1,720,954 research outputs found
Nanodrug Combined with Physical Methods for Cancer Tumor Treatment in A Mouse Ear Model
No full text近年來有研究指出，藥物搭配超音波與微氣泡和藥物搭配熱治療兩者治療腫瘤的方式皆能強化藥物傳遞，進而增加藥物在腫瘤內的濃度，使腫瘤得到較好的治療效果。而本研究利用小鼠耳朵腫瘤模型(Mouse Ear Tumor Model)，使用奈米藥物Doxil、超音波與微氣泡及43℃加熱15分鐘之熱治療三種治療方式互相做搭配，探討在治療腫瘤的情形，總共治療八次，每兩天治療一次，治療前四次後，休息一個星期之後，再持續給予後四次的治療。研究結果觀察到真正對腫瘤治療比較有效的是奈米藥物Doxil搭配上超音波及微氣泡、奈米藥物Doxil搭配上43℃加熱15分鐘之熱治療、奈米藥物Doxil搭配上超音波及微氣泡又加再加上43℃加熱15分鐘之熱治療這三組；而以腫瘤生長狀態而言，又以奈米藥物Doxil搭配上超音波及微氣泡再加上43℃加熱15分鐘之熱治療和奈米藥物Doxil搭配上43℃加熱15分鐘之熱治療這兩組較有效，而奈米藥物Doxil搭配上超音波及微氣泡再加上43℃加熱15分鐘之熱治療甚至能使腫瘤逐漸變小到幾乎看不見，在小腫瘤的治療上有相當顯著的治療效果。Studies show that ultrasound (US) with microbubbles (MB) or hyperthermia (HT) could enhance the delivery of nanoparticles into tumor tissues. In this research, we used mouse ear tumor model to study the effectiveness of nanodrug on the tumor treatment with the enhancement of ultrasound/ microbubbles and/or hyperthermia, and observed the tumor growth with microscopy. The treatment procedure was arranged with four successive treatments every other day, and then followed the same four successive treatments after a week off.Experimental results showed that treatment enhancement can be observed for nanodrug injection followed by MB/US, or HT (43℃, 15 min),or MB/US/HT. The treatment set with MB/US/HT following nanodrug injection can even make the tumor disappear. The results of this study indicates that MB/US/HT following the injection of nanodrug is a very promising method for effective tumor treatment
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
A Study on Disappearance or Dawn Reappearance of Financially Distressed Firms
No full text[[abstract]]本研究以存活分析(Survival Analysis)中的 Cox 迴歸模型，研究影響公司 陷於財務危機中之因素，是否同樣影響後續破產下市存活機率和敗部復活恢 復機率。研究結果顯示，平均來說有關流動性、獲利能力、資本結構與公司 治理等變數，在 3 個 Model 中皆有顯著差異。Model 1，當速動資產愈多、 獨立董事比率與內部股東持股愈小者，財務危機發生之可能性愈大。在 Model 2，高舉債和過多的獨立董事比率將提高破產下市機率，而無論是破產下市 或敗部復活 Model，外部股東持股比率愈高、控制權對現金流量權比率愈大， 可降低破產下市之機率，但也減低了敗部復活之機會。而不同產業以及是否 為家族企業，兩者皆不影響破產機率與恢復機率。結果顯示導致當初影響財 務危機發生的因素，不再是使其破產下市或敗部復活之原因。 另外發現，財務危機發生日到破產下市日的存活期間約 18 個月，而財 務危機發生到敗部復活的恢復期間約為 23 個月，表示敗部復活所需恢復時 間要比破產下市存活時間來的長，且當觀察時間越長，將使得破產下市和敗 部復活的存活機率減少。[[abstract]]We have three Model and quote the Cox regression from survival analysis to research whether the factor causes financial distress also affects recovery and bankruptcy or not. The result that current variable, profitability variable, capital structure variable and corporate government variable have difference influence at three stages. At the first model, High quick asset, low independent directors and inside ownership will increase finance distressed probability. High debt ratio and unnecessary independent directors will increase bankruptcy probability. At the second and third model, high outside ownership and control-to-cash flow right ratio not only decrease bankruptcy probability but also decrease recovery probability. In sum, finance distressed factors will not influence bankruptcy or recovery. In average, the second stage survival time is eighteen months and the third stage recovery time is twenty-three months. It shows that recovery will spend more time to recover than bankruptc
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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