1,721,075 research outputs found
The Blue Jackal
No full textHow surprising that I lived in Berkeley for four years and never ran across this book or this publisher while I was there! A Google search shows that Vidya Books still exists in Berkeley, though apparently with a post office box number, not a street address. This twenty-two page large-format children's book often combines text and colored illustrations on its paired pages. Sharma narrates the traditional story as an expanded fable, with pleasing development of the situation (drought and heat), scene (a small village near the jungle), and time of day (siesta). About the middle of the story, a "has" needs to be a "had" in the phrase "He has finished dyeing a load of muslin blue that morning." Perhaps the strongest illustration in the book is that of the blue jackal after he emerges from the tub. This same illustration is used on the book's dust-jacket and cover. In this telling, the jackal goes too far when he tells the other animals "Lord Krishna has made me blue in his image. He has also given me some of his special powers." This version then nicely brings the story to its climax with the long-awaited monsoon rains, which of course wash off the jackal's blue dye. "The free ride was over." When the other animals pursue the fleeing jackal, he lets out the "yowl" that is the usual give-away as to his true identity. There is an afterword on Punchtuntra stories. To my surprise, Sharma dates Dabshalim to the fourth century BCE; she says that Dabshalim "defeated the Greek Governor left behind by Alexander." There is also this statement to consider: "Some scholars connect these tales to the African Aesop…." She comments pointedly on the meaning of this story: "The story of The Blue Jackal is told in India to instill the idea of a color-blind society, as opposed to superiority of one race based on skin color." I had previously found a discontinued library copy of this book. This copy is in pristine condition and stays in the collection, while the other joins the "extras" collection.How surprising that I lived in Berkeley for four years and never ran across this book or this publisher while I was there! A Google search shows that Vidya Books still exists in Berkeley, though apparently with a post office box number, not a street address. This twenty-two page large-format children's book often combines text and colored illustrations on its paired pages. Sharma narrates the traditional story as an expanded fable, with pleasing development of the situation (drought and heat), scene (a small village near the jungle), and time of day (siesta). About the middle of the story, a "has" needs to be a "had" in the phrase "He has finished dyeing a load of muslin blue that morning." Perhaps the strongest illustration in the book is that of the blue jackal after he emerges from the tub. This same illustration is used on the book's dust-jacket and cover. In this telling, the jackal goes too far when he tells the other animals "Lord Krishna has made me blue in his image. He has also given me some of his special powers." This version then nicely brings the story to its climax with the long-awaited monsoon rains, which of course wash off the jackal's blue dye. "The free ride was over." When the other animals pursue the fleeing jackal, he lets out the "yowl" that is the usual give-away as to his true identity. There is an afterword on Punchtuntra stories. To my surprise, Sharma dates Dabshalim to the fourth century BCE; she says that Dabshalim "defeated the Greek Governor left behind by Alexander." There is also this statement to consider: "Some scholars connect these tales to the African Aesop…." She comments pointedly on the meaning of this story: "The story of The Blue Jackal is told in India to instill the idea of a color-blind society, as opposed to superiority of one race based on skin color." I had previously found a discontinued library copy of this book. This copy is in pristine condition and stays in the collection, while the other joins the "extras" collection.This is a hardbound book (hard cover)This book has a dust jacket (book cover)Written and illustrated by Rashmi SharmaWritten and illustrated by Rashmi Sharm
The small-scale approach in wastewater treatment
Get PDFThe wastewater treatment is an essential practice and is one of the forefront new
worldwide challenges. Indeed, the today aims in wastewater management are profoundly
changing. The sanitization processes are of course essential, but now some more efforts are
required not only to reduce the environmental impact of the effluent regarding the
receiving water body, for example in terms of organic load, but also to provide
management practices to allow water recovery, recycle and reuse. This means that treated
wastewater are new resources that may be reused according to their final level of quality.
New technological facilities are available about, some more are expected in the near future,
and innovative scaling approaches are strongly encouraged too. Actually, sometimes
extensive sewage collection systems are no more cost-effective, thus decentralisation
treatment processes considering small-scale wastewater treatment plants may represent a
potential solution in both developed and developing countries. Furthermore, this kind of
approach will strengthen those areas that are historically affected by drought phenomena or
are expected to suffer from water scarcities in the near future as a consequence of climate
change
A nanny model for intrinsically disordered proteins
Get PDFProteins without a well-defined tertiary structure are intrinsically unstable and are prone to degradation by the 20S proteasome. In my thesis, I investigate the protection mechanisms of intrinsically disordered (ID) protein regions via protein interactions using the AP-1 complex as a model system. AP-1 is composed of c-Fos and c-Jun proteins, out of which c-Fos has a shorter half-life than c-Jun. Interactions by c-Jun were shown to prolong the lifetime of c-Fos, leading to the proposal of the nanny model. This mechanism, where weak protein interactions protect unstructured regions without an induced folding, however, has never been probed directly.
Here I investigate the nature of the interactions of c-Fos with c-Jun and how changes in disordered regions contribute to changes in half-life. I use mutational analysis to provide insight into changes in degradation rate as a function of the binding affinity in the bound form with c-Jun. I designed five mutants at the structured regions of c-Fos affecting specific contact sites (L165V, L172V) or charge separation (E175D, E189D, K190R) with c-Jun of which both modulate c-Fos turnover, proportionally to their impact on binding affinity. Interestingly, removal of the disordered region in the complex beyond the structured domain is observed to decrease c-Fos half-life indicating their role in the stability of the complex. The finding suggests that the protein turnover by the 20S proteasome can be fine-tuned by both structured and unstructured regions between c-Fos and c-Jun, consistent with the proposed 'nanny' model.
These results highlight a novel aspect of disordered regions present in the bound form (fuzziness) in regulating protein half-life via fine-tuning the association rates between the two proteins. First, it demonstrates that the protection of disordered regions from degradation could be achieved without inducing a stable structure as confirmed by ECD spectroscopy. Binding to a partner generates a fuzzy complex, where fuzzy regions in protein complexes can serve as a nonspecific transient anchor. Second, the protection of disordered regions can be achieved with many binding configurations in the bound state without decreasing the conformational entropy. Thus, the protective role of fuzzy interactions from the 20S proteasome could also provide a possible explanation for how low-complexity sequence motifs involved in higher-order protein structures might serve as selective inhibitors of proteolysis.d
IMPORTANCE OF VAYASTHAPANA-MAHAKASHAYA DRUGS WSR TO ITS POTENTIAL USES IN GERIATRIC CARE
No full textSatyapal Sharma*, Rashmi Sharma and Sudipt Kumar Rat
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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