1,721,229 research outputs found
The value of the calcium binding protein S100 in the management of patients with traumatic brain injury
No full textBackground: From the first study in 1995 the role of calcium-binding protein S100B in Traumat- ic Brain Injury (TBI) has been variously investigated in many clinical works. The aim of this work is to an- alyze the recent published reports with a reference to serum and CSF levels and to identify a possible role of S100 in the management of TBI. Methods: A MEDLINE search with a various number of query related to “S100” and “TBI” was performed from 2000 to 2011. All identified articles and abstracts have been re- viewed Results: Serum and CSF samples of the marker well correlate in most of the papers to the degree of intracranial injury as determined by CT scans. Furthermore patients with the higher levels of S100B show a worse prognosis. In the paediatric age a relationship with the outcomes in spite of difficulties to determine normal values is also observed. Some proposal about a clinical use of S100B to decrease the number of neu- roradiological examinations are present. Conclusions: S100B shows some interesting potentialities, but we have not enough evidence to insert this marker of brain damage in the protocols for management of TBI. However its use in experts’ hands in association with others clinical and radiological features may help to im- prove medical practice in the treatment of TBI
Decompressive Craniectomies: Time to Discuss not the Decra Study but the Comments to the Decra Study
No full textIn vivo and ex vivo magnetic resonance spectroscopy in the characterization of hemangioblastoma cyst fluid
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The current role of MMAE in chronic subdural hematomas: a real advantage? A critical analysis of the EMBOLIZE study
No full textNavigation-assisted microscopic removal of hypophyseal adenoma: a retrospective study
No full textNeuronavigation is a commonly used technology that provides continuous, three-dimensional information for the precise localization of and surgical trajectory to brain lesions. This study was performed to evaluate the role that navigation can play in assisting microsurgical trans-sphenoidal surgery for precise localization and removal of pituitary tumours while simultaneously preserving pituitary gland function. Six patients (3 males and 33 females)with hypophyseal adenomas were treated with neuronavigation-assisted removal. Surgery was performed via endonasal trans-sphenoidal approach. Three patients had residual adenomas and two of the relapsed. There was one post operative rhinoliquorrea. In two cases the visual deficit did not significantly improved after operation. No statistical significance was detected among tumor dimensions with residual tumor, surgical complication (i.e. rhinoliquorrea), persisting visual deficit and used of abdominal fat for closing the sphenoidal field, respectively.
Microneurosurgical trans-sphenoidal techniques combined with neuronavigation systems can precisely define
the localization and removal of lesions in the sella region with respect to the margins of important anatomical structures in the neighbourhood and the endocrinological functionality of the pituitary gland. Neuronavigation can be easy applied during endonasal trans-sphenoidal microscopic surgery and requires a minimal amount of time. It makes operation easier, faster, and probably safer
Descriptive epidemiology of head injury in Romagna and Trentino. Comparison between two geografically different italian regions.
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