1,721,055 research outputs found
Ripartire dall'Osso. Nuovi turismi rigenerativi per i territori rurali di margine.
No full textIl tema del recupero dei patrimoni pubblici lungo linee di turismo lento come ciclovie o cammini è oggi sempre più rilevante e attuale. Prova ne sono le tante iniziative in Europa, ma anche alcune recenti esperienze italiane come il bando dell’Agenzia del Demanio del 2017, Valore Paese – Cammini e Percorsi. Parliamo di Turismi Sportivi Itineranti (TSI), ovvero trekking, cicloturismi e cammini. Si tratta di declinazioni turistiche di pratiche che hanno radici sportive, che attraversano territori vasti e che necessitano di servizi di accoglienza, supporto, assistenza. Nei territori rurali di margine, se i sentieri attrezzati fossero ripensati assieme ad opportuni servizi (oggi carenti), si potrebbero aprire nuovi scenari di sviluppo sostenibile e diffuso. Nell’ambito di influenza di questi sentieri si trovano edifici pubblici abbandonati o sottoutilizzati, che previo recupero architettonico e antisismico potrebbero ospitare servizi di accoglienza, e diventare laboratori di sperimentazione per l’implementazione di un modello occupazionale innovativo ed inclusivo. I sentieri vengono visti, dunque, come risorse strategiche per aiutare la ripresa della vita sociale ed economica nei territori rurali delle aree interne. Il contributo, a partire dallo studio di alcuni primi casi applicativi, riporta alcuni iniziali ragionamenti sul potenziale rigenerativo del TSI e su possibili forme attraverso le quali avviare servizi a supporto, non solo del TSI, ma anche della vita delle comunità locali
Ergothioneine oxidation protects against high-glucose induced endothelial senescence via SIRT1 and SIRT6
No full textSIRT1 and SIRT6 Signaling Pathways in Cardiovascular Disease Protection.
No full textSIGNIFICANCE:
Oxidative stress represents the common hallmark of pathological conditions associated with cardiovascular disease (CVD), including atherosclerosis, heart failure, hypertension, aging, diabetes, and other vascular system-related diseases. The sirtuin (SIRT) family, comprising seven proteins (SIRT1-SIRT7) sharing a highly conserved nicotinamide adenine dinucleotide (NAD+)-binding catalytic domain, attracted a great attention for the past few years as stress adaptor and epigenetic enzymes involved in the cellular events controlling aging-related disorder, cancer, and CVD. Recent Advances: Among sirtuins, SIRT1 and SIRT6 are the best characterized for their protective roles against inflammation, vascular aging, heart disease, and atherosclerotic plaque development. This latest role has been only recently unveiled for SIRT6. Of interest, in recent years, complex signaling networks controlled by SIRT1 and SIRT6 common to stress resistance, vascular aging, and CVD have emerged.
CRITICAL ISSUES:
We provide a comprehensive overview of recent developments on the molecular signaling pathways controlled by SIRT1 and SIRT6, two post-translational modifiers proven to be valuable tools to dampen inflammation and oxidative stress at the cardiovascular level.
FUTURE DIRECTIONS:
A deeper understanding of the epigenetic mechanisms through which SIRT1 and SIRT6 act in the signalings responsible for onset and development CVD is a prime scientific endeavor of the upcoming years. Multiple "omic" technologies will have widespread implications in understanding such mechanisms, speeding up the achievement of selective and efficient pharmacological modulation of sirtuins for future applications in the prevention and treatment of CVD. Antioxid. Redox Signal. 28, 711-732
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
European small towns: what role do they play in metropolitan governance?
Full text linkIn recent years, several studies have explored the challenges that accompany the creation of metropolitan governments, with particular reference to the institutional relations and power dynamics that potentially subordinate smaller towns to logics and objectives defined in the core area. This paper argues that the establishment of new governance arrangements exercising autonomous metropolitan political power may overcome the institutional fragmentation of metropolitan regions, but it may also overshadow the role played by the smaller towns, which often lack the opportunity or the necessary institutional capacity to participate in the process. The effectiveness of existing metropolitan settings from the small-town perspective is addressed comparatively in the contexts of England, France and Italy, three European countries that have experienced recent metropolitan reforms. The authors trace the history of the administrative reforms that have characterised the three countries, the spatiality of their metropolitan authorities, and the instruments and mechanisms that allow for the engagement and cooperation of small towns with(in) metropolitan authorities. They argue that the actual potential for the engagement of small towns within metropolitan governance dynamics is path- and context-dependent and often hampered by the institutional preconditions that gave birth to metropolitan governance in a specific context
National Overview - Italy
No full textESPON 2.3.2 "Governance of territorial and urban policies from EU to local level
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