86,526 research outputs found
Influence of coniugated oestrogens on circulating oestradiol, oestrone, LH, FSH and prolactin levels in postmenopausal women
No full textThe effects on plasma 17-β-oestradiol (E 2), oestrone (E 1), LH, FSH and prolactin (PRL) levels of 1.5 mg conjugated oestrogen, administered daily per os for 20 consecutive days, was investigated in six postmenopausal women aged 60-68. Both E 2 and E 1 increased progressively and significantly (p0.05). LH and FSH decreased progressively and significantly (pp>0.02) was observed for plasma PRL during and after oestrogen administration. Such results indicate that in postmenopausal women the specific enzymatic mechanism of oestrogen interconversion is maintained and that there is no increase of prolactin. In this way, the possible effects on the development of breast cancer by elevated levels of this hormone, usually observed during long-term oestrogen therapy, would be avoided
Effetti della iperprolattinemia indotta con sulpiride sulla secrezione di testosterone dopo HCG e sulla attivita' aromatizzante e 5-alfareduttasica in soggetti adulti e normali.
No full textNanoscale Viscoelastic Behavior of the Surface of Thick Polystyrene Films as a Function of Temperature
No full textThe variation in the glass transition temperature of thin polymeric films represents a phenomenon yet to be fully explained. To date, it is widely agreed that it is linked to the interfaces that the film forms with the air and the supporting substrate. Herein, we address one of the main issues regarding the viscoelastic behavior of the region near the free interface of thick polystyrene films where a reduction in the glass transition temperature is expected to occur. We have measured, as a function of the temperature, the elastic and viscous responses of polystyrene films with molecular weights above and below the critical value for the occurrence of molecular entanglement. The experiments have been carried out by means of scanning probe microscopy in a configuration combining the acquisition of force versus distance and indentation versus time curves. We show that the viscoelastic behavior of polystyrene films with thickness down to 30 nm can be successfully evaluated in the time scale from tenths to tens of seconds. In particular, we observe that the viscoelastic behavior of thick film surfaces has a similar dependence from the temperature as the viscoelastic behavior of the bulk, independently if the molecular weight is above or below the critical value. We estimate that the region at the free interface with a reduced glass transition temperature, if present, has a thickness below 3 nm
Applicability of salivary testosterore measurements for the follow-up of therapy of idiopathic hirsutism
No full textVariations on the Author
No full text“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
[Newspaper Clipping: Author Claims Evidence of Second JFK Assassin #1]
No full textNewspaper article titled "Author Claims Evidence of Second JFK Assassin." The article states that author Richard J. Whalen concluded "that there is circumstantial evidence to support the theory of a second assassin in the shooting of President John F. Kennedy.
Also By The Same Author: AKTiveAuthor, a Citation Graph Approach to Name Disambiguation
No full textThe desire for definitive data and the semantic web drive for inference over heterogeneous data sources requires co-reference resolution to be performed on those data. In particular, name disambiguation is required to allow accurate publication lists, citation counts and impact measures to be determined. This paper describes a graph-based approach to author disambiguation on large-scale citation networks. Using self-citation, co-authorship and document source analyses, AKTiveAuthor clusters papers, achieving precision of 0.997 and recall of 0.818 over a test group of eight surname clusters
John F. Kennedy telegram to Roosevelt
No full textJersey Homesteads (later the Borough of Roosevelt) was established in the 1930s as an agro-industrial cooperative community. It was established specifically for urban Jewish garment workers, many of whom had emigrated from Europe. President John F. Kennedy sent a telegram to the citizens of Roosevelt, New Jersey, apologizing for not being able to attend the memorial dedication in honor of former President Franklin Delano Roosevelt. (Jersey Homesteads became Roosevelt in 1945 in honor of the president.) President Kennedy expressed his gratitude to the people of Roosevelt for constructing the memorial, and commented that it will serve as a constant reminder of Roosevelt's good works
Further data on beta-blockers and cancer. Observational study and meta-analysis of randomized clinical trials
No full textBackground: The aim of the present paper is to provide some further data on the relationship between β-blocker treatment and the incidence of cancer, using two different approaches (epidemiological study and meta-analysis of clinical trials). Methods: In a consecutive series of 1340 diabetic patients starting insulin therapy, 112 cases of cancer during a mean follow-up of 75.9 months were identified as first hospital admission or death. For each case, the controls were chosen randomly from those members of the cohort matched for age, sex and BMI. The main predefined analysis was the comparison of cases and controls for length of exposure to β-blockers and proportion of patients exposed using a conditional logistic regression which takes into account the matching structure. For the meta-analytic sub-study, an extensive search of Medline and the Cochrane Library (any date up to December 31st, 2011) was performed for all trials in which a β-blocker was used. Mantel-Haenszel Odds Ratios (MH-OR) with 95% confidence intervals for incident malignancies were calculated using a random effect model. Results: After adjusting for mean daily dose of glargine and metformin, and ischemic heart disease, exposure to β-blockers was associated with a reduced overall risk of cancer (HR 0.33 [0.13; 0.83], p = 0.019; HR for each month of exposure 0.87 [0.77; 0.98], p = 0.025). In the meta-analysis sub-study, performed on nine trials, β-blockers were associated with a non-significant trend toward lower risk of cancer (MH-OR 0.93 [0.86; 1.01], p = 0.070). Study limitation: Limitations of the observational study are the small sample size that limits the statistical power of analyses, that it was performed on diabetic patients only, and that diagnoses of malignancies were derived from administrative data. Conclusions: In conclusion, this research seem to confirm a possible beneficial effect of β-blockers against the risk of cancer development
Amplification of LH response to LHRH by dopamine infusion in eugonadal women
No full textAlthough the role of biogenic amines in the regulation of gonadotropin release has been studied extensively, the precise role of dopamine (DA) in stimulating LHRH and/or LH release is still controversial. In the present study 6 eugonadal women, aged 20-30, were given an LHRH infusion on day 6 of the menstrual cycle and the pattern and magnitude of LH and FSH responses were estimated. On day 6 of the next cycle, the experiment was repeated and DA was also infused beginning 60 min after the start of the LHRH infusion. Following LHRH infusion plasma LH showed a marked and significant rise with a mean peak increment at 4 h, and with a cumulative response (CR) of 9136 ± 955 mlU/ml/6h. The pattern of FSH response tended to parallel that of LH; however, mean peak increment at 4 h and a CR of 2640 ± 169 mlU/ml/6h were markedly lower. Plasma prolactin levels remained unchanged. Addition of DA to LHRH at 60 min evoked a significantly greater mean peak LH increment at 4 h and a CR of 15514 ± 1836 mlU/ml/6h (p<0.001). There were no significant changes in either mean FSH peak at 4 hr or in the CR (3257 ± 309 mlU/ml/6h). As expected, a highly significant (p<0.001) decrease in circulating PRL from 12.1 ± 3.1 to 3.0 ± 1.5 ng/ml was seen during DA infusion. In conclusion, DA given by iv infusion enhances LH response to LHRH in eugonadal women under the conditions of the present investigation, supporting a role for a dopaminergic component in the control of LH release in women
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