4,793 research outputs found
Dataset supporting thesis titled: Investigation of monitoring technologies to deliver ‘Pill-in-the-Pocket’ oral anticoagulation in atrial fibrillation
No full textThis zip file contains the spreadsheets for the following publications:
Chapter 3: 'Pill-in-the-pocket' Oral Anticoagulation Guided by Daily Rhythm Monitoring for Stroke Prevention in Patients with AF: A Systematic Review and Meta-analysis.
Briosa E Gala A, Pope MTB, Leo M, Sharp AJ, Tsoi V, Paisey J, Curzen N, Betts TR.
Arrhythm Electrophysiol Rev. 2023 Mar 2;12:e05. doi: 10.15420/aer.2022.22. eCollection 2023.
Chapter 4: "Real-world" performance of the Confirm Rx™ SharpSense AF detection algorithm: UK Confirm Rx study.
Gala ABE, Pope MTB, Leo M, Sharp AJ, Banerjee A, Field D, Thomas H, Balasubramaniam R, Hunter R, Gardner RS, Wilson D, Gallagher MM, Ormerod J, Paisey J, Curzen N, Betts TR.
J Arrhythm. 2024 Sep 3;40(5):1093-1101. doi: 10.1002/joa3.13124. eCollection 2024 Oct.
Chapter 5: Diagnostic performance of single-lead electrocardiograms from a smartwatch and a smartring for cardiac arrhythmia detection.
Briosa E Gala A, Sharp AJ, Schramm D, Pope MTB, Leo M, Varini R, Banerjee A, Win KZ, Kalla M, Paisey J, Curzen N, Betts TR.Hea rt Rhythm O2. 2025 Mar 26;6(6):808-817. doi: 10.1016/j.hroo.2025.03.019. eCollection 2025 Jun.
Chapter 6: Real-time smartphone alerts during atrial fibrillation episodes with implantable cardiac monitors and wearable devices: SMART-ALERT study.
Briosa E Gala A, Sharp AJ, Pope MTB, Leo M, Varini R, Paisey J, Curzen N, Banerjee A, Betts TR.
Heart Rhythm. 2025 Apr 15:S1547-5271(25)02331-8. doi: 10.1016/j.hrthm.2025.04.015. Online ahead of print.</span
On the AJ Conjecture for Knots
No full textWe confirm the AJ conjecture [Ga2] that relates the A-polynomial and the colored Jones polynomial for hyperbolic knots satisfying certain conditions. In particular, we show that the conjecture holds true for some classes of two-bridge knots and pretzel knots. This extends the result of the first author in [Le2], who established the AJ conjecture for a large class of two-bridge knots, including all twist knots. Along the way, we explicitly calculate the universal SL₂(C)-character ring of the knot group of the (−2, 3, 2n + 1)-pretzel knot, and show it is reduced for all integers n
The present development of the Paola Kansas gas field: with a complete description of tools used in its development, manner of controlling pressure, conducting, distribution and use for domestic and manufacturing purposes
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Previous issue date: 1889"""By AJ Sharp class of 1882 Harrisonville Mo, May 1889""--Half-title"Thesis (M.E.)--University of Illinois, 1889M
Sharp extensions of Bernstein’s inequality to rational spaces
No full textSharp extensions of some classical polynomial inequalities of Bernstein are established for rational function spaces on the unit circle, on K: = R (mod2π), on [−1,1] and on R. The key result is the establishment of the inequality |f ′ ⎧ ⎪ ⎨ ∑ |aj| (z0) | ≤ max ⎪ ⎩ j=
Detained introns are a novel, widespread class of post-transcriptionally spliced introns
No full textDeep sequencing of embryonic stem cell RNA revealed many specific internal introns that are significantly more abundant than the other introns within polyadenylated transcripts; we classified these as “detained” introns (DIs). We identified thousands of DIs, many of which are evolutionarily conserved, in human and mouse cell lines as well as the adult mouse liver. DIs can have half-lives of over an hour yet remain in the nucleus and are not subject to nonsense-mediated decay (NMD). Drug inhibition of Clk, a stress-responsive kinase, triggered rapid splicing changes for a specific subset of DIs; half showed increased splicing, and half showed increased intron detention, altering transcript pools of >300 genes. Srsf4, which undergoes a dramatic phosphorylation shift in response to Clk kinase inhibition, regulates the splicing of some DIs, particularly in genes encoding RNA processing and splicing factors. The splicing of some DIs—including those in Mdm4, a negative regulator of p53—was also altered following DNA damage. After 4 h of Clk inhibition, the expression of >400 genes changed significantly, and almost one-third of these are p53 transcriptional targets. These data suggest a widespread mechanism by which the rate of splicing of DIs contributes to the level of gene expression.National Institutes of Health (U.S.) (Grant R01 GM34277-23)American Cancer Society (Novartis Institutes of Biomedical Research Postdoctoral Research Fellowship)National Cancer Institute (U.S.) (Koch Institute Support (Core) Grant P30-CA14051
Discovery of a single faint AGN in a large sample of z > 5 Lyman break galaxies
No full textAs part of a large spectroscopic survey of z > 5 Lyman break galaxies (LBGs), we have identified a single source which is clearly hosting an active galactic nucleus (AGN). Out of a sample of more than 50 spectroscopically confirmed R-band dropout galaxies at z∼ 5 and above, only J104048.6−115550.2 at z= 5.44 shows evidence for a high ionization potential emission line indicating the presence of a hard ionizing continuum from an AGN. Like most objects in our sample the rest-frame-UV spectrum shows the UV continuum breaking across a Lyα line. Uniquely within this sample of LBGs, emission from N V is also detected, a clear signature of AGN photoionization. The object is spatially resolved in Hubble Space Telescope (HST) imaging. This, and the comparatively high Lyα/N V flux ratio indicates that the majority of the Lyα (and the UV continuum longward of it) originates from stellar photoionization, a product of the ongoing starburst in the LBG. Even without the AGN emission, this object would have been photometrically selected and spectroscopically confirmed as a Lyman break in our survey. The measured optical flux (IAB= 26.1) is therefore an upper limit to that from the AGN and is of order 100 times fainter than the majority of known quasars at these redshifts. The detection of a single object in our survey volume is consistent with the best current models of high redshift AGN luminosity function, providing a substantial fraction of such AGN is found within luminous starbursting galaxies. We discuss the cosmological implications of this discovery
ON THE AVERAGE NUMBER OF SHARP CROSSINGS OF CERTAIN GAUSSIAN RANDOM POLYNOMIALS Communicated by Fraydoun Rezakhanlou
No full textAbstract. Let Qn(x) = n i=0 Aix i be a random algebraic polynomial where the coefficients A0, A1, · · · form a sequence of centered Gaussian random variables. Moreover, assume that the increments ∆j = Aj − Aj−1, j = 0, 1, 2, · · · , are independent, assuming A−1 = 0. The coefficients can be considered as n consecutive observations of a Brownian motion. We obtain the asymptotic behaviour of the expected number of u-sharp crossings, u > 0, of polynomial Qn(x). We refer to u-sharp crossings as those zero upcrossings with slope greater than u, or those down-crossings with slope smaller than −u. We consider the cases where u is unbounded and increasing with n, say u = o(n 5/4 ), and u = o(n 3/2 )
The author, the text, and the (post)critic: notes on the encounter between postcritique and postcolonial criticism
No full textThe article confronts postcolonial criticism with postcritique, a proposal by Rita Felski for a hermeneutic strategy aiming to overcome the limits of critique. Because of its self-reflexivity, its liaison with poststructuralism, and the societal categories it mobilizes, postcritics often see postcolonial criticism as a quintessential example of critique. However, postcolonial authors share similar concerns as postcritics, particularly when warning against any hasty conflation between intellectual work and political commitment. This article argues that the postcritical understanding of critique eschews the connection between critique and the realm of culture, thereby running the risk of doing away with context altogether. In order to account for the frameworks or contexts in which cultural objects are produced, without falling into some of the pitfalls of critique that postcritique aims to counter, the article proposes to look at the figure of the author as a bridge between the individual and the collective, as Edward Said suggests. The article closes with an analysis of several (critical and postcritical) readings of J. M. Coetzee’s The Childhood of Jesus to provide an example of how authorship can enter the interpretive scene through the figure of ‘late style’
Exploring the roles, effectiveness and impact of health information professionals within evidence based practice
No full textThis is the thesis (critical appraisal) component of a PhD by Published Works. The overall submission was a portfolio of ten published papers supported by a critical appraisal focusing on two key areas: an exploration of the roles that Health Information Professionals (HIPs) can play within evidence based practice (EBP) and an exploration of the effectiveness and impact of the traditional supportive role played by HIPs within EBP. The published papers are listed and referenced within this document but not contained within it. The majority are available elsewhere within the University of Salford Institutional Repository.Drawing on a model developed from the library literature, the thesis highlights a wide range of supportive and active roles that HIPs can potentially play within EBP. This model is informed and illuminated by the studies within the portfolio that demonstrate how the author has fulfilled a wide range of these roles in practice, and identified a new role within systematic reviews in health and social care. This demonstrates that HIPs can transfer their skills outside their traditional library and information practice domain, thus extending theirrole and offering a range of professional opportunities.Using a varied range of research methodologies, the thesis also explores the effectiveness and impact of the contribution made by HIPs when using traditional skills to support EBP. Two models are used to illustrate the outcomes to which HIPs contribute. These include improving search skills and providing evidence which can, over the longer term, contribute to policy making and patient care. At present the weight of the evidence presented tosupport these links is weak. Methodological issues and future research that needs to be addressed to improve the strength of the evidence base are therefore highlighted and discussed
The XMM-Newton long look of NGC 1365: uncovering of the obscured X-ray source
No full textWe present an analysis of the extreme obscuration variability observed during an XMM–Newton 5-d continuous monitoring of the active galactic nuclei (AGN) in NGC 1365. The source was in a reflection-dominated state in the first ∼1.5 d, then a strong increase in the 7–10 keV emission was observed in ∼10 h, followed by a symmetric decrease. The spectral analysis of the different states clearly shows that this variation is due to an uncovering of the X-ray source. From this observation, we estimate a size of the X-ray source DS < 1013 cm, a distance of the obscuring clouds R∼ 1016 cm and a density n∼ 1011 cm−3. These values suggest that the X-ray absorption/reflection originates from the broad-line region clouds. This is also supported by the resolved width of the iron narrow Kα emission line, consistent with the width of the broad Hβ line
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