA mouse.</p
Sundarar, the Companion Disciple, and Lord Shiva
No full textSundarar also has the names Vanthondar (Firm disciple) and Thambiran Thozhan. He was the one who sang about Thiruthontar who was responsible for the creation of Periyapuranam. Thambiran was also known as a companion. Friendly actions form the article. Alala Sundarar was doing service to Lord Shiva at Thirukkayilai. He used to go to the garden every day, pluck flowers and offer it to the Lord. He performed the ritual of offering garlands to the Lord and standing with Sacred Ash. One day when he went to the garden, the two friends of Goddess Parvati, Aninthithai and Kamilini, came there. Sundarar was in love with both of them and enjoyed themselves. Therefore, there was a delay in taking the flower and going to the Shiva Shrine. Realizing this, Lord Shiva told them that to cherish the fullest of love they should go to earth and be born in Tamil Nadu. And from they can continue serving the Lord. Thus, the three came and were born in this world with the names Sundarar, Paravai Nachiyar, and Sangili Nachiyar
shivareddyiirs/QRealTimePlugin: ISPRS Summer School Release
No full text<p>This plugin version is released and used in ISPRS Summer School on "Geoprocessing Tools and Technology in Citizen Science" conducted at Indian Insitute of Remote Sensing, ISRO, Dehradun during Oct 30-Nov 3, 2017</p>
Sox17 mutation and transcriptional defect in the SHIVA mouse.
No full text<p>Comparative analysis of Vnn1 expression in WT versus SHIVA mice using (A) Pantetheinase activity (pPNa substrate) and Vnn1 ELISA in serum (n = 13 to 16 mice); (B) qRT-PCR analysis of <i>vnn1</i> transcripts in liver and kidney (n = 4–5 mice); (C) Localization of the mutation in the HMG domain of the Sox17 protein. (D) Quantification by qRT-PCR of <i>Fgb</i> transcripts in liver from WT or SHIVA mice (*: p<0.05, **: p<0.005, ***: p<0.0005). (E) Luciferase reporter assays performed 48 hrs following cotransfection of the coding (Sox17, Sox9) and reporter (pH 4×4, pVCAM1, pVnn1) plasmids in COS7 or AML12 cells.</p
Shiva Myth A Study of Amish Tripathi’s The Immortals of Meluha.pdf
No full textShiva is one among the supreme deities of Hindu mythology. He has been subject of all the literary works from traditional knowledge to gift text. The Immortals of Meluha, the primary novel in Shiva trio by Amish Tripathi is additionally heavily embedded in Indian mythology. The narrative of The Immortals of Meluha builds on the Shiva story that is central to the narrative structure nevertheless it holds a mirror to this social reality. The difficulty of setting pollution is self-addressed within the novel. The plot is ready in 1900 B.C. however the things that he portrays are the duplicate of this. The story is employed as a trope for modern society. The new writers with their trendy sensibility recast ancient tales or narratives from their new perspective to replicate on and touch upon modern reality. This study traces the Shiva story in Amish‟s novel „The Immortals of Meluha
Experimental studies on biotite- and muscovite-granites and some crustal magmatic sources
No full textHigh-grade metamorphism is certainly associated with melting and the
formation of migmatites, and migmatization may culminate in the
production of discrete bodies of granite. I am impressed, however, by the
evidence that most granitic intrusions represent a single, frozen stage in a
complex sequence of events with origin in the mantle, rather than in the
crust. Recent trace element and isotope studies of many granites confirm
that these were derived from source materials in both mantle and crust
(Atherton and Tarney, 1979). Heat and magmas from the mantle
generate more magma by partial fusion of crustal rocks. The magmas
rise through the crust, in ways controlled by the regional tectonics. They
may become stalled to form batholiths, they may blister upwards into
plutonic stocks, and they may burst through to the surface in volcanic
eruptions. They exsolve hot, enriched, aqueous solutions during the late
stages of solidification, and they impel meteoric water into enormous
subterranean circulation s. The solutions cause chemical changes in both
intrusive and country rocks
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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