177,489 research outputs found
PQBP1 promotes translational elongation and regulates hippocampal mGluR-LTD through suppressing eEF2 phosphorylation. Shen et al.
No full textTranslation elongation controls the efficiency and accuracy of protein synthesis. Shen et al. discover that the intellectual disability-associated protein PQBP1 regulates translation elongation through direct interaction with eEF2, protecting it from phosphorylation. Loss of PQBP1 in the hippocampal neurons impairs metabotric glutamate receptor-induced long term depression and associated behaviors
Face recognition using linear representation ensembles
No full textAbstract not availableHanxi Li, Fumin Shen, Chunhua Shen, Yang Yang, Yongsheng Ga
PQBP1 promotes translational elongation and regulates hippocampal mGluR-LTD through suppressing eEF2 phosphorylation. Shen et al.
No full textTranslation elongation controls the efficiency and accuracy of protein synthesis. Shen et al. discover that the intellectual disability-associated protein PQBP1 regulates translation elongation through direct interaction with eEF2, protecting it from phosphorylation. Loss of PQBP1 in the hippocampal neurons impairs metabotric glutamate receptor-induced long term depression and associated behaviors
Frames de Gabor: el principio de dualidad de Ron y Shen
Full text link[EN] We introduce the frame theory and the ir relationship with Riesz bases. We focus on the study of Gabor frames and conclude with the Ron-Shen duality principie[ES] Introducimos la teoria de frames y su relación con las bases de Riesz. Nos centramos en el estudio de los frames de Gabor y llegamos al principio de dualidad de Ron y Shen.
RESUMEN
(esoañol)Primo Tárraga, E. (2014). Frames de Gabor: el principio de dualidad de Ron y Shen. Universitat Politècnica de València. https://riunet.upv.es/handle/10251/53355Archivo delegad
Shen ren tong ju de shi jie Zhongguo ren yu Zhongguo ci shen wen hua
No full textBen shu fen xi le ci shen shi jie chan sheng de she hui li shi gen yuan yi ji ta dui zhong guo she hui li shi suo chan sheng de ying xiang, lun shu le yan jiu ci shen wen hua de xian shi yi y
Optimal resonator damping for wave propagation control in mechanical metamaterials
No full textA novel approach to the optimal damping of linearly damped resonators embedded in metamaterial systems is proposed with the aim of minimizing the metamaterials’ response when the external excitation frequency lies within one of the bandgaps. The equation governing wave propagation in the metamaterial system is obtained via a Galerkin projection combined with the quasi-periodicity ansatz of the Floquet–Bloch theorem. It is shown that an optimality criterion can be obtained for the resonator damping for any excitation frequency by extending the Den Hartog theory of fixed points in the frequency response functions. A numerical example of a honeycomb metamaterial is discussed to show how the proposed method works in a practical application. A full numerical optimization is carried out to study the quality factor of the metamaterials’ response with respect to the resonator damping ratio while proving its effectiveness. © 2023 Elsevier Lt
Ridge-like upwelling in the uppermost lower mantle beneath eastern Africa from finite-frequency seismic tomography
No full textLa fórmula Shen-Qi-Yan-Shen atenúa la deposición lipídica renal diabética al regular a la baja la expresión de proteoglicanos
Full text linkDiabetic nephropathy (DN) is characterized by renal lipid accumulation, often driven by proteoglycan (PG) interactions with lipoproteins. To investigate the effects of Shen-Qi-Yan-Shen Formula (SQYSF) on DN. Db/db mice were used as an experimental model and divided into different groups: db/m normal control, db/db model, SQYSF-treated, captopril-treated, and SQYSF + captopril-treated groups. Mice were treated with saline, SQYSF, captopril, or SQYSF + captopril for 12 weeks. SQYSF significantly reduced blood glucose, lipid levels, and markers of renal damage (blood urea nitrogen, serum creatinine, urinary albumin) in db/db mice compared to controls. SQYSF downregulated the expression of proteoglycan (PG), apolipoprotein B (apoB), and LDL-receptor in the kidney, suggesting a mechanism that involves reduced lipid accumulation. The protective effects of SQYSF were enhanced when combined with captopril. SQYSF may prevent lipid deposition by modulating PG expression, suggesting its potential as an innovative therapeutic agent for DN.La nefropatía diabética (DN) se caracteriza por la acumulación lipídica renal, a menudo impulsada por interacciones de proteoglicanos (PG) con lipoproteínas. Este estudio investiga los efectos de la fórmula Shen-Qi-Yan-Shen (SQYSF) sobre la DN. Se utilizaron ratones Db/db como modelo experimental y se dividieron en diferentes grupos: grupo control normal db/m, grupo modelo db/db, grupo tratado con SQYSF, grupo tratado con captopril y grupo tratado con SQYSF + captopril. Los ratones fueron tratados con solución salina, SQYSF, captopril o SQYSF + captopril durante 12 semanas. La SQYSF redujo significativamente los niveles de glucosa en sangre, lípidos y marcadores de daño renal (nitrógeno ureico en sangre, creatinina sérica, albúmina urinaria) en ratones db/db en comparación con los controles. La SQYSF reguló a la baja la expresión de proteoglicanos (PG), apolipoproteína B (apoB) y el receptor de LDL en el riñón, sugiriendo un mecanismo que involucra la reducción de la acumulación lipídica. Los efectos protectores de la SQYSF se potenciaron cuando se combinó con captopril. La SQYSF puede prevenir la deposición lipídica al modular la expresión de PG, sugiriendo su potencial como un agente terapéutico innovador para la DN
THREE ESSAYS ON FACTOR MOBILITY
Full text linkThis dissertation consists of three essays on trade policy and factor mobility.
The first essay studies the effects of preferential tariff rates on China's imports from African Least Developed Countries (LDCs). On the second ministerial meeting of China-Africa Cooperation Forum (FOCAC) in 2003, China offered duty-free treatment to 190 products originating from a group of LDCs in Africa, so as to facilitate their entry into the Chinese market. The goal of this essay is to examine whether or not this agreement has some economic content. Based on detailed import data at the 6-digit harmonized system level, we employ a triple-difference (DDD) approach to empirically investigate the effects of preferential tariff rates on Chinese imports from African LDCs. The estimation results show that, on average, there is no evidence that duty free access helped African LDCs effectively gain access to the Chinese market in the years following the initial implementation of this policy. However, we do find that there is an increase of imports in the last year of our sample, suggesting that the impact is growing over time. We also find that agricultural goods experience the largest increase in import values, while imports of textile goods are still relative low.
The second essay investigates the impact on China's economic growth of the State-Sponsored Study Abroad Programmes (SSSAP). It is widely believed that human capital has played a crucial role in the Chinese economic miracle. In recent years, the Chinese government has launched a series of SSSAP as to further improve domestic human capital through foreign training. In this essay, we explore the effects of such programs on China's economic growth in a Lucas-type endogenous growth model with human capital accumulation. We first derive the growth-maximizing tax rate on output which is used to finance public spending on education. Next, we determine the optimal share of educational expenditure between home-educated and foreign-educated human capital, taking tax rate on output as given. Due to the complexity of the model, we also carry out a series of numerical simulations to examine the effect of SSSAP on Chinese economic growth.
In the third essay, we study the European citizens' preferences concerning the allocation of power between European Union (EU) and Member States in the domain of immigration policy. We first develop a simple framework to show that (i) harmonization of immigration policies is likely to lead to a more liberal immigration policy; (ii) there exists a strong relationship between EU citizens' education levels and their supports for delegating competences to the EU institutions in the field of immigration. Using several rounds of Eurobarometer surveys carried out between 2000 and 2008, we test the theoretical predictions, and find that on average education level has a positive, statistically significant impact on natives' preferences over a common immigration policy. In addition, we find that self-reported political orientation and overall perception of the European Union also affect natives' attitudes towards the harmonization of immigration policy
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