96 research outputs found
Devices, techniques, traction, suturing, and countermeasures for endoscopic submucosal dissection complications
No full textEndoscopic submucosal dissection (ESD) is widely performed to treat superficial colorectal tumors because it enables en bloc resection of various types of lesions. However, ESD sometimes leads to deleterious adverse events, such as perforation and delayed bleeding. Therefore, determining the precise preoperative indication for ESD is vitally important. Furthermore, small lesions with fibrosis and semi-large lesions can be managed using underwater endoscopic mucosal resection, and the “true” indication for ESD is for the treatment of larger lesions, for which ESD carries a higher risk. Here, we reviewed the devices, techniques (i.e., pocket creation method, water pressure method, and clip and flap method), traction (i.e., clip with line, pulley method, and clip with ring), suturing (i.e., line-assisted complete closure, loop clip, clip-on-clip closure method, mucosal incision around the mucosal defect, and hand-suturing), and countermeasures to address complications (i.e., bleeding after ESD, perforation, and post-ESD coagulation syndrome) that facilitate easier and safer ESD
Report of the international symposiums at the 93rd Congress of Japan Gastroenterological Endoscopy Society in Osaka, 2017
No full textCase of colonic adenoma involving a diverticulum resected by a traction‐assisted endoscopic submucosal dissection technique
No full textSemi‐circumferential endoscopic submucosal dissection for laterally spreading tumors on the ileo‐ascending colon anastomosis
No full text内視鏡的胃炎および組織学的胃炎による胃癌リスク分類
No full text学位の種別: 課程博士審査委員会委員 : (主査)東京大学教授 森屋 恭爾, 東京大学教授 瀬戸 泰之, 東京大学准教授 藤城 光弘, 東京大学准教授 池上 恒雄, 東京大学講師 伊地知 秀明University of Tokyo(東京大学
Endoscopic naso‐biliary and ‐pancreatic duct drainage for refractory post‐bulbar duodenal ulcer bleeding
No full textEffects of carriers on transgene expression from plasmids containing a DNA sequence with high histone affinity
No full textThe intranuclear disposition of plasmid DNA is highly important for transgene expression. The effects of a left-handedly curved sequence with high histone affinity on transgene expression were examined in COS-7 cells with two kinds of carriers (Lipofectamine Plus and TransIT-LT1). Three plasmids containing the curved sequence at different positions were transfected. The transgene expression was affected by the position of the left-handedly curved sequence, and the sequence at appropriate locations enhanced the expression from plasmid DNAs. However, the position effects on the expression differed from those obtained by electroporation of the same plasmid DNAs in a naked form. In addition, the degree of expression enhancement seemed to depend on the carriers. These results suggest that the left-handedly curved sequence with high histone affinity could increase the transgene expression from a plasmid delivered with carriers
Boundary integral equation approach based on a polynomial expansion of the current distribution to reconstruct the current density profile in tokamak plasmas
No full textA new approach has been proposed to reconstruct the current density profile in tokamak plasmas. The boundary-only integral equation derived from the Grad–Shafranov equation, under the assumption of polynomial expansion of current density, will have no unknowns except for the polynomial expansion coefficients, once the magnetic flux and its derivative have been given along the plasma boundary with the aid of Kurihara's Cauchy-condition surface method based on magnetic sensor data. In addition to the discretized form of the equation, some constraints are taken into account: the total plasma current, zero-current along the plasma boundary and a scalar relationship derived from the MHD equilibrium to relate the current density to the magnetic flux. It is also assumed that the poloidal field, as a quantity closely related to the current density, can be measured at a certain number of points inside the plasma. The whole set of linear equations is solved using the singular value decomposition technique to determine the polynomial expansion coefficients. The validity of the present technique and the quality of the current density solution have been investigated through test calculations for some plasma configurations
Efficacy of triple therapy with esomeprazole, amoxicillin, and sitafloxacin as a third-line Helicobacter pylori eradication regimen
No full textSummaryObjectiveTo examine the efficacy of third-line Helicobacter pylori eradication therapy with esomeprazole, amoxicillin, and sitafloxacin for patients with clarithromycin- and metronidazole-based first- and second-line therapy failure.MethodsThirty patients with first- and second-line H. pylori eradication failure were treated prospectively with esomeprazole 20mg twice daily, amoxicillin 750mg twice daily, and sitafloxacin 100mg twice daily for 7 days. After 8–12 weeks, the outcome of eradication therapy was assessed by 13C-urea breath test or stool antigen test.ResultsAll 30 patients completed the study. Eradication was successful in 25 patients and the eradication rate was 83% in the intention-to-treat and per-protocol analyses. No specific or significant adverse events were recorded in the 30 patients. Patient characteristics such as sex, body mass index, and pepsinogen I/II ratio did not differ between patients who were treated successfully and those who were not treated successfully.ConclusionsThird-line H. pylori eradication therapy with esomeprazole, amoxicillin, and sitafloxacin is as safe and effective as previously reported sitafloxacin-based triple therapy
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