1,720,972 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
The functional VNTR of IGH enhancer HS1.2 associates with human longevity and interacts with TNFA promoter diplotype in a population of Central Italy
No full textThe dysregulation of both immune and inflammatory responses occurring with aging is believed to substantially contribute to morbidity and mortality in humans. We have already reported the association of the functional Variable Number of Tandem Repeat (VNTR) at the Immunoglobulin heavy chain (. IGH) enhancer HS1.2 with Immunoglobulin levels and with several autoimmune diseases. Herein we tested the association of the VNTR at the HS1.2 enhancer with human longevity, also evaluating the possible modulatory effect of TNFA promoter diplotype (rs361525/rs1800629). HS1.2 enhancer genotypes have been determined for 193 unrelated healthy individuals from Central Italy divided into two groups: Group 1 (18-84. yrs, mean age 56.8. ±. 19.4) and Group 2 (85-100. yrs, mean age 93.0. ±. 3.5). Homozygous subjects for *2 allele were significantly disadvantaged in reaching higher life-expectancy (OR. =. 0.457, p. =. 0.021). A significant interaction between TNFA promoter diplotype status, HS1.2 2/2 genotype and the two Groups was found (p. =. 0.014). Of note, TNFA -. 308A allele seems to exert a protective effect in HS1.2 2/2 carriers. These results support the hypothesis of an important role of HS1.2 VNTR in the puzzle of the immune-system regulation, evidenced also by the potential interaction with TNFA. Moreover, the previous results showing the association of HS1.2 *2 allele with inflammatory phenomena are consistent with the hypothesis that this allele is a detrimental factor in reaching advanced age
Association between Psoriasis and haplotypes of the IgH3' Regulatory Region 1
No full textThe association studies of several immune-diseases with the 3' Regulatory Region
1 (3'RR1) increased interest on the role that the region plays in the
immune-regulation. The 3'RR1 is a polymorphic region on human chromosome 14q32,
acting as a cis-regulative element on the Immunoglobulin constant-gene locus
recently considered as super-enhancer. The human 3'RR1 share large sequences with
its paralogous 3'RR2, at high level of similarity. Thus, a focused investigation
was necessary to discriminate each one of the duplicated components of the two
regions and its specific contribution to the immunologic phenotype. One of the
duplicated elements is the hs1.2 enhancer. The 3'RR1 alleles of this enhancer
were demonstrated to play a role in autoimmune diseases, including Psoriasis. We
sequenced a specific region internal to the 3'RR1 in hs1.2 homozygous subjects,
to detect SNPs associated to the main alleles of the enhancer. We identified two
alternative nine-SNPs haplotypes strictly linked to the allele *1 and *2 of
hs1.2, that could be used as markers to further investigate the region and
associations to pathology. Finally, we identified two haplotypes, namely E2A1 and
E2A2, that strongly support the hypothesis of a relevant effect of the rs35216181
in the onset of Psoriasis when the *2 allele is present
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Genomic comparison of the sequenze contributing to the 3D structure of the IgH3’ regulatory region (≥30kb) in vertebrates: conservation of a large palindromic structure with a polymorphism on the internal enhancer
No full textDispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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