5,291 research outputs found
sj-docx-1-cjk-10.1177_20543581221084499 – Supplemental material for Patient and Clinician Perspectives on the use of Remote Patient Monitoring in Peritoneal Dialysis
No full textSupplemental material, sj-docx-1-cjk-10.1177_20543581221084499 for Patient and Clinician Perspectives on the use of Remote Patient Monitoring in Peritoneal Dialysis by Benjamin Talbot, Sara Farnbach, Allison Tong, Steve Chadban, Shaundeep Sen, Vincent Garvey, Martin Gallagher and John Knight in Canadian Journal of Kidney Health and Disease</p
Circulating human progenitor cells - the sentinels of vascular repair?
No full textAbstract P.1.3Sarah L. Brice, Emma Thompson, Michaelia P. Cockshell, Shaundeep Sen, Claudine S. Bonde
Sen-Lab-LMS/Senescence_nuclear_features: Publication_version_2.0
No full text<p>Author checklist.</p>
The Contributions of Professor Amartya Sen in the Field of Human Rights
No full textThis paper analyses the work of the Nobel Prize winning economist Professor Amartya Sen from the perspective of human rights. It assesses the ways in which Sen's research agenda has deepened and expanded human rights discourse in the disciplines of ethics and economics, and examines how his work has promoted cross-fertilisation and integration on this subject across traditional disciplinary divides. The paper suggests that Sen's development of a 'scholarly bridge' between human rights and economics is an important and innovative contribution that has methodological as well as substantive importance and that provides a prototype and stimuli for future research. It also establishes that the idea of fundamental freedoms and human rights is itself an important gateway into understanding the nature, scope and significance of Sen's research. The paper concludes with a brief assessment of the challenges to be addressed in taking Sen's contributions in the field of human rights forward.Amartya Sen, human rights, poverty, freedom, obligation, capability approach, meta-rights, entitlements, opportunity freedom, liberty-rights
Inequalities, Agency, and Well-being: Conceptual Linkages and Measurement Challenges in Development
No full textdevelopment, inequality, gender, well-being, agency, capability, distribution, Sen
Endothelial progenitor cells, uraemic toxins, and the development of endothelial dysfunction in chronic kidney disease.
No full textMorbidity and mortality rates for cardiovascular disease (CVD) are increased among end stage kidney disease (ESKD) patients receiving dialysis treatment, and not corrected with kidney transplantation (KTx). Classic CVD risk factors do not fully predict the increased risk, with novel factors causing endothelial dysfunction (ED), leading to arteriosclerosis, congestive heart failure (CHF) and sudden death, key to disease pathogenesis. These novel factors include bone marrow (BM) derived endothelial progenitor cells (EPCs), which have key roles in maintenance, repair and growth of the endothelium. There is limited data about the role of EPCs and CVD in the ESKD population. This uraemic milieu includes p-cresol (sulfate, PC/S) and indoxyl sulfate (IS), toxins associated with CVD in ESKD. In this thesis, the relationship between CVD and ESKD, and the potential role of EPCs and uraemic toxins was examined from epidemiological, clinical and laboratory perspectives. Data was obtained for the period between 2002-2007 for all hospital separations in Australia. Analysis was performed based on ICD-9/10 coding. This showed (for the first time in an Australian population): (i) an increase in risk for CVD hospital separations among dialysis and KTx, with higher rates for CHF than acute cardiac events (ACE); (ii) an advantage for KTx recipients in regards to ACE, but not CHF hospital separations, over dialysis recipients, and (iii) for CHF, no increase in in-hospital mortality, or length of stay per separation for any ESKD group compared to controls. At a clinical level, in groups of haemodialysis (HDx), KTx patients and controls, low peripheral blood (PB) EPC numbers were correlated with surrogate markers of CVD and ED. No clear relationship of IS and PC/S with ED was seen (although study power was limited). For in vitro studies, techniques were developed for isolation (Flow sort and AutoMACS), enumeration (FACS) and culture expansion of EPCs from BM and umbilical cord blood samples. The effects of uraemic serum and toxins PC and IS on cultured endothelial cells (ECs) and EPCs in vitro was examined, as a model of vascular pathology in ESKD. Greater HUVEC VCAM-1 expression and reduced tube formation in Matrigel were observed in response to increasing PC concentration than IS. The effect of IS (but not PC) at higher concentration in Matrigel was reduced by the addition of EPCs. Akt/ERK expression by western blot, cell migration to VEGF, and supernatant investigation by FlowCytoMix for soluble cell surface markers, were also performed. Testing of HUVEC function post-exposure to sera from control, transplant and HDx recipients did not replicate the above results on the basis of sera PC and IS levels. In summary, this thesis has explored the increased burden of CVD in ESKD patients in Australia, the relationship of EPCs, both in vivo and in vitro, to vascular disease in this setting, and the role of uraemic toxins as agents for CVD. These results underline why certain therapies may not be effective in the ESKD population for CVD prevention, and suggest novel approaches are needed.Thesis (Ph.D.) -- University of Adelaide, School of Medicine, 201
OVERCOMING POSITIVISM IN ECONOMICS: AMARTYA SEN'S PROJECT OF INFUSING ETHICS INTO ECONOMICS
No full textLogical Positivism, which arose in philosophy early in the twentieth century, proclaimed the sharp distinction between facts and values. Despite objections at the time, positivism was imported into economics in the 1930s. Over time, objections lessened; economics was transformed and ethical considerations were driven out of its core. In the 1950s, debates about positivism arose within the discipline which had exported it. According to the American philosopher Hilary Putnam, the fact/value distinction is now discredited in philosophy. If that is so, the methodological foundations of contemporary economics are also discredited. In this article I examine Amartya Sen’s moral science of economics. First, I will present his historical account of the connections between economics and ethics. Sen claims that there was a close connection between the two until positivism was imported. Second, I will sketch some of Sen’s ethical objections to modern economics, which is still suffering from positivism. Finally, I will lay out some of his ideas on how economics can be returned to an ethical path. Once the ground has been cleared of positivism, ethics can re-emerge in economics in various ways. One path has been marked out by Sen.Teaching/Communication/Extension/Profession,
Incorporation of endothelial progenitor cells into mosaic pseudoislets
No full textData source: Supplemental material, http://www.tandfonline.com/doi/suppl/10.4161/isl.3.3.15392?scroll=top
Link to a related website: https://www.tandfonline.com/doi/pdf/10.4161/isl.3.3.15392?needAccess=true, Open Access via UnpaywallPancreatic islet transplantation is limited by extensive apoptosis and suboptimal function of the implanted islets in the longer term. Endothelial progenitor cells (EPC) may be ideal for enhancing both the survival and function of transplanted islets. Here, we describe for the first time the in vitro formation of rat mosaic pseudoislets comprised of pancreatic β-cells with interspersed vasculogenic EPC. Bone marrow-derived EPC displayed a similar phenotype to non-adherent EPC, recently described in the human and mouse. Mosaic pseudoislet formation was enhanced by the use of an embryoid body forming medium (BPEL) and a spin protocol. Mosaic pseudoislets maintained function in vitro and may represent an enhanced cell therapy delivery approach to enhance the survival and revascularisation of transplanted islets.Daniella Penko, Daisy Mohanasundaram, Shaundeep Sen, Christopher Drogemuller, Claire Mee, Claudine S. Bonder, P. Toby H. Coates and Claire F. Jessu
Adventure Tourism and its Future Potential in Ha Tinh, Vietnam
No full textDue to the lack of information about adventure tourism, the client of the thesis, Thanh Sen Travel was not consider adventure tourism as the product of the company. With the belief that Ha Tinh was a potential city to develop adventure tourism, the purpose of the thesis was to investigate the possibility and potential of the city. Therefore, the thesis would provide the company with more information about adventure tourism, identified potential locations and customer segments. The author wanted to persuade the company to add adventure tourism as a new feature to attract new customers coming to the region.
In addition to secondary sources, primary sources were collected via individual qualitative interview of 9 travelers to find a potential target tourist group. Thanh Sen Travel helped the author in discussing the potential adventure tourism activities as well as giving local data to help with the completion of the thesis
Spectral characteristics for a spherically confined- a/r+ br2 potential
No full textSource type: Electronic(1
- …
