186 research outputs found
Alternative therapy in glaucoma management: Is there any role?
No full textGlaucoma is one of the leading causes of blindness worldwide. Various randomized controlled clinical trials have shown that lowering intraocular pressure (IOP) does reduce progression of primary open-angle glaucoma. However, there is lots of interest in nonpharmacological options that includes lifestyle adjustment and alternative and complementary therapy (ACT). At least 5% glaucoma population uses ACT. Various lifestyle activities like exercise and alcohol can reduce IOP by 1 to 2 mm Hg but would have small effect on glaucoma. The psychological stress can increase IOP. Hypothetically and few studies do show neuroprotective effect (or effect on ocular blood flow) of alcohol, Gingko biloba, bilberry, but the current evidence is weak for its routine use. We must also remember the side effects of ′medications′ (e.g., marijuana, alcohol) before promoting as remedy for glaucoma. In current armamentarium of glaucoma management, ACT cannot substitute the conventional treatment available to lower IOP
Ovarian steroid cell tumor in pregnancy-a rare occurrence: Report of a case and review of the literature
No full textBackground: Steroid-cell tumors of the ovary are very rare, especially during pregnancy, and they must be distinguished from luteoma of pregnancy.
Case: An 18-year-old female, gravida 3, para 1-0-1-1, at 38 weeks' of gestation, had an adnexal mass that was discovered incidentally during a Caesarean section. The tumor was excised and her male infant was normal.
Results: Histologic workup revealed the tumor to be a steroid-cell tumor, which is exceedingly rare in pregnancy.
Conclusions: Ovarian steroid-cell tumors, which are malignant one-third of the time, are difficult to distinguish from luteoma of pregnancy.Peer reviewe
Gender and climate change framework for analysis, policy & action
Get PDF"This paper by Jyoti Parikh provides a framework to anlayse gender and climate change concerns keeping in view the strengths and vulnerability of poor ‐ women in particular. The author also provides policy recommendations for policies and actions.
The Neuropeptide VGF is Reduced in Human Bipolar Postmortem Brain and Contributes to Some of the Behavioral and Molecular Effects of Lithium
No full textRecent studies demonstrate that the neuropeptide VGF (non-acronymic) is regulated in the hippocampus by antidepressant therapies and animal models of depression and that acute VGF treatment has antidepressant-like activity in animal paradigms. However, the role of VGF in human psychiatric disorders is unknown. We now demonstrate using in situ hybridization that VGF is downregulated in bipolar disorder in the CA region of the hippocampus and Brodmann’s Area 9 (BA9) of the prefrontal cortex. The mechanism of VGF in relation to LiCl was explored. Both LiCl intraperitoneally (IP) and VGF intracerebroventricularly (ICV) reduced latency to drink in novelty-induced hypophagia and LiCl was not effective in VGF+/- mice suggesting that VGF may contribute to the effects of LiCl in this behavioral procedure that responds to chronic antidepressant treatment. VGF by intrahippocampal injection also had novel activity in an amphetamineinduced hyperlocomotion assay thus mimicking the actions of LiCl injected IP in a system that phenocopies manic-like behavior. Moreover, VGF+/- mice exhibited increased locomotion following amphetamine and did not respond to LiCl, suggesting that VGF is required for the effects of LiCl in curbing the response to amphetamine. Finally, VGF by ICV in vivo activated the same signaling pathways as LiCl and is necessary for the induction of MAPK and AKT by LiCl thus lending insight into the molecular mechanisms underlying the actions of VGF. The dysregulation of VGF in bipolar disorder as well as the behavioral effects of the neuropeptide similar to LiCl suggests that VGF may underlie the pathophysiology of bipolar disorder.Peer reviewe
Assessing the effect of exercise on dial-task cognitive impairment in patients with Parkinson's disease
No full textThis work was produced while the author was an undergraduate student in the Summer Research Institute of the Ronald E. McNair Post Baccalaureate Degree Achievement Program at Rutgers University
Examining mechanical properties of single acetaminophen crystal using nanoindentation methods
No full textThe pharmaceutical industry incurs substantial loss in revenue and consumer confidence with inefficient manufacturing practices. Large scale processing of organic compounds is challenging due to its sensitivity to environmental conditions and the unpredictable breakage behavior of tablets under applied stress. Tablet compaction and particle size reduction through milling induces variability in the end product. Variability in powder flow, stress induced transformation in polymorphic compounds, re-crystallization after compaction, and lack of content uniformity are some factors that translate into poor product quality. These challenges can be partially resolved by a better understanding of mechanical properties of crystalline pharmaceutical materials at single particle level. The endeavor of this study was to understand the breakage behavior of various planes of a single Acetaminophen crystal using nanoindentation instrumentation. The results of the study indicated that the Acetaminophen crystal is anisotropic with respect to hardness and Young’s modulus values. Analysis of the load-depth curve, discontinuities on the loading and unloading cycle were observed, as well as pop-in events during constant load intervals. Furthermore, the frequency of pop-in events on the loading depth curve was found to correlate with the elasticity of the planes in question. It was also apparent that the organic compound was sensitive to environmental conditions. Varying strain rates effects different planes of the same crystal and also in adhesion reflected sensitivity to environmental conditions. The exact mechanism by which the crystal deforms is still unknown. However it is theorized that it could be through partial dislocations and crack propagations.M.S.Includes bibliographical referencesby Hiral Parik
Generalized Einstein’s Equations from Wald Entropy
Get PDFWe derive the gravitational equations of motion of general theories of gravity from thermodynamics applied to a local Rindler horizon through any point in spacetime. Specifically, for a given theory of gravity, we substitute the corresponding Wald entropy into the Clausius relation. Our approach works for all diffeomorphism-invariant theories of gravity in which the Lagrangian is a polynomial in the Riemann tensor
Comparison of microwave and conventional frying on quality attributes and fat uptake in potatoes
Get PDFOil content is an important quality attribute in fried products. Oil uptake is influenced by several interdependent factors that define the final oil content in a fried product. In this study microwave frying was investigated for its potential in reducing fat content of fried foods. A comparative analysis of moisture, fat, color and texture was done for conventional and microwave fried French fries. Experiments were performed in triplicate for both frying operations at temperatures of 177°C, 185°C and 193°C for time duration's of 60, 90 and 120 seconds. Decrease in moisture content was observed with frying time, but moisture did not significantly differ between the two frying operations. Fat reduced by 0.08 g/g solids at 185°C and by 0.07 g/g/ solids at 193°C for 120 sec microwave frying compared to conventional frying. The lightness parameter (L*) decreased to a lesser extent in microwave frying than conventional frying. The real-time pressure and temperature profiles indicated that during microwave frying, gage pressure had greater magnitudes and the temperature increased to boiling point at a faster rate for microwave frying compared to conventional frying. Negative gage pressures had higher magnitudes and lasted longer during conventional frying than microwave frying. Higher magnitude of positive gage pressure for longer frying duration and lower magnitude of negative pressure in microwave frying than conventional frying is expected to have caused lower fat uptake with the former frying method than the latter. For conventional frying, there were no significant differences in the elastic modulus for all frying temperatures and frying times. Whereas for microwave frying, significantly lower magnitudes of G(t) were observed at 177°C for 90 secs frying time compared to 60 secs and 120 secs at the same temperature. Significantly lower magintudes of G(t) values for MF were also observed at 185°C for 120 secs frying time compared to 60 and 90 secs at the same temperature. Consumer test confirmed that reduced fat uptake during microwave frying did not compromise with desirable attributes of French fries.Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2018-05-01The student, Archana Parikh, accepted the attached license on 2016-04-22 at 14:18.The student, Archana Parikh, submitted this Thesis for approval on 2016-04-24 at 15:06.This Thesis was approved for publication on 2016-04-28 at 08:02.DSpace SAF Submission Ingestion Package generated from Vireo submission #9442 on 2016-07-07 at 14:17:55Made available in DSpace on 2016-07-07T21:18:01Z (GMT). No. of bitstreams: 2
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Unusual presentation in Axenfeld-Rieger syndrome
No full textWe report an unusual presentation of a case of Axenfeld-Rieger (A-R) syndrome. A 14-year-old male presented with gradual dimness of vision for 1 year and redness of left eye for 3 days. The patient had megalocornea with Haab's striae in the right eye and posterior embryotoxon in both the eyes. In the left eye, there was a white cord-like structure traversing the anterior chamber with adhesions to iris tissue along its course. On two antiglaucoma medications, his intraocular pressure (IOP) was 22 mm Hg in the right eye and 18 mm Hg in the left eye. Gonioscopy revealed a cord-like structure originating at the level of Schwalbe's line. He underwent right eye trabeculectomy with mitomycin-C. This case highlights a rare presentation of a strange cord-like structure, a rare presentation of A-R syndrome
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