351 research outputs found
Extramedullary Relapse of Acute Promyelocytic Leukaemia (APL) at an Unusual Site (External Auditory Canal)
No full textThis is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work
is properly cited, the use is non-commercial and no modifications or adaptations are made.
© 2025 The Author(s). eJHaem published by British Society for Haematology and John Wiley & Sons Ltd
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Aflame ::learning from silence /
No full text"From the bestselling author of The Art of Stillness, a revelatory exploration of the abiding clarity and calm to be found in quiet retreat. Pico Iyer has made more than 100 retreats over the past three decades to a small Benedictine hermitage, high above the sea in Big Sur, California. He's not a Christian-or a member of any religious group-but his life has been transformed by these periods of time spent in silence. That silence reminds him of what is essential and awakens a joy that nothing can efface. It's not just freedom from distraction and noise and rush: it's a reminder of some deeper truths he misplaced along the way. In Aflame, Iyer connects with inner stillness and joy in his many seasons at the monastery, even as his life is going through constant change: a house burns down, a parent dies, a daughter is diagnosed with cancer. He shares the revelations he experiences, alongside wisdom from other non-monastics who have learned from adversity and inwardness. And most profoundly, he shows how solitude can be a training in community and companionship. In so doing, he offers a unique outsider's view of monastic life-and of a group of selfless souls who have dedicated their days to ensuring there's a space for quiet and recollection that's open to us all. Radiant, intimate and gripping, Aflame offers ageless counsel about the power of silence, and what it can teach us about how to live, how to love and, ultimately, how to die"-
miR-125b toggles dynamics and structure of dendritic filopodia in developing hippocampal neurons
No full textThe wiring of the nervous system is an intricate process of self-organization, of unparalleled complexity in the natural world. To get a sense of the scope of the requirement, imagine all the billions of phones and computers connected by wires to form the internet. Imagine if these wires branch out and divide, avoiding inimical landscapes and waters, to reach the right servers and computers, which turn had to send out wires to meet yet other servers and so on, till you have the internet of today. Now imagine that instead of a few billion computers, you had eighty-six billion neurons. Instead of men laying down the wiring on pre-programmed routes, the wires had to grow on their own. And instead of the lands and seas of Earth, you had to achieve all this in the space of a single human skull. This is the self-organization challenge of the axons and dendrites of the brain.
Developing dendrites encounter a variety of stimuli that direct their growth and final architecture. Cellular substrates respond to these stimuli, integrating extrinsic information to direct dendritic growth. Of interest in this process are microRNAs, small noncoding RNAs around 22 nucleotides long, which can reversibly repress local translation in dendrites. By responding to external cues sensed by dendritic filopodia, they participate in the key decision-making processes in developing dendrites: where and how to grow.
This study focuses on the role of miR-125b, a brain abundant microRNA, for its role in the dynamics and structure of filopodia in developing dendrites. We inhibited miR- 125b’s activity in cultured hippocampal neurons during the early stages of development as filopodia explore their microenvironment. We show that miR-125b function is critical for maintaining the structural features of filopodia, and that inhibiting its function changes the distribution of the type of protrusions emerging from dendritic shafts. Inhibiting miR-125b increases dendritic expression and localization of the GluN2A subunit of the NMDA receptor, and we show that dendritic GluN2A is correlated with maintaining filopodial morphology. Using Spatial Light Interference Microscopy (SLIM), we show that miR-125b function contributes to maintaining the dynamicity of filopodia. We propose that miR-125b is critical in maintaining the filopodial phenotype early in dendrite development, thus contributing to dendritogenesis and spinogenesis. Through its regulation of GluN2A, miR-125b shapes neuronal response to the synaptotrophic factor glutamate. These high-resolution analyses reveal fresh insights into the process by which neurons integrate multiple external signals to establish the correct connections. Such insights are critical to understanding the implicated role of miR125b in various neurological disorders like Fragile X Syndrome and Alzheimer’s disease.Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2020-05-01The student, Rajashekar Iyer, accepted the attached license on 2018-04-13 at 23:18.The student, Rajashekar Iyer, submitted this Dissertation for approval on 2018-04-13 at 23:35.This Dissertation was approved for publication on 2018-04-15 at 09:28.DSpace SAF Submission Ingestion Package generated from Vireo submission #12247 on 2018-08-31 at 17:29:01Made available in DSpace on 2018-09-04T20:47:14Z (GMT). No. of bitstreams: 4
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Reenvisioning Sexual Ethics: A Feminist Christian Account
No full textA profound feminist Christian reframing of sexuality examines contemporary social practices and ethical sexFrom the sexual abuse crisis in the Roman Catholic Church to the US Supreme Court decision outlawing state-level bans on same-sex marriage, it has become clear that Catholics and other Christians cannot afford to downplay sex or rely on outdated normative understandings of its moral contours. Feminist theological approaches offer a way forward by considering not just what we should do in sexual spheres but also what sort of sexual people we should aspire to be.In Reenvisioning Sexual Ethics, author Karen Peterson-Iyer adopts a feminist Christian anthropological framework to connect robust theological and ethical analysis to practical sexual issues, particularly those confronting college-aged and younger adults today. The book examines four divergent yet overlapping contemporary social practices and phenomena wherein sex plays a central role: “hookup” culture; “sexting”; sex work; and sex trafficking. Through these case studies, Peterson-Iyer shows that ethical sex is best demarcated not as a matter of chastity on the one hand and purely free consent on the other, but rather as ideally expressing the fullness of human agency, communicating the joy of shared pleasure, and conferring a deep sense of possibility and wholeness upon all participants.This feminist Christian framework will help facilitate frank and profound discussions of sex, enabling young adults to define themselves and others not by hypersexualized and gendered social norms or attitudes but by their fundamental status as dignified and beloved by God.https://scholarcommons.scu.edu/faculty_books/1570/thumbnail.jp
Is Organic Beef Really Different from Non-Organic?
No full textOrganic cattle are processed in the same way as non-organic cattle and there are chemical additives in organic beef that people should be aware of.Fall 2012 PMAccompanied by video fil
From childhood to nationhood: memory, media and malevolence
No full textThis talk explicates the entangled relationship between childhood and nationhood in the Indian context through the analysis of two key events in modern Indian history. The current right-wing nationalist discourse in India espouses an ethnonationalist identity that relies on a unitary logic of race, religion, land, and language. This logic is founded upon Savarkar’s slogan of “Hindi, Hindu, Hindustan” that valorizes not only the Hindu religion but also the Aryan race, the Hindi language, and the land beyond the river Indus. Children and young people are perceived to be the crucible of this Hindu nation that (supposedly) rightfully belongs to the Hindu Brahmanical Hindi-speaking Aryan male. This presentation aims to show how history, narrativity and performance have been deployed to center the figure of the child as well as real children (and youth) as critical players of the Neo-Hindutva discourse. Through a combination of field evidence, secondary literature and media sources, this poster shows how stories and memories are instrumental in the production and propagation of nationalist discourses to children and young people. The talk expounds different tactics such as distorting history, maneuvering memory and rewriting myths that are deployed within the private spaces of homes, the public spaces of schools and neighborhoods and mediatized spaces of movies, through which children imbibe as well as disseminate the idea of India as a Hindu nation.This work was accepted to the annual Graduate Research and Creative Works Symposium while the author was a graduate student at Rutgers University-Camden
Characterization of germ cell development in free-living and parasitic flatworms
No full textSexually reproducing organisms must ensure correct specification and maintenance of germ cells for species survival. Germ cells must be carefully protected from inappropriate differentiation while simultaneously maintaining their identity as highly specialized totipotent cells. Several germ cell-intrinsic mechanisms, including transcriptional and post-transcriptional regulation, are key to executing germ cell-specific processes. Study of molecules necessary for the proper specification, maintenance, and differentiation of germ cells can lead to a deeper understanding of mechanisms underlying totipotency, infertility, tumorigenesis, evolutionary development, and even pathogenesis. Here we study germ cells in the context of both free-living and parasitic flatworms. We use the freshwater planarian Schmidtea mediterranea to understand the functions of germ cell-specific genes crucial for the development and proliferation of early male germ cells. Additionally, we also characterize genes essential for the tremendous reproductive output of the parasite Schisosoma mansoni, a causative agent of the a major neglected tropical disease, schistosomiasis.
It was recently shown that in S. mediterranea, a male germ cell-specific component of the ubiquitous Nuclear Factor-Y family of transcription factors, NF-YB, is necessary for testis maintenance. In Chapter 2, we characterize the cellular mechanism behind NF-YB-mediated maintenance of the male germline stem cells, known as spermatogonial stem cells, or SSCs. We demonstrate that NF-YB is not necessary for the specification of germ cells, but plays a role in the self-renewal and proliferation of SSCs. Furthermore, we show that other components of the NF-Y complex in S. mansoni are similarly necessary for the proliferation of male germ cells, indicating molecular and functional conservation of this family of transcription factors.
Next, we characterize the planarian homologs of boule, which belongs to a family of RNA-binding proteins known to play important roles in human infertility. In Chapter 3, we adopt an evolutionary-developmental approach and show that unlike other invertebrate boule genes, one of the planarian boule paralogs is required for SSC maintenance. Intriguingly, this early germ cell function, thought to be specific to vertebrate representatives of this gene family, appears to have evolved independently and earlier than previously thought. Our results demonstrate that the planarian can be a tractable invertebrate model system for understanding the germ cell functions of genes that are conserved between planarians and vertebrates.
Finally, in Chapter 4, we perform an unbiased transcriptomic screen to identify genes necessary for germ cell development in the parasite S. mansoni. The prodigious egg laying capacity of these parasites is the cause behindunderlies the morbidity of the disease schistosomiasis. Using a large-scale RNA interference-based functional approach, we identify genes functioning in different stages of schistosome male gametogenesis, as well as genes necessary for egg production in the mammalian host.
Together, our studies uncover novel roles for numerous genes critical for germ cell development in free-living and parasitic flatworms.Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2019-08-01The student, Harini Iyer, accepted the attached license on 2017-07-11 at 12:09.The student, Harini Iyer, submitted this Dissertation for approval on 2017-07-11 at 12:17.This Dissertation was approved for publication on 2017-07-12 at 10:28.DSpace SAF Submission Ingestion Package generated from Vireo submission #11397 on 2017-09-29 at 11:18:30Made available in DSpace on 2017-09-29T16:39:43Z (GMT). No. of bitstreams: 2
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Closed-form solutions for the analysis of artificial dielectric layers under generic field incidence
No full textWe present an analytical method to model artificial dielectric layers (ADLs) of finite height. Starting from the closed-form solution for the scattering from a single layer under plane wave illumination, the formulation is extended to the multi-layer case, by including the higher-order interaction between parallel layers in analytical form. The method can be used to describe the radiation of a source located in the close proximity of the ADL. Experimental data obtained from a prototype demonstrator are presented and show a good agreement with the results of the theoretical analysis.Accepted author manuscriptTera-Hertz Sensin
The regularizing effects of resetting in a particle system for the Burgers equation
No full textWe study the dissipation mechanism of a stochastic particle system for the Burgers equation. The velocity field of the viscous Burgers and Navier–Stokes equations can be expressed as an expected value of a stochastic process based on noisy particle trajectories [Constantin and Iyer Comm. Pure Appl. Math. 3(2008) 330–345]. In this paper we study a particle system for the viscous Burgers equations using a Monte–Carlo version of the above; we consider N copies of the above stochastic flow, each driven by independent Wiener processes, and replace the expected value with 1/N times the sum over these copies. A similar construction for the Navier–Stokes equations was studied by Mattingly and the first author of this paper [Iyer and Mattingly Nonlinearity 21 (2008) 2537–2553].
Surprisingly, for any finite N, the particle system for the Burgers equations shocks almost surely in finite time. In contrast to the full expected value, the empirical mean 1/N ∑1N does not regularize the system enough to ensure a time global solution. To avoid these shocks, we consider a resetting procedure, which at first sight should have no regularizing effect at all. However, we prove that this procedure prevents the formation of shocks for any N ≥ 2, and consequently as N→ ∞ we get convergence to the solution of the viscous Burgers equation on long time intervals.</p
To be or not to be an author in a publication related to Amazon fires--A Foucauldian dichotomy of author anonymity.
No full textAbstract
In a recent publication on Amazon fires, the acknowledgement section mentions some authors withdrew their names apprehensive of their career growth being stifled. In this short communication , this unusual author anonymity concerning climate change is presented as a Foucauldian dichotomy
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