218,114 research outputs found

    The sharp A(p) constant for weights in a reverse-Holder class

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    Coifman and Fefferman established that the class of Muckenhoupt weights is equivalent to the class of weights satisfying the "reverse Holder inequality". In a recent paper V. Vasyunin [17] presented a proof of the reverse Holder inequality with sharp constants for the weights satisfying the usual Muckenhoupt condition. In this paper we present the inverse, that is, we use the Bellman function technique to find the sharp A(p) constants for weights in a reverse-Holder class on an interval; we also find the sharp constants for the higher-integrability result of Gehring [7].Additionally, we find sharp bounds for the A(p) constants of reverse-Holder-class weights defined on rectangles in R-n, as well as bounds on the A(p) constants for reverse-Holder weights defined on cubes in R-n, without claiming the sharpness.</p

    Physiological sharp wave-ripples and interictal events in vitro: What’s the difference?

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    Sharp wave-ripples and interictal events are physiological and pathological forms of transient high activity in the hippocampus with similar features. Sharp wave-ripples have been shown to be essential in memory consolidation, while epileptiform (interictal) events are thought to be damaging. It is essential to grasp the difference between physiological sharp wave-ripples and pathological interictal events in order to understand the failure of control mechanisms in the latter case. We investigated the dynamics of activity generated intrinsically in the CA3 region of the mouse hippocampus in vitro, using four different types of intervention to induce epiletiform activity. As a result, sharp wave-ripples spontaneously occurring in CA3 disappeared, and following an asynchronous transitory phase, activity reorganized into a new form of pathological synchrony. During epileptiform events, all neurons increased their firing rate compared to sharp wave-ripples. Different cell types showed complementary firing: parvalbumin-positive basket cells and some axo-axonic cells stopped firing due to a depolarization block at the climax of the events in high potassium, 4-aminopyridine and zero magnesium models, but not in the gabazine model. In contrast, pyramidal cells started firing maximally at this stage. To understand the underlying mechanism we measured changes of intrinsic neuronal and transmission parameters in the high potassium model. We found that the cellular excitability increased and excitatory transmission was enhanced, whereas inhibitory transmission was compromised. We observed a strong short-term depression in parvalbumin-positive basket cell to pyramidal cell transmission. Thus, the collapse of pyramidal cell perisomatic inhibition appears to be a crucial factor in the emergence of epileptiform events

    Sharp, R T, WX10001

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    This record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete. Visit this record in UMA's new catalogue at: https://archives.library.unimelb.edu.au/nodes/view/416287Surname: SHARP. Given Name(s) or Initials: R T. Military Service Number or Last Known Location: WX10001. Missing, Wounded and Prisoner of War Enquiry Card Index Number: 44440.238440 Item: [2016.0049.48548] "Sharp, R T, WX10001

    Sharp, R, 44690

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    This record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete. Visit this record in UMA's new catalogue at: https://archives.library.unimelb.edu.au/nodes/view/416261Surname: SHARP. Given Name(s) or Initials: R. Military Service Number or Last Known Location: 44690. Missing, Wounded and Prisoner of War Enquiry Card Index Number: SEA-4894.238414 Item: [2016.0049.48522] "Sharp, R, 44690

    Sharp, R B, VX40396

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    This record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete. Visit this record in UMA's new catalogue at: https://archives.library.unimelb.edu.au/nodes/view/416284Surname: SHARP. Given Name(s) or Initials: R B. Military Service Number or Last Known Location: VX40396. Missing, Wounded and Prisoner of War Enquiry Card Index Number: 16038.238437 Item: [2016.0049.48545] "Sharp, R B, VX40396

    Sharp, J R, NX50780

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    This record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete. Visit this record in UMA's new catalogue at: https://archives.library.unimelb.edu.au/nodes/view/416275Surname: SHARP. Given Name(s) or Initials: J R. Military Service Number or Last Known Location: NX50780. Missing, Wounded and Prisoner of War Enquiry Card Index Number: 13478.238428 Item: [2016.0049.48536] "Sharp, J R, NX50780

    Sharp, W R G, NX26001

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    This record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete. Visit this record in UMA's new catalogue at: https://archives.library.unimelb.edu.au/nodes/view/416271Surname: SHARP. Given Name(s) or Initials: W R G. Military Service Number or Last Known Location: NX26001. Missing, Wounded and Prisoner of War Enquiry Card Index Number: 1952.238424 Item: [2016.0049.48532] "Sharp, W R G, NX26001

    Letter from William Sharp to William A. Turner, October 10, 1885

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    1 leaf (double-sided)Handwritten letter from William Sharp to William Alfred Turner, October 10, 188

    Letter from William Sharp to William A. Turner, October 10, 1885

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    1 leaf (double-sided)Handwritten letter from William Sharp to William Alfred Turner, October 10, 188

    Sharp, R. Lauriston

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    Memorial Statement for Professor R. Lauriston Sharp, who died in 1993. The memorial statements contained herein were prepared by the Office of the Dean of the University Faculty of Cornell University to honor its faculty for their service to the university
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