7,614 research outputs found
Education and Training in St. Vincent and the Grenadines: A Partially Annotated Bibliography
Full text linkThis bibliography on “Education and Training in St. Vincent and the Grenadines” has been specifically prepared for the UWI School of Continuing Studies’ St. Vincent and the Grenadines Conference. It covers all aspects of education and training in St. Vincent and the Grenadines including: Academic achievement,economics of education, educational infrastructure, literacy and mathematics education
Dual nuclear roles of an essential scavenger decapping enzyme
No full textThe broad findings of the current work focus on mammalian DcpS and provide an analysis of its role in pre-mRNA splicing, transcription, and its requirement in mouse development. Mutagenesis and heterokaryon assays reveal an N-terminal nuclear localization sequence and a central nuclear export sequence that account for its nucleocytoplasmic dynamics. Cell-based reporter assays reveal two novel DcpS nuclear roles that explain its prevalent nuclear presence. A cell-based mRNA assay, which detects reporter splicing patterns, indicates DcpS knockdown leads to pre-mRNA processing deficiency in the first intron. DcpS or Cbp20 overexpression partially and completely corrects this defect, respectively. Catalytically inactive DcpS displaces the Cbp20-cap interaction by competition in a reconstituted system. These results suggest DcpS is a positive regulator of pre-mRNA splicing and is in line with the idea that DcpS knockdown predictably upregulates intracellular cap structure levels. Another cell-based translation assay, which detects reporter enzyme activity, shows DcpS chemical repression or knockdown stimulates cap-dependent translation and reduces 4EBP1 protein level. The unexpected opposite effect on translation suggests DcpS catalysis does not directly regulate protein synthesis as previously thought. DcpS chemical repression by a competitive inhibitor leads to 4EBP1 and 4EBP2 transcriptional reductions that correlate with their steady state mRNA levels. These results point toward an additional DcpS nuclear role in transcription of specific targets. On a final note, the failure to generate DcpS homozygous progeny as early as 6 days post coitum (dpc) indicates this gene is essential for mouse embryogenesis. DcpS heterozygous intercross yields approximately two heterozygotes for each wildtype during 9.5 dpc and postnatal period. DcpS heterozygotes are normal with respect to fertility. Western blots show DcpS is ubiquitously expressed in an adult tissue panel comprised of brain, liver, kidney, and heart. The present study identifies at least two nuclear roles of DcpS in pre-mRNA first intron splicing and in transcription, and its essential role in mouse development.Ph.D.Includes bibliographical referencesIncludes vitaby Vincent She
Norman Vincent Peale portrait
No full textPortrait of author and minister Norman Vincent Peale, ca. 1984. Peale was born on May 31, 1898, in Bowersville, Ohio. He graduated from Ohio Wesleyan University and became one of the most influential ministers of the twentieth century, known for his dynamic and energetic sermons. He preached an optimistic message that many Americans accepted during such trying events as the Great Depression, World War II, the Cold War, and the Civil Rights Movement. His sermons were broadcast on the radio and shown on television all across the United States. Peale also published forty-six books, his most popular being "The Power of Positive Thinking.
François Vincent
No full textGrandbois introduces Vincent's paintings and prints from 1992 to 1998, analysing the artist's main source of inspiration - the body - while describing his use of the three studios he frequents. Includes a text by Vincent on humour in art. Texts in English, French and Japanese. Biographical notes on artist and author
Kara Gust interviews author Jeff Vande Zande
No full textAuthor Jeff Vande Zande talks about teaching and writing, poems vs. short stories, developing characters in his stories based on his personal experience, and his current projects. Vande Zande is interviewed by Michigan State University Librarian Kara Gust for the MSU Libraries' Michigan Writer Series
The changing role of the university : national aspects : speech [delivered at] Mount Saint Vincent University
No full textSpeech Mount Saint Vincent University by M.O. Morgan, The Changing Role of the University, National AspectsTitle from captio
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