1,720,984 research outputs found
Effects of Plant and Animal Natural Products on Mitophagy
No full textMitophagy is a protected cellular process that is essential for autophagic removal of damaged mitochondria and for preservation of a healthy mitochondrial population. In the last years, a particular interest has been devoted in studying the effects of natural compounds on mitophagy. Different natural compounds may modulate mitochondrial oxidative phosphorylation, the production of mitochondrial reactive oxygen species, the expression of mitophagy- and autophagy-related genes, and the activities of transcription factors which regulate the expression of mitochondrial proteins, thereby controlling mitochondrial damage and mitophagy. Remarkably, since mitochondrial function has a crucial role in the pathogenesis of various diseases (e.g., cancer, atherosclerosis, Duchenne muscular dystrophy, diabetes complications, Alzheimer's disease, and hepatic steatosis), these effects might have important therapeutic implications. In this review, preclinical studies investigating the role of different natural compounds in the modulation of mitophagy will be discussed
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Eight New Sulfur Coordination Compounds Based on Group 12 Metal Ions with Variable Structures and Extraordinary Capacity for Iodine Adsorption: Synthesis, Structural Characterizations, and Density Functional Theory Calculations
No full textEight new sulfur-based coordination compounds ranging from 0D to 2D have been designed and synthesized. These compounds were created using bidentate flexible ligands based on methimazole with varying spacers of 2, 3, or 5 methylene groups (termed L2, L3, and L5). These compounds include [ZnBr2(L3)2]n (1), [Zn2Cl2(μ2-L3)(μ-L3)2(PF6)2] (2), [Cd2(N3)2(μ2-N3)2(μ2-L3)2] (3), [CdCl2(μ-L3)] (4), [CdCl2(L2)2]n (5), [CdBr2(L2)2]n (6), [HgBr2(L2)2]n (7), and {[Hg(L5)4]}n[ClO4]n (8), where Ln = 1, n-bis(1-methyl imidazole-2-thione)alkane. In the case of 1D polymers 1, 5, 6, and 7 with bridging bidentate ligands, the halides have not contributed to the expansion of the structures. In the centrosymmetric dimeric compound 2, with terminal chlorine groups, one of the ligands bridging two Zn(II) ions, while the other two display a chelating coordination mode. In the dimeric species of 3, the Cd(II) ions are connected by two bridging azides, while the remaining coordination sites of five-coordinate metal ions are satisfied by a chelating mode of the ligand and a terminal azide group, preventing the expansion of the structure. In the monomeric structure of 4, neither the ligand nor the halides are in their bridging mode. The longer spacer length of the ligand in 8 and the use of uncoordinated ClO4- anions lead to the formation of a 2D sulfur-rich structure with hca topology. These compounds were examined for their ability to adsorb iodine in both the vapor and solution phases. The maximum iodine uptake capacity in the solution ranged from 196.72 to 801.33 mg/g, setting an incredible record for such nonporous adsorbents. The effects of azide and chlorine on the geometry, electronic structures, and iodine adsorption capacity of complexes 3 and 4 were studied by using density functional theory (DFT) at the B3LYP/6-31G(d,p)/LANL2DZ level in both gas and solvent. These results were then compared with experimental data
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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