1,512 research outputs found
Effect of Kinesio Taping on lower back pain
No full textANOTATION Author: Lucie Klesalova Institution: Rehabilition clinic LF in Hradec Kralove Name of the bachelor's thesis: Effects of Kinesio Taping on lower back pain Supervisor: Mgr. Zuzana Hamarova Number of pages: 70 Nuber of annexes: 19 Year: 2015 Key words: kinesiotape, effects of Kinesio Taping, techniques of Kinesio Taping, lowerback pain This bachelor thesis is focused on the theoretical overview of the method of Kinesio Taping. It introduces the effects and ways of kinesiotape applications, it points to the possible indications and contraindications for this method. The practical part examines a set of 15 probands with a lower back pain. The aim was to evaluate whether a single application of kinesiotape could reduce pain in the lower back. The data was collected through questionnaires and kinesiological examination. The results were recorded for better clarity in graphs and tables
Crimp in socialization of people with cerebral palsy
No full textTITLE: Crimp in socialization of people with cerebral palsy AUTHOR: Lucie Falcníková DEPARTMENT: Department of Special Education SUPERVISOR: doc. PaedDr. Vanda Hájková, Ph.D. ABSTRACT: The work is aimed at integration of people with disabilities into society. The aimis to capture and describe one of the most important parts in everyone's lives -integration not only in the class group but also approximation to the socialization into a whole society. The thesis is dividend into two parts.There are theoretical and practical parts. In the theoretical part we can find definitiv of cerebral palsy, its causes, incidence and forms. We also deal with socialization in different areas, whitch most affect the lives of respondents. The last komponent of the theoretical part is the isme of communication of children with cerebral palsy. The practical part describes the methods and results of research which captures socialization of respondents, especially thein perception of socialization. There search methodis a structured interview with open questions. KEYWORDS: Cerebralpalsy, dysarthria, socializationofthechildwithdisabilities, disabiliti, barrier
Application of chromatographic methods for the separation of metabolites of cholesterol
No full textAuthor: Bc. Lucie Tetrevová Title: The application of chromatographic methods for separtion metabolites of cholesterol Language: czech The proposed diploma thesis deals with the development and validation of analytical method for free and esterified cholesterol separation from blood serum and adrenal tissue samples. This method is neccessary due to the different metabolism of free and esterified cholesterol in the body and it enables the research of these particular pathways using stable isotope tracers. The solid phase extraction method was chosen, optimised and validated with following results: precision values 2.14% for serum cholesterol ester, 6.98% for tissue cholesterol esters, 2.91% for serum free cholesterol, 7.48% for tissue free cholesterol, limit of detection 1 mol/l and linear range 1-25 mmol/l were found. The stability of the derivative was tested for 30 days at temperatures 4 C and -25 C. The derivative was found to be stable for the whole time period in both temperatures. Laboratory temperature was not tested due to a high volatility of the solvent used. The developed method was used in experimental studies evaluating the influence of dietary cholesterol and septic shock to cholesterol synthesis rate
Lyme borreliosis
No full textAuthor: Lucie Kohoutova Title: Lyme borreliosis (Diploma thesis) University: Charles University in Prague, Faculty of Pharmacy in Hradec Kralove Field of study: Pharmacy Background: We investigated the presence of Lyme disease in the area of Havlickuv Brod based on laboratory diagnostics of specific or non- specific antibodies in the blood serum and in the liquor. The aim was to define typical laboratory signs of illness and recommend racional methods in diagnosis of Lyme disease. Methods: We used the data from Havlickuv Brod hospital laboratory of immunology. Patients were dividend into the groups according to the results of basic tests (if there were immunoglobulines type M and type G in serum or liquor), sex, age, the day of blood collection, code of diagnosis, patient's doctor and the type of running tests (ELISA, westernblot). These groups were compared. Patients with at least one positive result in basic tests and with any of additional test at the same time were divided in compliance with relations amongst these types of tests. We tried to determine appropriate interval between taking samples during monitoring the dynamics of the disease by contribution- based method. Results: More threatned by Lyme borreliosis are older women and people over the age of fifty- five. The highest number of new..
Relation between dramatic text and inscenation
No full textLucie Kryzová in her thesis addresses the issue of the relation between dramatic text and inscenation. The work is divided into two parts ? theoretical and practical. Firstly, used terminology is defined in the theoretical part. The author deals with crucial theories of Czech theater science (Jiří Veltruský and Otakar Zich?s work). Subsequently, she explores when a controversial relation between dramatic text and scenic piece is created, addresses the directors? apriorism and investigates the question of stylization of visualized theater. The second part has rather personal touch as it deals with author?s personal experience. Lucie tries to apply the findings from the theoretical part in her own work. She describes six semesters of her undergraduate studies of Directory-Dramaturgy
Predicting glaucoma progression using random forests for correlated binary response based on longitudinally collected standard automated perimetry data
No full textIncludes bibliographical references (pages 114-119).Clustered outcomes with longitudinally collected covariates arise frequently in applied research and present difficulties in statistical analysis because of the complex dependence structure. Due to their nonparametric approach and interpretable results, tree-based methods have become some of the most flexible and popular analytic tools for modeling complex data structures. This dissertation is intended to propose new statistical methods used in determining true visual field progression in high-risk ocular hypertension or early glaucoma patients. Traditional tree models such as classification and regression trees (CART) cannot be readily applied to data arising from ophthalmologic studies. This is because data from the two eyes of the same patient are usually correlated. To overcome the analytical difficulty with correlated outcome data, a simplifying approach is to randomly select one eye per patient. Analyses based on a single observation per cluster are convenient in that a standard tree method can be employed. However, the major disadvantage of this approach is a loss of information because half of all the information collected is unused in the analysis. Tree based methods that can incorporate correlated data are much needed because using data from both eyes can provide more power in any statistical hypothesis testing and improve prediction accuracy in a classification problem. In Chapter 1, we give an introduction to tree-based methods and discuss the motivation behind this thesis. It introduces the challenges in managing glaucoma and detecting glaucomatous visual field progression based on standard automated perimetry. In Chapter 2, we propose a classification tree method for correlated binary data by modifying the splitting function of CART. By applying a robust Wald test from the generalized estimating equations (GEE), data from both eyes can be used while adjusting correlation between two eyes of the same patient. Simulations were conducted under a variety of model configurations to investigate the performance of the split criteria. The proposed approach was also applied to data from the perimetry and psychophysics in glaucoma (PPIG) study to look for baseline prognostic indicators for visual field glaucomatous progression. Both traditional CART and the proposed method based on the robust Wald statistic were applied to the PPIG study data. Results based on test sample (a portion of data not used in the model building process) also show improved accuracy when using data from both eyes. In terms of finding important predictors of glaucoma progression, results based on the proposed method were consistent with many locations that have been discussed in the ophthalmology literature to indicate progression risk. In addition, some new test point locations were uncovered that appear to be associated with increased risk of glaucomatous progression. In Chapter 3, we propose an extension of the existing random forests (RF) classification method based on the new tree method from Chapter 2. We then apply the new RF method to the PPIG study data incorporating both baseline and longitudinal covariates. In order to account for the correlated nature of sequential data (i.e., data collected over time), we rectify the pointwise linear regression (PLR) method that is popular in the ophthalmology literature by performing generalized least square (GLS) regression for longitudinal visual field data from each test point location of each eye of each patient. The slopes and the associated p-values for slopes indicate the magnitude and statistical significance of the change in the visual sequence and are used in the RF construction. As can be seen from the results, the application of RF to the PPIG data by incorporating data from both eyes as well as features from the longitudinal data provides improved accuracy for predicting glaucoma progression. In Chapter 4, we further extend the RF method to deal with visual field data that are known to be noisy. We propose a two-step splitting strategy. First, a measurement error, or random effects, model is fit to the longitudinal visual field data from all test points of all eyes of all patients. This model is designed to remove the measurement errors in the visual field data. Second, the true slopes from the random effects model, together with all the clinical and social-economical baseline covariates, are then considered as potential splitting variables to split the node. In addition, we apply the same longitudinal data set from the PPIG study to showcase the improved fit and prediction accuracy. In order to apply the proposed two-step splitting approach to RF, computational efficiency becomes particularly challenging. RF methods have been recognized to be highly effective and ideally suited for parallelization. The final chapter presents a parallel formulation of the proposed method with RF incorporating joint models for correlated binary outcome and longitudinal covariates. We also provide the analysis of the longitudinal PPIG data to demonstrate excellent speedups and scalability. The last chapter provides a summary of this work, noting the novel contributions to the field of work; and gives suggestions for future wor
The Abstract Author
No full textThe Bachelor's thesis focuses on the concept of so called abstract author. It deals with various forms of abstract author's subject developed in literary theory and narratology: scriptor of R. Barthes, implied author of W. Booth, model author of U. Eco or abstract author of W. Schmid. Futher, the differences between the concepts and the polemics that accompany them (Chatman, Rimmon-Kenanová etc.) are reflected
Multivariate Pareto distribution
No full textTitle: Multivariate Pareto distribution Author: Oleksandr Novytskyi Department: Department of Probability and Mathematical Statistics (305. 32- KPMS) Supervisor: RNDr. Lucie Mazurová, Ph.D., Department of Probability and Mathematical Statistics (305. 32-KPMS) Abstract: This bachelor thesis focuses on three methods of constructing multiva- riate Pareto distribution, i.e. multivariate distribution, where marginal distributi- ons are univariate Pareto distributions. We provide survival and density functions for these models, which are used for the numerical studies and valuation of insu- rance product, specifically a yearly life annuity paid to each insured in the group, whose remaining life time is given by the multivariate Pareto distribution. Keywords: multivariate distribution, Pareto distribution, survival function, density, life annuity
One-year outcomes of aflibercept in recurrent or persistent neovascular age-related macular degeneration
No full textPURPOSE:
To evaluate 6-month and 1-year outcomes of every-8-weeks (Q8W) aflibercept in patients with resistant neovascular age-related macular degeneration (AMD).
DESIGN:
Retrospective, interventional, consecutive case series.
METHODS:
Retrospective review of patients with resistance (multiple recurrences or persistent exudation) to every-4-weeks (Q4W) ranibizumab or bevacizumab that were switched to Q8W aflibercept.
RESULTS:
Sixty-three eyes of 58 patients had a median of 13 (interquartile range [IQR], 7-22) previous anti-vascular endothelial growth factor (anti-VEGF) injections. At 6 months after changing to aflibercept, 60.3% of eyes were completely dry, which was maintained up to 1 year. The median maximum retinal thickness improved from 355 μm to 269 μm at 6 months (P < .0001) and 248 μm at 1 year (P < .0001). There was no significant improvement in ETDRS visual acuity at 6 months (P = .2559) and 1 year follow-up (P = .1081) compared with baseline. The mean difference in ETDRS visual acuity compared to baseline at 6 months was -0.05 logMAR (+2.5 letters) and 0.04 logMAR at 1 year (-2 letters).
CONCLUSION:
Sixty percent of eyes with resistant AMD while on Q4W ranibizumab or bevacizumab were completely dry after changing to Q8W aflibercept at the 6-month and 1-year follow-ups, but visual acuity did not significantly improve. Only a third of eyes needed to be switched from Q8W to Q4W aflibercept owing to persistence of fluid; Q8W dosing of aflibercept without the initial 3 monthly loading doses may be a good alternative in a select group of patients who may have developed ranibizumab or bevacizumab resistance
Les savoirs enseignés aux ouvriers
No full textLucie Tanguy
Transmission of knowledge to manual workers.
Beyond ideological reproduction this study analyses the contradictions in the organization of technical curricula provided for the training of manual workers and employees in France. The author highlights the hidden curriculum and the nature of the conflict and relationship with the division of labor.L'analyse menée ici s'inscrit dans un courant qui se propose d'interroger l'institution scolaire dans les termes sous lesquels elle énonce sa fonction première : la transmission des connaissances. Plus précisément, elle cherche : à identifier les savoirs que l'école programme dans l'enseignement technique court, filière qui contribue à former les futurs travailleurs d'exécution ; à examiner les rapports qui peuvent exister entre la réorganisation du procès de formation intervenue dans ce dernier quart de siècle et les grandes tendances de l'évolution du travail ouvrier ; à voir si cette réorganisation n'est en définitive qu'une autre forme de qualification pour l'emploi ou si elle incline vers une qualification sociale plus générale.Tanguy Lucie. Les savoirs enseignés aux ouvriers. In: Sociologie du travail, 25ᵉ année n°3, Juillet-septembre 1983. pp. 336-354
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