180,822 research outputs found
sj-png-1-nah-10.1177_02601060221139628 - Supplemental material for Unwinding the potentials of vitamin C in COVID-19 and other diseases: An updated review
No full textSupplemental material, sj-png-1-nah-10.1177_02601060221139628 for Unwinding the potentials of vitamin C in COVID-19 and other diseases: An updated review by Nikhil Mehta, Purvi Pokharna and Saritha R Shetty in Nutrition and Health</p
Modern Approaches in IOT and Machine Learning for Cyber Security
No full textDr. Vijay Anand. R, Dr. Jayalakshmi. P, Dr. Spoorthi Pushparaj Shetty, Dr. Mohammed Shahbaz Kha
Problems in computer security
No full textAuerbach, R.L.; Kerbel, N.; Megraw, M.; Osburn, R.; Shetty, S.; Hoffman, J.. (1998). Problems in computer security. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/3251
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Local Inflammatory Responses in Pseudomyxoma Peritonei
No full textPseudomyxoma peritonei (PMP) is a peritoneal neoplastic disease arising from MUC2 producing goblet cells of the appendix and is characterized by the accumulation of massive amounts of mucinous ascites. Little is known about the tumor microenvironment that might give insight into the local inflammatory processes in the peritoneal cavity. The aim of this study was to characterize this tumor microenvironment in terms of cytokine expression, to determine their cellular source and biological effect on cell growth.|Multiplex cytokine assays were conducted on 37 ascites and 13 serum specimens from PMP patients to determine the cytokines expressed with a focus on pro-inflammatory cytokines. Tissue sections from 10 PMP specimens were immunostained for interleukin 6 (IL-6), interleukin 8 (IL-8), interferon inducible protein 10 (IP-10) and monocyte chemotactic protein 1 (MCP-1). Effects of IL-6 and IL-8 on cell growth were determined using recombinant human cytokines and the human mucinous colorectal cell line, LS174T (a surrogate for PMP cells).|The levels (median, range) of pg/ml of IL-6 (2493, 17.7-9267.97), IL-8 (208, 11.38-8847.03), IP-10 (3771, 72-11892) and MCP-1 (2856, 301-10726) in ascites were significantly elevated compared to serum levels of IL-6 (3.18, 1.41-32.08, p<0.0001), IL-8 (2.66, 1.52-96.94, p<0.0001), IP-10 (439.5, 213-884, p<0.0001) and MCP-1 (422, 143-3347, p=0.0002). Myoepithelial cells showed immunostaining for IL-6 and tumor cells stained faintly and moderately for IP-10 and MCP-1, respectively. Recombinant IL-6 and IL-8, at concentrations found in ascites, did not affect cell growth when measured over 72 hours.|In conclusion, this study has demonstrated high levels of IL-6, IL-8, IP-10 and MCP-1 in the tumor microenvironment of PMP. IL-6 and IL-8 do not affect growth of cells in vitro. Further studies are warranted to explore this dynamic environment in order to better classify this disease and to target treatment.ProQuest Traditional Publishing Optionix, 50 page
"Closing the R&D Gap, Evaluating the Sources of R&D Spending"
No full textBoth spending and tax policies have been implemented in the United States with the goal of stimulating private sector research and development (R&D). Karier questions whether current R&D policy, especially the research and experimentation tax credit, can contribute to closing the gap between nondefense expenditures on R&D in the United States and such expenditures in other countries, such as Japan and Germany. He also explores possible changes to our current R&D policy to make it more effective.
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Energy requirements of adults.
No full textOBJECTIVES: To describe issues related to energy requirements of free living adults and discuss the importance of basal metabolic rate (BMR) and their relationships to total energy expenditure (TEE ) and physical activity level (PAL, derived as TEE/BMR) and to determine the influence of body weight, height, age and sex. DESIGN: Based on a review of the literature, this paper examines the variability in BMR due to methodology, ethnicity, migration and adaptation (both metabolic and behavioural) due to changes in nutritional status. Collates and compiles data on measurements of TEE in free living healthy adults, to arrive at limits and to compare TEE of populations with different life-styles. RESULTS AND CONCLUSIONS: The constancy of BMR and its validity as a reliable predictor of TEE in adults as well as the validity of PAL as an index of TEE adjusted for BMR and thus its use to categorise the physical activity pattern and lifestyle of an individual was confirmed. The limits of human daily energy expenditure at around 1.2 x BMR and 4.5 x BMR based on measurements made in free living adults have been reported in the literature. A large and robust database now exists of energy expenditure measurements obtained by the doubly labelled water method in the scientific literature and the data shows that, in general, levels of energy expenditure are similar to the recommendations for energy requirements adopted by FAO/WHO/UNU (1985). The review also confirms that metabolic adaptation to energy restriction is not an important factor that needs to be considered when recommending energy requirements for adults in developing countries
A temporal typology of entrepreneurial opportunities: implications for optimal timing of entrepreneurial action: Implications for the optimal timing of entrepreneurial action
No full textEntrepreneurial opportunities emerge and dissipate over time, yet little is known about how and why they vary in their ephemerality and what the implications of temporal variance are for the optimal timing of entrepreneurial action. Building on the actualization theory of opportunity and signal processing theory, we propose that profit possibilities exist in the convolution of consumer desire, technical feasibility, and economic viability of an innovation. Conceiving consumer desire – a necessary ingredient of any profit opportunity – as consisting of fleeting or enduring consumer preferences and fixed or variable consumer expectations, we identify four possible distributions of consumer desire over time. We then show how the interaction of these distributions with technical feasibility functions produces a temporal typology of entrepreneurial opportunities. Our analysis suggests that, despite sharing conceptual similarities in structure, each type of opportunity emphasizes a different form of asymmetry across opportunity categories, which is likely to differentially affect the optimal timing of entrepreneurial action. We conclude by pointing out how considerations of time facilitate the move away from fruitless philosophical debates and toward a more theoretically nuanced and empirically informative view of the concept.</p
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