1,720,956 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Formulation and In-Vitro Evaluation of Lemborexant Orodispersible Film
No full textThe current work focused on the formulation and in vitro evaluation of Lemborexant oral dispersible films (ODFs) loaded with nanoparticles to improve solubility, dissolution, and patient compliance in the treatment of insomnia. Lemborexant, a dual orexin receptor antagonist, has low water solubility, reducing its oral bioavailability. To overcome this limitation, nanoparticles were prepared using the solvent displacement method and incorporated into fast-dissolving polymeric films that contained hydroxypropyl methylcellulose (HPMC) and carboxymethyl cellulose (CMC) as film-forming agents, PEG as a plasticizer, and superdisintegrants for rapid disintegration. The produced films were tested for physicochemical and mechanical properties such as thickness, weight fluctuation, folding endurance, tensile strength, surface pH, drug content homogeneity, disintegration time, and in vitro drug release.The optimized formulation demonstrated uniform thickness and weight, as well as appropriate tensile strength. The films disintegrated quickly (15-30 seconds) and had considerably higher in vitro drug release than pure Lemborexant. FTIR tests verified the absence of drug-excipient interactions, while SEM revealed homogeneous nanoparticle dispersion. The findings suggested that Lemborexant-loaded nanoparticle oral dispersible films are a viable delivery platform for quick onset of action, increased bioavailability, and enhanced patient compliance, particularly in geriatric patients with swallowing issues. Additional in vivo investigations are needed to confirm the therapeutic efficacy and pharmacokinetic advantages of the proposed formulation.
Keywords: Lemborexant, Oral Dispersible Film, Nanoparticles, Solvent Casting, In vitro drug release studies
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Formulation and Evaluation of Mucoadhesive Bilayered Buccal Tablet of Ziprasidone Hydrochloride
Get PDFThe present project was carried out to formulate and evaluate the mucoadhesive bilayered buccal tablet of Ziprasidone Hcl. Ziprasidone HCl is an antipsychotic agent with half-life of about 2hrs and shows extensive metabolism i.e the drug concentration is < 5% after elimination in the body. The formulations (F1 to F6) were developed which comprises of polymers such as Hydroxypropyl methyl cellulose (HPMC K-15), Polyvinyl pyrollidine (PVP K-30) in various concentrations along with carbopol to achieve the desired characteristics. Mucoadhesive bilayered buccal tablets were fabricated with the aid of direct compression technique and the prepared formulation was evaluated for its physicochemical parameters along with evalauation test. The results from different evaluation test demonstrated that the formulation F1 containing HPMC (25 mg) and CP (10 mg) was selected as optimised formulation and result values of precompression parameters were within the limits and post compression results showed the mucoadhesive strength of F1 formulation was 25.27gm, the drug release at 8th hr was 85.7 % and the formulation was stable throughout the stability studies. Hence mucoadhesive bilayered buccal tablets of Ziprasidone HCl can be prepared. Based on the above results it can be stated that mucoadhesive bilayered buccal tablets can be successfully developed. Formulation described that the nature of tablet depends not only on the se lected polymer excipient but also on the concentration of polymers selected.
Keywords: Ziprasidone HCl, Bilayered Buccal Tablet, Mucoadhesion.  
Formulation and evaluation of Lamivudine transferosomal gel
Get PDFAim and objective: The aim of the study was to formulate and evaluate Transferosomal gel of lamivudine.
Method:Lamivudine transferosomes was prepared using thin film hydration method taking span 80, Polyoxyethylene lauryl ether in different proportion. the formulation was characterised by UV spectroscopy, FTIR, in-vitro drug release, gel evaluations.
Results: Total nine formulations were formulated and optimised formulation F3 showed entrapment efficiency EE (91.17), %CDR (96.12) and small particle size (98.19 nm). SEM of optimized lamivudine Transferosomes appeared as spherical, well identified, unilamellar vesicles. The optimized formulation of Transferosomes was further formulated to gel with Poloxamer 407 gel 0.5%, 1% and 2% w/w ,HPMC k15, Propylene glycol, DMSO. Among these F3 formulation with Poloxamer 407 2%w/w transferosomal gel is the optimised transferosmal gel and showed Spreadability value 6.01±0.12 cm, pH value 5.01 ±0.47. The actual drug content of the Transferosomal gel was found to be 97.29 ±0.66%, which represents good content uniformity. The viscosity of lamivudine Transferosomal gel is found to 5960 ±0.75cps. The percentage drug release for lamivudine Transferosomal gel is 97.31 %. stability studies showed that Transferosomal gel is more stable at 4˚C when compared to other temperatures. The future scope of the study is to perform the In Vivo studies to evaluate the potency of the prepared formulation.
Keywords: Lamivudine Transferosomal gel, Transferosomes, Topical, Anti-viral drug, Thin Film Hydration Technique
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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