8,708 research outputs found
ROSENTHAL, Eric Inventory of documents
No full textCOVERAGE 1904; 1 File; 011 metre.Private papers of Eric Rosenthal, author, journalist and broadcaster
tritrophic-dispersal-model: Code used for creating figures for "Non-hierarchical dispersal promotes stability and resilience in a tri-trophic metacommunity"
No full text<p>This is the commented code used for creating figures for the paper. Any questions regarding the code should be directed to the corresponding author and repository owner (Eric Pedersen). </p>
Eric Velazquez Spanish Language Picture Book Award 2022 Acceptance Speech
No full textAuthor Eric Velazquez gives his Silver Medal acceptance speech for Pulpo Guisado (Holiday House)https://educate.bankstreet.edu/spanishlanguageaward/1001/thumbnail.jp
Eric C. Lincoln, Professor of Sociology and Religion, 1971
No full textThis is an interview with Eric C. Lincoln. Eric was a Professor of Sociology and religion, Union Theological Seminary and author of many books and articles on Negro history. In this recording the contributors discuss local memphis politics, sociology, and race relations compared to that of other cities in the South and the rest of the country
Interview with Eric Bentley, author, drama critic, and playwright
No full textDistinguished drama critic and Bertolt Brecht scholar, Eric Bentley is interviewed by WTMJ-TV host Jim Peck and John B. Fuegi, associate professor of Comparative Literature. Bentley recalls his association with Brecht, the critical and creative aspects of literature, and his interest in writing plays for the theater.GrayscaleSoun
Abstract 4168: Altering cisplatin sensitivity by manipulating the cellular metallome
No full textAbstract
The cellular metallome serves as an important reservoir to meet the biological needs of the cell, serving as enzyme co-factors and ensuring proper protein folding. Recent studies have suggested that cancer cells adapt their metallome in order to accommodate rapid cellular growth and metabolism pathways. Thus, altering the cancer metallome may yield new avenues to target cancer and change the responsiveness to chemotherapy. Here, we aim to characterize and understand how changes in the ovarian cancer metallome affect sensitivity to the chemotherapy drug cisplatin. Five ovarian cancer cell lines were used in experiments: A2780, A2780/CP70, SKOV3, OVCAR3, and CAOV3. The metallome was manipulated by treating cells with either zinc, copper, magnesium, calcium, iron, manganese, or the metal chelator tetrathiomolybdate. Cisplatin sensitivity after metal treatment was measured by WST-1 cell proliferation assays. Metallomes were quantitated by Inductively Coupled Plasma-Mass Spectrometry (ICP-MS) by measuring the following metals: zinc, copper, magnesium, calcium, molybdenum, manganese, iron, phosphorous, and sulfur. Cellular metal concentrations were normalized to sulfur levels. Changes in cisplatin sensitivity were evaluated by measuring cellular cisplatin uptake by ICP-MS. Treatment of ovarian cancer cells with various metals resulted in differences in cellular proliferation and metallome composition. The changes in the metallome were not singular in nature because altering one metal resulted in changes in multiple metals. Cisplatin sensitivity was additionally affected under different metal treatments. Preliminary data suggest that cisplatin uptake was altered as a mechanism to mediate the cellular response to cisplatin, however other mechanisms such as DNA repair might also play a role. In conclusion, we demonstrate that perturbations of the cancer metallome result in changes of various metals, cellular proliferation, and sensitivity to the chemotherapy drug cisplatin. The data lend further insight into how an individual’s metallomic status, a combination of nutritional and harmful metal exposure, might result in the development and progression of cancer and affect the response to chemotherapy.
Citation Format: Lauren Amable, Eric Shide. Altering cisplatin sensitivity by manipulating the cellular metallome [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 4168. doi:10.1158/1538-7445.AM2017-4168</jats:p
Dr. Eric Yellin – Faculty Author Interview
No full textDr. Eric Yellin, Associate Professor of History and American Studies discusses his new book, Racism in the Nation’s Service: Government Workers and the Color Line in Woodrow Wilson’s America, published recently by the University of North Carolina Press. In this book, Dr. Yellin argues that President Wilson’s administration successfully segregated the federal government in the age of progressive politics. He investigates how the enactment of the segregation policy imposed a color line on American opportunity and implicated Washington in the economic limitation of African Americans for decades to com
Essentials of Dental Radiography and Radiology / Eric Whaites and Nicholas Drage.
No full textPrevious edition: Essentials of dental radiography and radiology / Eric Whaites. Fourth edition. Edinburgh ; New York : Churchill Livingstone, 2007.Includes bibliographical references (pages 461-464) and index.x, 478, [2] pages
10th C. Eric Lincoln Lecture Series, 1992
No full textPart of the 10th anniversary of the C. Eric Lincoln lecture series Dr. Love Henry Whelchel moderates a panel of scholars. The panel includes Dr. C. Eric Lincoln, Dr. Jacquelyn Grant, and Dr. John Hope Franklin. The panel discusses the life of George Washington Williams (author of History of the Negro Race in America). The discussion includes issues related to Womanist theology, Islamic religion, sociology, religion and history.The Atlanta University Center Robert W. Woodruff Library acknowledges the generous support of the National Endowment for Humanities - Humanities Collections and Reference Resources Implementation Project Grant in supporting the processing and digitization of a number of its major archival collections as part of the project: Spreading the Word: Expanding Access to African American Religious Archival Collections at the Atlanta University Center Robert W. Woodruff Library
Abstract 1496: Connecting the metallome with metabolism in ovarian cancer
No full textAbstract
Ovarian cancer has historically been diagnosed late stage and lacks effective biomarkers for detection and prognosis. The deregulation of metabolism and signaling cascades inherent of cancer may contribute to aberrant levels of metal within cells. Biological processes essential for cell proliferation require metals for enzyme cofactors, signaling molecules, and structural components. Metallomics is the study of the comprehensive, dynamic metal profile within cells. The goal of our study was to characterize the ovarian cancer metallome at the level of whole cell and mitochondria in comparison to non-cancer. Additionally, cellular metabolism was analyzed to connect the mitochondrial (mito-)metallome to mitochondrial function. Ten human ovarian cancer cell lines were used for experiments: A2780, CAOV3, A2780/CIS, A2780/CP70, ES2, OVCAR3, OVCAR5, SKOV3, TOV112, and TOV21. Three non-cancer human ovarian cell lines of epithelial and fibroblast origin served as controls. Inductively coupled mass spectrometry (ICP-MS) was used to evaluate the metallome by measuring the following metals: calcium (Ca), copper (Cu), iron (Fe), magnesium (Mg), manganese (Mn), molybdenum (Mo), phosphorous (P), sulfur (S), selenium (Se), and zinc (Zn). An XF24 Seahorse analyzer was used to measure cellular metabolism and mitochondrial function in the ovarian cancer and non-cancer cell lines. Our results demonstrated that there was a distinct metal profile at the level of the whole cell and mitochondria in ovarian cancer cells compared to non-cancer ovarian cells. The whole cell ovarian cancer metallome consisted of increased Mg, P, and Cu, and decreased Fe, Mn, and Se in comparison to non-cancer. The cancer mito-metallome consisted of increased Mg, P, Cu, Zn, Se, and Ca. Referencing established literature of the known metals that serve as cofactors for mitochondrial proteins, the relationship between the mito-metallome and functional metabolic pathways was established. Changes in cellular metabolism were reflected by changes in the mito-metallome. Our study was the first to evaluate an extensive panel of metals simultaneously in the mitochondria and bridge the unique metal signature of ovarian cancer to cell metabolism. Future proteomics studies will be used to further validate the connection of metals to cellular function. Metallomics and the ovarian cancer cell metallome provide further understanding of how cancer deregulates the metallome and how metallomics may provide an avenue for identifying new cancer biomarkers and allow for effective targeting of cancer with chemotherapy.
Citation Format: Eric D. Shide, Lauren Amable. Connecting the metallome with metabolism in ovarian cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 1496. doi:10.1158/1538-7445.AM2017-1496</jats:p
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