59 research outputs found
Zu jukagirisch łokił ~ łokkił „Pfeil”
No full textThe article deals with the Kolyma-Yukaghir term łokił ~ łokkił “(blunt) arrow”, its possible origin in the context of terms for arrows in other Siberian languages, as well as in that of hunting terminology. The author with others (like K. Vilkuna, N. Poppe etc.) traces it back to Tungus languages and discusses its character as a taboo-word
Sociología de la urbe
No full textAnalysing different aspects of city life during the lapse between the last quarter of last century and our days, the author points out as a remarkable feature, the unsteadiness with which men and professions are joint, upon the basis of competence and affinity, in it, stating the necessity of satisfactorily exploring the social consequences of that unsteadiness; the author also describes the situations of anonymousness and strangeness through which every new member of a large city goes, and with the example of a family illustrates the points of view and proceedings of its members with regard to neighbourhood relationship, social circle and politic and church community. Then the author devotes to urban dwelling, to end with a chapter on urban planning recommending the sociologic approach to this type of investigations. Town must be considered, not individually, but in its functional connection with the boundary, with the region, as a component of a balanced hierarchyAnalysing different aspects of city life during the lapse between the last quarter of last century and our days, the author points out as a remarkable feature, the unsteadiness with which men and professions are joint, upon the basis of competence and affinity, in it, stating the necessity of satisfactorily exploring the social consequences of that unsteadiness; the author also describes the situations of anonymousness and strangeness through which every new member of a large city goes, and with the example of a family illustrates the points of view and proceedings of its members with regard to neighbourhood relationship, social circle and politic and church community. Then the author devotes to urban dwelling, to end with a chapter on urban planning recommending the sociologic approach to this type of investigations. Town must be considered, not individually, but in its functional connection with the boundary, with the region, as a component of a balanced hierarch
Sociología de la urbe
No full textAnalysing different aspects of city life during the lapse between the last quarter of last century and our days, the author points out as a remarkable feature, the unsteadiness with which men and professions are joint, upon the basis of competence and affinity, in it, stating the necessity of satisfactorily exploring the social consequences of that unsteadiness; the author also describes the situations of anonymousness and strangeness through which every new member of a large city goes, and with the example of a family illustrates the points of view and proceedings of its members with regard to neighbourhood relationship, social circle and politic and church community. Then the author devotes to urban dwelling, to end with a chapter on urban planning recommending the sociologic approach to this type of investigations. Town must be considered, not individually, but in its functional connection with the boundary, with the region, as a component of a balanced hierarchyInstituto de Investigaciones Económica
Sociología de la urbe
No full textAnalysing different aspects of city life during the lapse between the last quarter of last century and our days, the author points out as a remarkable feature, the unsteadiness with which men and professions are joint, upon the basis of competence and affinity, in it, stating the necessity of satisfactorily exploring the social consequences of that unsteadiness; the author also describes the situations of anonymousness and strangeness through which every new member of a large city goes, and with the example of a family illustrates the points of view and proceedings of its members with regard to neighbourhood relationship, social circle and politic and church community. Then the author devotes to urban dwelling, to end with a chapter on urban planning recommending the sociologic approach to this type of investigations. Town must be considered, not individually, but in its functional connection with the boundary, with the region, as a component of a balanced hierarch
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An investigation of post-traumatic stress disorder in Central American refugees living in Tucson
No full textThe purpose of this study was to investigate post-traumatic stress disorder among Guatemalan and Salvadoran refugees living in Tucson, Arizona. The questions that guided the study were: (1) Does post-traumatic stress disorder exist among Central American refugees living in Tucson? (2) If so, how does it manifest itself in this population? (3) What counseling or other therapeutic interventions may be helpful for Central Americans experiencing post-traumatic stress disorder? Six Guatemalan and Salvadoran refugees who had reportedly experienced major stressors participated in a semi-structured interview and responded to a health questionnaire based upon post-traumatic stress disorder symptoms. Findings indicate that five out of six participants were experiencing patterns of stress-induced symptoms which were consistent with a DSM III diagnosis of "Post-Traumatic Stress Disorder". Recommendations for intervention with Central American individuals experiencing post-traumatic stress disorder are presented
Lore Bert in Canada : Works on Paper 1985
No full textThe author analyses the geometric characteristics of this German artist's collages. Biographical notes
A study of the need for art education for the academically talented student; containing a survey of such education in the Greater Boston area
No full textThesis (M.F.A.)--Boston UniversityPLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at [email protected]. Thank you.2999-01-0
Neutropenia in cancer patients, risk prediction models of neutropenia, and supportive measures
No full textEpidemiology studies the causes and distribution of population health and disease conditions in defined populations. It identifies risk factors for disease which may help to prevent disease and promote health.
Each year, the American Cancer Society describes the epidemiology of cancer in the USA. Breast cancer and CLL are the most common cancers in women and adults, respectively. European data for CLL are limited. For both cancers, chemotherapy is an important treatment option. But side effects such as neutropenia and infections remain the principal dose-limiting toxicities, which may affect the effectiveness of cancer chemotherapy. Several studies evaluated risk factors for chemotherapy-induced neutropenia (CIN; absolute neutrophil count [ANC] <1.5x10^9/L) and febrile neutropenia (FN; ANC <0.5x10^9/L and oral temperature =38° for more than 1 hour): e.g. older age, recent infection, prior chemotherapy, and planned relative dose intensity greater than 85% of standard chemotherapy dosing. The prophylactic use of granulocyte colony-stimulating factors (G-CSFs) has been shown to be protective.
Based on the above mentioned risk factors, a number of risk prediction models have been developed over the years. Very often, the risk prediction models considered patient-related, tumour-related, treatment-related, or genetic factors. The majority of these models are not validated using an independent dataset. Systematic reviews of G-CSFs to prevent neutropenia are available, but do not include new long-acting G-CSFs or observational study designs.
To address the epidemiology of CLL, the incidence and risk factors of CIN and FN, and to develop and externally validate a risk prediction model for the occurrence of FN including a broad range of risk factors, three quantitative studies were conducted and published. The fourth published study summarised the efficacy, effectiveness and safety of G-CSFs for the prevention of CIN and FN.
For the first study, the author conducted a cohort analysis of the UK Clinical Practice Research Datalink (CPRD) to identify the epidemiology of CLL, the incidence of neutropenia, and changes in medical resource utilisation of CLL patients. Due to limited data regarding the incidence of neutropenia, the study focused on the epidemiology of CLL and medical resource utilisation of CLL patients. The incidence of CLL was 6.2 per 100’000 person-years and remained stable between 2006 and 2011. Medical resource utilisation in CLL patients increased over the time period from 2000 to 2012. Primary care data from the UK CPRD seemed to be valid to determine the incidence of CLL. These data may not reflect the total of medical resource use in CLL patients as chemotherapy and treatment of related complications such as infections and neutropenia are mainly performed in secondary or tertiary care.
The second study addressed the identification of risk factors and the development of a risk prediction model for FN in a hospital-based breast cancer cohort. Risk factors for FN were lower platelet count and haemoglobin, higher alanine aminotransferase (ALT), and specific allele variants of two single nucleotide polymorphisms (SNPs) in a gene involved in multidrug resistance. Genetic testing beforehand might be helpful to identify patients at a very high risk of FN. Predictive performance of the model was improved by adding genetic information but overall remained limited.
The third study used an available risk prediction model for FN in Non-Hodgkin lymphoma (NHL) patients and applied its prediction rules to an independent dataset of NHL patients. Age, weight, baseline white blood cell count, and planned chemotherapy dose were confirmed to predict the risk of FN. However, there was a decrease of the predictive performance in the independent validation dataset. This limits its use in clinical practice. But if successful risk prediction models are developed and externally validated, these may help to optimally target prophylaxis with G-CSFs to those patients at high risk of FN.
Finally, a systematic literature review was conducted to identify studies evaluating the efficacy, effectiveness and safety of G-CSFs in the prevention of CIN and FN. Most studies showed better efficacy and effectiveness for the long-acting pegfilgrastim than daily filgrastim. Efficacy and safety profiles of new long-acting G-CSFs such as lipegfilgrastim and balugrastim were comparable to pegfilgrastim. In times of increasing health care costs and scarce resources, the cost-efficient use of supportive measures is necessary.
The studies this work is based on showed that the availability of and access to appropriate data sources are necessary to develop and systematically validate risk prediction models. The findings contribute to the development of an evidence-based, efficient and cost-efficient approach to prevent neutropenia in cancer patients
Blind insight : a thesis presented in partial fulfillment of the requirements for the degree of Masters in Design at Massey University, Wellington, New Zealand
No full textThe loss of sight is usually associated with the loss of the visual outer world. Traditionally, total blindness
has been defined by sighted people in a negative way. The stereotypical belief is that the totally blind inhabit
a dark world in which mental images of the outer world no longer exist. However, gaining insight into an
experience of blindness may help the sighted to understand more accurately what Michael Monbeck (1973)
terms ‘the true meaning of blindness’. (Monbeck, 1973, p. 157)
Blind Insight provides an insight into what is named ‘imagined blind seeing’ by exploring the systematic
processes of sensing, selecting and perceiving.
Through tracing and mapping two auditory experiences photographically, the resulting work, Blind Insight,
seeks to give a visual voice to moments of perception and imagined images as described by the blind author
and scholar John Hull who describes sound as equating with light: “This is my way of turning on the light.
Sound is the equation to light. Rain has turned the light on.” (Hull, 2001, p. 10)
Abstract black and white photography has been employed to convey a sensory experience and photo collage
to make visible the dimensional complexity of imagined blind seeing.
The design work argues for a fresh insight into the sensory and imagined world of the blind. By fostering
a dialogue between the blind and the sighted, the research project aims at celebrating the many rich and
diverse ways the senses, and in particular the sense of sound, are used in experiencing the phenomena of
the physical world
Reward for Luck in a Dynamic Agency Model
No full textThis article studies a continuous time principal-agent problem of a firm whose cash flows are determined by the manager's unobserved effort. The firm's cash flows are further subject to persistent and publicly observable shocks that are beyond the manager's control. While standard contracting models predict that compensation should optimally filter out these shocks, empirical evidence suggests otherwise. In line with this evidence, our model predicts that the manager is "rewarded for luck." The Author 2010. Published by Oxford University Press on behalf of The Society for Financial Studies. All rights reserved. For Permissions, please e-mail: [email protected]., Oxford University Press.
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