75 research outputs found
Evaluation of cellobiose dehydrogenase and laccase containing culture fluids of Termitomyces sp. OE147 for degradation of Reactive blue 21
No full textAbstractThis study evaluates culture filtrate, rich in cellobiose dehydrogenase and laccases, of Termitomyces sp. OE 147, in decolouration and degradation of Reactive blue (RB) 21. About 35% decolouration was achieved at low volumes of the culture supernatant without addition of external redox mediators. An optimized dye to culture fluid ratio (75ppm: 0.1ml) at a pH of 4–5 resulted in removal of colour by 60%. The degradation products of RB21 were analysed by Electron Spray Ionization-Mass Spectrometry and several small molecules (ofm/z 106–199) were detected. These were concluded to be o-Xylene, 2,3-Dihydro-1H-isoindole, Isoindole-1,3-dione, 2,Benzenesulfonyl-ethanol, (4-Hydroxy-phenyl)-sulfamic acid, 2,3-Dihydro-1H-isoindole-5-sulfonic acid and proposed to result from joint action of cellobiose dehydrogenase, laccase, peroxidases and unidentified oxidoreductases present in the culture fluids. Based on the products formed and the known reactions of these enzymes, a degradation pathway was proposed for RB21. The culture fluid was also effective in decolouration (by about 50%) and detoxification (by ∼25%) of the combined effluent collected from a local mill indicating a treatment process that bypasses use of H2O2 and toxic mediators
اجتہاد الرسول ﷺ از نادیہ شریف العمری کا تعارفی مطالعہ: An Introductory Study of Ijtihad Al-Rasool ﷺ by Nadia Sharif Al-Omari
No full textThe biography of the Prophet ﷺ is a subject that has been extensively written about since the first century of Hijra, continues to be written about today, and will undoubtedly remain a topic of scholarly and devotional interest in the future. This subject holds religious, academic, historical, and contemporary significance, prompting Muslim scholars of every era to contribute to its exploration. Alongside men, women have also engaged in writing on this subject to express their devotion and love for the Prophet ﷺ. From ancient to modern times, women have played their part in this field, and while their contributions are fewer in comparison to men, their numbers are steadily increasing in modern times. Women have also explored various aspects of the Prophet's ﷺ biography in the Arabic language. One notable work in this context is "Ijtihad Al-Rasool" authored by Nadia Sharif Al-Omari. This book uniquely combines the principles of Islamic jurisprudence (Usul al-Fiqh) with the life of the Prophet ﷺ, analyzing whether the Prophet ﷺ engaged in ijtihad (independent reasoning). The author meticulously presents evidence supporting her conclusion that the Prophet ﷺ did indeed engage in ijtihad. This article provides a research-based and analytical study of her book. It begins by discussing the biographical details of the author, followed by an introduction to the book. Subsequently, the writing style of the author and the nuanced insights within her work are critically examined. Finally, the findings and recommendations of the study are presented.
Fatigue of woven thermoplastic composites: The effect of the fibre-matrix interface
No full textSI&CAerospace Engineerin
GUI implementation of image encryption and decryption using Open CV-Python script on secured TFTP protocol
No full textPrevention and potential remedies for antibiotic resistance: current research and future prospects
No full textThe increasing threat of antibiotic resistance and shrinking treatment options for infections have pushed mankind into a difficult position. The looming threat of the return of the pre-antibiotic era has caused a sense of urgency to protect and conserve the potency of antibiotic therapy. One of the perverse effects of antibiotic resistance is the dissemination of its causative agents from non-clinically important strains to clinically important strains and vice versa. The popular saying “Prevention is better than cure” is appropriate for tackling antibiotic resistance. On the one hand, new and effective antibiotics are required; on the other hand, better measures for the use of antibiotics, along with increased awareness in the general public related to antibiotic use, are essential. Awareness, especially of appropriate antibiotic use, antibiotic resistance, its dissemination, and potential threats, can help greatly in controlling the use and abuse of antibiotics, and the containment of antibiotic resistance. Antibiotic drugs’ effectiveness can be enhanced by producing novel antibiotic analogs or adding adjuvants to current antibiotics. Combinatorial therapy of antibiotics has proven successful in treating multidrug-resistant (MDR) bacterial infections. This review aims to highlight the current global situation of antibiotic resistance and discuss the methods used to monitor, prevent, inhibit, or reverse bacterial resistance mechanisms in the fight against antibiotic resistance
Coaching 5.0, coaching for the fifth industrial revolution
No full textThe rising use of Artificial Intelligence (AI), Metaverse and Blockchain technologies has influenced capabilities in a wide variety of industries. These have now started to provide affordances for automating provision of insight and empowerment in coaching business leaders and staff. This paper discusses the risk, that as such technologies become smarter, human beings may abdicate their thinking capabilities, especially related to creative problem solving, to machine intelligence. The author calls for prevention of cognitive decline in human beings as machines get smarter. A route to this can be mapped through use of Industry 5.0, Fifth Industrial Revolution (5IR) approaches, that focus on a harmonisation of human and machine intelligence, ensuring human beings can make machines smarter and that machine intelligence can in turn make human consciousness advance. Practitioner Coaches, to future proof their practice, must ensure they embody 5IR mindsets, techniques and technologies. The coaching discipline that is fit for practice in 5IR environments and contexts is what the author has called “Coaching 5.0.” This paper looks at Coaching 5.0 components and how they can be adopted by coaches to ensure the future is sustainable, insightful and empowering one for their practice and for their clients
underlying autosomal recessive primary microcephaly in 32 consanguineous families from Pakistan
No full textAbstract Background Primary microcephaly (MCPH) is a congenital neurodevelopmental disorder manifesting as small brain and intellectual disability. It underlies isolated reduction of the cerebral cortex that is reminiscent of early hominids which makes it suitable model disease to study the hominin‐specific volumetric expansion of brain. Mutations in 25 genes have been reported to cause this disorder. Although majority of these genes were discovered in the Pakistani population, still a significant proportion of these families remains uninvestigated. Methods We studied a cohort of 32 MCPH families from different regions of Pakistan. For disease gene identification, genome‐wide linkage analysis, Sanger sequencing, gene panel, and whole‐exome sequencing were performed. Results By employing these techniques individually or in combination, we were able to discern relevant disease‐causing DNA variants. Collectively, 15 novel mutations were observed in five different MCPH genes; ASPM (10), WDR62 (1), CDK5RAP2 (1), STIL (2), and CEP135 (1). In addition, 16 known mutations were also verified. We reviewed the literature and documented the published mutations in six MCPH genes. Intriguingly, our cohort also revealed a recurrent mutation, c.7782_7783delGA;p.(Lys2595Serfs*6), of ASPM reported worldwide. Drawing from this collective data, we propose two founder mutations, ASPM:c.9557C>G;p.(Ser3186*) and CENPJ:c.18delC;p.(Ser7Profs*2), in the Pakistani population. Conclusions We discovered novel DNA variants, impairing the function of genes indispensable to build a proper functioning brain. Our study expands the mutational spectra of known MCPH genes and also provides supporting evidence to the pathogenicity of previously reported mutations. These novel DNA variants will be helpful for the clinicians and geneticists for establishing reliable diagnostic strategies for MCPH families
تصوف کے سلسلہ ’’امینیہ‘‘ کی علمبردار ’معراج العاشقین‘ کی اولین ترتیب و اشاعت
No full text“Miraj-ul-Aashiqeen” was frist published by Maulvi Abdul Haq with muqadmma and Farhang from Hyderabad Deccan in 1343 Hijri. The subject of "Miraj-ul-Aashiqeen" is Sufism, whose poles go to the "Amina Family" and whose founder is Syed Shah Amin-ud-Din Alla. In the light of modern research, researchers are divided into two groups regarding the author of "Miraj-ul-Aashiqeen" and the first motivator of this difference of opinion is the Muqadamma of Maulvi Abdul Haq, written for "Miraj-ul-Aashiqeen". This book is of special importance in the history of Urdu literature due to its subject 'Sufism' and the orthodoxy of its language
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