1,721,372 research outputs found
Outside Directors and R&D investment: An Experience after the Corporate Governance Reform in Korea
No full textShin Yoo
No full textSpectra-Based Fault Localisation (SBFL) aims to assist de- bugging by applying risk evaluation formulæ (sometimes called suspiciousness metrics) to program spectra and ranking statements according to the predicted risk. Designing a risk evaluation formula is often an intuitive process done by human software engineer. This paper presents a Genetic Programming approach for evolving risk assessment formulæ. The empirical evaluation using 92 faults from four Unix utilities produces promising results 1 Genetic Programming (GP) may dramatically increase the performance of software written by domain experts. GP and autotuning are used to optimise and refactor legacy GPGPU C code for modern parallel graphics hardware and software. Speed ups of more than six times on recent nVidia GPU cards are reported compared to the original kernel on the same hardware.. GP-evolved equations can consistently outperform many of the human-designed formulæ, such as Tarantula, Ochiai, Jaccard, Ample, and Wong1/2, up to 5.9 times. More importantly, they can perform equally as well as Op2, which was recently proved to be optimal against If-Then-Else-2 (ITE2) structure, or even outperform it against other program structures.
Engineering Escherichia coli for increased productivity of serine-rich proteins based on proteome profiling
No full textVariations in proteome profiles of Escherichia coli in response to the overproduction of human leptin, a serine-rich (11.6% of total amino acids) protein, were examined by two-dimensional gel electrophoresis. The levels of heat shock proteins increased, while those of protein elongation factors, 30S ribosomal protein, and some enzymes involved in amino acid biosynthesis decreased, after leptin overproduction. Most notably, the levels of enzymes involved in the biosynthesis of serine family amino acids significantly decreased. Based on this information, we designed a strategy to enhance the leptin productivity by manipulating the cysK gene, encoding cysteine synthase A. By coexpression of the cysK gene, we were able to increase the cell growth rate by approximately twofold. Also, the specific leptin productivity could be increased by fourfold. In addition, we found that cysK coexpression can improve the production of another serine-rich protein, interleukin-12 beta chain, suggesting that this strategy may be useful for the production of other serine-rich proteins as well. The approach taken in this study should be useful in designing a strategy for improving recombinant protein production.This work was supported by the National Research Laboratory Program
(grant 2000-N-NL-01-C-237) of the Ministry of Science and
Technology; the Basic Industrial Research Project of the Ministry of
Commerce, Industry and Energy; and the Brain Korea 21 project.
Hardware for the analysis of proteomes was supported by the IBMSUR
program
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Clustering Test Cases to Achieve Effective and Scalable Prioritisation Incorporating Expert Knowledge
No full textPair-wise comparison has been successfully utilised in order to prioritise test cases by exploiting the rich, valuable and unique knowledge of the tester. However, the prohibitively large cost of the pairwise comparison method prevents it from being applied to large test suites. In this paper, we introduce a cluster-based test case prioritisation technique. By clustering test cases, based on their dynamic runtime behaviour, we can reduce the required number of pair-wise comparisons significantly. The approach is evaluated on seven test suites ranging in size from 154 to 1,061 test cases. We present an empirical study that shows that the resulting prioritisation is more eective than existing coverage-based prioritisation techniques in terms of rate of fault detection. Perhaps surprisingly, the paper also demonstrates that clustering (even without human input) can outperform unclustered coverage-based technologies, and discusses an automated process that can be used to determine whether the application of the proposed approach would yield improvement
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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