1,720,957 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Inhibition of Oxidation-Induced Misfolding of Mutant SOD1 in ALS using Small Molecules
Full text linkAbstract
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the loss of motor neurons resulting in progressive paralysis that eventually leads to the death of an afflicted individual. In a majority of ALS cases, the cause of onset is unknown, but a small subset of ALS cases are linked to mutations in the protein Cu, Zn superoxide dismutase (SOD1). Despite extensive research in this area, few treatments for ALS have been developed. Since the description of the disease by Jean-Martin Charcot in the mid-nineteenth century, only one drug, Riluzole has been approved in the management of this disease.
We propose investigating therapeutic treatments of ALS by looking for small molecules that have the potential to stabilize the native structure of mutant SOD1 and prevent its misfolding and aggregation. We started our investigation by first devising a method to optimize the purification of wildtype and mutant SOD1 in our lab. We constructed a fusion protein of SOD1 linked to a yellow fluorescent protein, a hexahistidine tag, and a tobacco etch virus (TEV) cleavage site and showed that both wildtype and mutant SOD1 purified from this construct was active and metallated.
We used our purified protein to explore the results of an in silico binding screen searching for SOD1 native-state binders. We discovered the flavonoid, epigallocatecin-3-gallate (EGCG) was able to inhibit the misfolding and aggregation of the ALS-causing mutation A4V-SOD1 exposed to oxidative stress. Additionally, we have evidence that the inhibitory effect of EGCG occurs through the stabilization of the dimer interface of mutant SOD1, rather than the anti-oxidant properties of this molecule. This is the first report of EGCG having anti-aggregation properties in an ALS model and these results implicate the potential therapeutic value of EGCG within the field of SOD1-ALS.Ph.D
Inhibition of Oxidation-Induced Misfolding of Mutant SOD1 in ALS using Small Molecules
No full textAbstract
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the loss of motor neurons resulting in progressive paralysis that eventually leads to the death of an afflicted individual. In a majority of ALS cases, the cause of onset is unknown, but a small subset of ALS cases are linked to mutations in the protein Cu, Zn superoxide dismutase (SOD1). Despite extensive research in this area, few treatments for ALS have been developed. Since the description of the disease by Jean-Martin Charcot in the mid-nineteenth century, only one drug, Riluzole has been approved in the management of this disease.
We propose investigating therapeutic treatments of ALS by looking for small molecules that have the potential to stabilize the native structure of mutant SOD1 and prevent its misfolding and aggregation. We started our investigation by first devising a method to optimize the purification of wildtype and mutant SOD1 in our lab. We constructed a fusion protein of SOD1 linked to a yellow fluorescent protein, a hexahistidine tag, and a tobacco etch virus (TEV) cleavage site and showed that both wildtype and mutant SOD1 purified from this construct was active and metallated.
We used our purified protein to explore the results of an in silico binding screen searching for SOD1 native-state binders. We discovered the flavonoid, epigallocatecin-3-gallate (EGCG) was able to inhibit the misfolding and aggregation of the ALS-causing mutation A4V-SOD1 exposed to oxidative stress. Additionally, we have evidence that the inhibitory effect of EGCG occurs through the stabilization of the dimer interface of mutant SOD1, rather than the anti-oxidant properties of this molecule. This is the first report of EGCG having anti-aggregation properties in an ALS model and these results implicate the potential therapeutic value of EGCG within the field of SOD1-ALS.Ph.D
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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