196,608 research outputs found
Intelligenza artificiale e formazione in traduzione: nuove competenze per traduttori e revisori specialistici
No full textL’intelligenza artificiale e lo sviluppo delle nuove tecnologie hanno rivoluzionato inevitabilmente il ruolo e i compiti delle figure professionali operanti nel settore delle lingue, tra cui quelle del traduttore e del revisore specialistico, chiamati non solo a conoscere le lingue di lavoro, ma anche a padroneggiare l’utilizzo di strumenti tecnologici, alla gestione del processo traduttivo a quella delle diverse testualità e terminologie. Una formazione teorica in terminologia, unita a un saper fare pratico, costituisce un sicuro punto di forza in termini di professionalità e competitività.Artificial intelligence and the development of new technologies have inevitably revolutionised the role and tasks of language professionals, including specialist translators and proofreaders, who must not only master their working languages but also use technological tools, manage the translation process and manage the various textual and terminological aspects. Theoretical training in terminology, combined with practical know-how, is a definite asset in terms of professionalism and competitiveness.L'intelligence artificielle et le développement des nouvelles technologies ont révolutionné le rôle et les tâches des professionnels du secteur linguistique, y compris ceux du traducteur et du correcteur spécialisés, qui sont appelés non seulement à connaître les langues de travail, mais aussi à maîtriser l'utilisation des outils technologiques, la gestion du processus de traduction et la gestion des différents aspects textuels et terminologiques. Une formation théorique en terminologie, combinée à un savoir-faire pratique, constitue un atout certain en termes de professionnalisme et de compétitivité
MALATTIA DI ALZHEIMER E DEGENERAZIONE LOBARE FRONTOTEMPORALE: RICERCA DI MUTAZIONI AUTOSOMICHE DOMINANTI E ANALISI GENETICA E FUNZIONALE DI GENI CANDIDATI
No full textThis PhD study is intended to perform a genetic screening on a population of AD and FTLD patients in order to identify pathogenetic causal mutations (PSEN1, PSEN2 and APP for AD; MAPT, GRN and the GGGGCC repeat expansion one the C9orf72 gene for FTLD) and to investigate the role of several candidate genes (GRN,TMEM106b and OLR1) considered to be risk factors for the two disease.
Eighteen patients were carriers of pathogenetic causal mutations: 1 carrier of Ala260Val (g.49964C>T) situated in exon 8 of PSEN1,16 carriers of GRN gene mutations and 1 carrier of a new variant, Gly304Ser (g.123789G>A), located in exon 10 of MAPT gene. The presence of GGGGCC repeat expansion, positioned on the first intron of C9orf72 gene, was analyzed in a larger population (651 FTLD patients, 21 CBD and 31 PSP patients). Thirty nine patients with FTLD were carriers of pathogenetic repeat expansion, whereas none of CBD and PSP patients as well as 222 controls carried the mutation. Several associations studies were performed in the remaining sporadic population of AD and FTLD patients. Regarding the influence of GRN genetic variability on susceptibility to AD, two SNPs rs9897526G>A and rs5848 were investigated. A tendency to an increased frequency of rs5848T allele was found in AD patients as compared with controls, whereas for the rs9897526 SNP, in patients carrying the rs9897526A variant was observed a significant earlier age at disease onset compared with patients carrying the G allele. The case-control study carried out on a populations of FTLD patients was focused on four Tagging SNPs (rs2879096, rs3785817, rs4792938 and rs9897526) as well as on rs5848 SNP, localized in the 3’UTR of GRN gene. A statistically significant association of the rs4792938 CC genotype was observed in FTLD patients compared with healthy controls. Concerning the role of TMEM106b gene on susceptibility to AD, an association analysis was performed on three SNP, rs1020004 A/G, rs6966915 C/T and rs1990622 A/G, but no significant differences in allelic and genotype frequencies were found for all polymorphisms between AD patients and controls. The possible functional importance of genetic variability associated with this gene was tested by plasmatic ELISA detection of GRN on eighty AD patients. Stratifying the results according to rs1990622 SNP status, no significant differences in progranulin plasma levels were found in AD patients. Regarding OLR1, in particular it was analyzed the SNP rs1050283 T/C, located in 3’UTR of the gene. Logistic regression analysis, adjusted for gender and ApoE status, showed a statistically significant association of OLR1 rs1050283 under the assumption of a dominant and a genotypic model. Therefore this SNP could be considered a susceptibility factor for sporadic AD. Given that the SNP rs1050283 is also located in a predicted binding site of the miRNA has-miR369-3p, a preliminary expression analysis was performed on the two transcripts in the PBMC in order to clarify a possible functional role of individual genetic variability on the expression of OLR1 gene. Stratifying the results according to the presence of rs1050283C allele, a significant decrease of relative expression levels of OLR1 was observed in patients carrying at least one polymorphic C allele, despite the normal expression levels of has-miR369-3p. These data suggest that the presence of the polymorphic allele could influence the binding of has-miR369-3p to its 3’UTR consensus sequence, in which the SNP is located
Un crocevia settecentesco: la 'Donna serpente' di Carlo Gozzi
No full textIl saggio analizza la presenza del tema folklorico della 'donna-serpente' nell'omonima 'Fiaba teatrale' di Gozzi
Il ruolo del capitale intellettuale nel successo delle strategie di merger & acquisition delle start-up
No full textThe article proposes a case study of a Merger and Acquisition (M&A) processes in Italy between a temporary agency and an innovative start-up. The aim of the study is to investigate which component of the intellectual capital affects the trust of the companies involved in the M&A process. Results show the key role of trust in start-up’s human capital for the integration of the innovative service into the acquiring company. We suggest that the success of the M&A is given by our model named “circular vision of intellectual capital”
Innate immune system and inflammation in Alzheimer's disease : from pathogenesis to treatment
No full textImmune activation and inflammation, likely triggered by amyloid-beta (Aβ) deposition, play a remarkable role in the pathogenesis of Alzheimer's disease (AD), which is the most frequent cause of dementia in the elderly. The principal cellular elements of the brain innate immune system likely to be involved in such processes are microglia. In an attempt to search for new disease-modifying drugs, the immune system has been addressed, with the aim of removing deposition of Aβ or tau by developing vaccines and humanized monoclonal antibodies. The aim of this review is to summarize the current evidence regarding the role played by microglia and inflammatory molecules in the pathogenesis of AD. In addition, we will discuss the main active and passive immunotherapeutic approaches
Frammento di scultura marmorea : serpente
No full textUn frammento marmoreo raffigurante un serpente viene descritto e commentato per stabilirne il possibile significato nello specifico contesto dei bagni medievali, ma anche tenendo conto della varietà di rimandi che l'iimmagine del serpente ha assunto in età classica.A marble fragment of a snake is described and briefly discussed in order to establish its significance in the specific context of the medieval baths but also considering the polysemy of the iconography in the classical period
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