564 research outputs found
World Environment Day: Beat Plastic Pollution
No full textEditorial Comment on World Environment Day by Dr. Sahil Thkar, Co-Editor, IHR
Tideglusib: The Miracle Molecule for Tooth Repair
No full textGuest Comment by Sahil Gupta titled "Tideglusib: The Miracle Molecule for Tooth Repair
Antibiotic Awareness Week: An Update
No full textAntibiotic Awareness Week: An Update Editorial Comment by Dr. Sahil Thakar, Co-Editor, IHR
Time to be Alert!! Stay Safe from the Omicron Variant of COVID-19
No full textEditorial Comment By Dr. Sahil Thakar on Behalf of the Editorial Board, IHR
World Mental Health Day 2020: Stress Levels at it Peak during Pandemic Times?
No full textEditorial Comment By Dr. Sahil Thakar, Co-Editor, IHRJ, and Assistant Professor, Department of Public Health Dentistry, School of Dental Sciences, Sharda University, Greater Noida
The Political Economy of the Corporation: Sahil Jai Duta Interviews Sandy Brian Hager
No full textPERC’s Sahil Jai Dutta is joined by Dr Sandy Brian Hager (City, University of London) to discuss the political economy of the corporation. He is the author of the book Public Debt, Inequality, and Power: The Making of a Modern Debt State (2016) published by University of California Press. The conversation spans across the topics of ownership and the politics of public debt, the power of large banks in the US, and his most recent work exploring what drives long-term shifts in the stock markets in the ‘advanced’ economies
The Political Economy of the Corporation: Sahil Jai Duta Interviews Sandy Brian Hager
No full textPERC’s Sahil Jai Dutta is joined by Dr Sandy Brian Hager (City, University of London) to discuss the political economy of the corporation. He is the author of the book Public Debt, Inequality, and Power: The Making of a Modern Debt State (2016) published by University of California Press. The conversation spans across the topics of ownership and the politics of public debt, the power of large banks in the US, and his most recent work exploring what drives long-term shifts in the stock markets in the ‘advanced’ economies
Local meridional circulation changes contribute to a projected slowdown of the Indian Ocean Walker circulation
No full textThe weakening of zonal atmospheric circulation, a widely accepted projection of climate change in response to global warming, features a weakening of the Indian Ocean Walker circulation (IWC), with an anomalous ascending motion over the western and anomalous descending motion over the eastern Indian Ocean. The projected IWC weakening has previously been attributed to slower warming in the east than the west, that is, to a positive Indian Ocean Dipole (10D)-like warming pattern. However, such a warming pattern can also be induced by IWC weakening. As a result, the cause-and-effect relationship cannot be easily determined, and the projected change is poorly constrained and highly uncertain. Here, using a suite of coupled climate model simulations under a high-emission scenario, we find that the IWC slowdown is accompanied by not only a positive 10D-like warming pattern but also anomalous meridional circulation that is associated with anomalous descending motion over the eastern Indian Ocean. We further show that the anomalous local meridional circulation is closely linked to enhanced land-sea thermal contrast and is unlikely to result from the positive IOD-like warming pattern, suggesting that the IWC weakening is in part driven by the anomalous local meridional circulation. Our findings underscore the important role of local meridional circulation changes in modulating future IWC changes.11Nsciescopu
Impact of the Indo-Pacific Warm Pool on the Hadley, Walker, and Monsoon Circulations
No full textThe Indo-Pacific warm pool (IPWP) is enclosed by a 28 degrees C isotherm and plays a vital role in controlling atmospheric circulations. However, the effects of changes in regional warm pool sea surface temperatures (SSTs) remain unexplored. We divided the IPWP into the Indian and Pacific sectors and distinguished their responses to natural variability and global warming. Furthermore, we examined the impacts of the interannual variability (IAV) in warm pool SST on the tropical Hadley, Walker, and monsoon circulations. The Hadley circulation was affected by warm pool SST warming, i.e., warmer SSTs over the warm pool strengthened the upward branch of Hadley circulation, whereas the downward branch was respectively weakened and strengthened in the Northern and Southern Hemispheres. Walker circulation was strengthened (weakened) in the warming (natural) mode. Consequently, the Walker circulation is weakened since the natural variability of warm pool SST plays a more dominant role rather than the warming trend of SSTs over the warm pool. Furthermore, our analysis displays that warm pool warming has little impact on the monsoon circulation. Our findings highlight the different roles of the IAV of warm pool regions in each tropical circulation as part of the warming trend and natural variability.11Nsciescopu
N-Glycosylation as a Modulator of Protein Conformation and Assembly in Disease
No full textGlycosylation, a prevalent post-translational modification, plays a pivotal role in regulating intricate cellular processes by covalently attaching glycans to macromolecules. Dysregulated glycosylation is linked to a spectrum of diseases, encompassing cancer, neurodegenerative disorders, congenital disorders, infections, and inflammation. This review delves into the intricate interplay between glycosylation and protein conformation, with a specific focus on the profound impact of N-glycans on the selection of distinct protein conformations characterized by distinct interactomes—namely, protein assemblies—under normal and pathological conditions across various diseases. We begin by examining the spike protein of the SARS virus, illustrating how N-glycans regulate the infectivity of pathogenic agents. Subsequently, we utilize the prion protein and the chaperone glucose-regulated protein 94 as examples, exploring instances where N-glycosylation transforms physiological protein structures into disease-associated forms. Unraveling these connections provides valuable insights into potential therapeutic avenues and a deeper comprehension of the molecular intricacies that underlie disease conditions. This exploration of glycosylation’s influence on protein conformation effectively bridges the gap between the glycome and disease, offering a comprehensive perspective on the therapeutic implications of targeting conformational mutants and their pathologic assemblies in various diseases. The goal is to unravel the nuances of these post-translational modifications, shedding light on how they contribute to the intricate interplay between protein conformation, assembly, and disease
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