58 research outputs found
Performance of Information Complexity Criteria in Structural Equation Models with Applications
No full textA common problem in structural equation modeling is that of model selection. Many researchers have addressed this problem, but many methods have provided mixed benefits until recently. Akaike's well-known criteria, AIC, has been applied in the context of structural equation modeling, but the effectiveness of many other information criteria have not been studied in a convincing manner. In this paper, we compare the SEM model selection prowess of several AIC-type and ICOMP-type criteria. We also introduce two new large sample consistent forms of Bozdogan's ICOMP criteria - one of which is robust to model misspecification. To study the empirical performance of the information criteria, we use a well-known SEM simulation protocol, and demonstrate that most of the information-theoretic criteria select the pseudo true model with very high frequencies. We also demonstrate, however, that the performance of AIC is inversely related to the sample size. Finally, we apply the new criteria to select an analytical model for a real dataset from a retail marketing study of consumer behavior. Our results show the versatility of the new proposed method where both the goodness-of fit and the complexity of the model is taken into account in one criterion function.Scientific and Technological Research Council of Turkey (TUBITAK); Department of Statistics, Operations, and Management Science at the University of TennesseeThis research was supported by the Scientific and Technological Research Council of Turkey (TUBITAK) for the first author at the Department of Statistics, Operations, and Management Science at the University of Tennessee as a Visiting Scholar under the supervision of Professor Bozdogan. The first author extends her gratitude and thanks to Professor Bozdogan for the hospitality and conducive research atmosphere provided
A Rare Double Aneuploidy Case (Down-Klinefelter)
No full textWOS: 000415273800007PubMed ID: 29142768Down's syndrome has its own dysmorphic findings and is accompanied by mental retardation and hypotonia. Klinefelter's syndrome is a syndrome caused by a numerical abnormality that affects male physical and cognitive development. This case reports a unique finding of 48,XXY, + 21 and a current literature review. A 4-month-old male patient presented with typical clinical features of Down's syndrome with hypothyroidism, atrial septal defect, ventricular septal defect, and patent ductus arteriosus without any phenotypic signs of Klinefelter's syndrome
Clinical utility of of molecular karyotyping
No full textWOS: 000445937400007Purpose: The aim of this study was to investigate molecular karyotyping of epilepsy and intellectual disabilites and to reveal its relationship with these diseases. Materials and Methods: A total of 580 patients with a wide range of clinical problems underwent molecular karyotyping by Affymetrix CytoScan platform included in the study that were presented to Medical Genetics Policlinics of Balcali Hospital and Clinics, Cukurova University Faculty of Medicine. Results: Molecular karyotyping identified 41% microdeletions, 32% duplications and 50% both deletions and duplications in mental retardation patients; 16% microdeletion, 34% duplications and 50% both deletions and duplications in epilepsy patients; and 33.3% microdeletions, 44.4% duplications and 22.2% both deletions and duplications in mental retardation with epilepsy group. In addition, one of epilepsy group with uniparental disomy and 2 marker chromosomes were detected in this study. Conclusion: Our results demonstrate that molecular karyotyping and clinical interpretation by a medical geneticist is efficient in diagnosing chromosomal diseases. Moreover, molecular karyotyping might be more effective as a first tier testing in epilepsy and psychomotor retardation patients
Hereditary spastic paraplegia type 35 with a novel mutation in fatty acid 2-hydroxylase gene and literature review of the clinical features
No full textSupernumerary Nipple Children with Different Types of Malignancies
No full textA supernumerary nipple (SN), usually arises within the embryonic milk lines but can also occur in locations such as back, thigh, vulva and neck. The frequency of SN ranges from 0.2% to 5.6% depending on various factors. Although much has been written on the association of SN with other conditions, it still remains as a controversial and speculative area. SN can be associated with several disorders notably urological malformations and urogenital malignancies. To the our knowledge, the association of SN with childhood cancer has rarely been reported before. [Med-Science 2016; 5(1.000): 342-4
eNOS Gene Intron 4 VNTR and Exon 7-G894T Polymorphisms in Turkish Men with Erectile Dysfunction: A Case Control Study
No full textThe associations between the gene polymorphisms and erectile dysfunction (ED) are limited
A comparative study of polyphenol oxidase from two varieties of quince (Cydonia Oblonga)
No full textA comparative study of polyphenol oxidase (PPO) from two Turkish varieties of quince (Eşme and Kalecik) was conducted to determine some of the characteristics of the enzymes in terms of temperature and pH optima, substrate specificity, thermal inactivation and potency of some PPO inhibitors. PPO was partially purified by ammonium sulfate precipitation followed by dialysis. The optimum pH and temperature of the two PPOs were found to be similar. The apparent substrate specificity was established from V. max/K. m as 4-methylcatechol > catechol > pyrogallol for PPO from Eşme variety (PPOEşme). The substrate specificity for PPO from Kalecik variety (PPOKalecik) was catechol > 4-methylcatechol > pyrogallol. Heat stabilities and substrate specificities of the two enzymes differed. © 2010, The Author(s). Journal compilation © 2010, Wiley Periodicals, Inc
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