102,173 research outputs found
Cell directional [persistence] and chemotaxis in vascular morphogenesis
No full text[120328.EG In WebOfScience risulta mancare la parola 'persistence' nel titolo.
G. Bellomo, Profili pubblicistici del Data Protection Officer nel sistema multilivello di tutela della privacy, Napoli, Editoriale Scientifica, 2020, pp. 268
No full textRecensione al volume di Gianluca Bellomo dal titolo "Profili pubblicistici del Data Protection Officer nel sistema multilivello di tutela della privacy", figura introdotta con il Regolamento (UE) 2016/679. In particolare, l'analisi è stata condotta sui profili pubblicistici a questa inerenti nel sistema multilivello di tutela della privacy
Supplementation with canthaxanthin affects plasma and tissue distribution of and γ-tocopherols in mice
No full textThe effects of oral doses of canthaxanthin on tissue distribution of α- and γ-tocopherols were investigated in three experiments in male and female Balb/c mice. Mice were assigned to receive canthaxanthin [7 or 14 μg/(g body weight. d)] or placebo (olive oil) by gavage for different periods of time (0, 1, 2, 4 and 6 wk). A 2 wk-treatment with canthaxanthin resulted in incorporation of the carotenoid in all tissues analyzed, including liver, spleen, kidney, lung and heart. In liver, the maximum accumulation of the carotenoid was reached after 2 wk of dosing in female mice and after 6 wk in male mice. Canthaxanthin incorporation was accompanied by changes in α- and γ-tocopherol concentrations in plasma and tissues. These included the following: 1) a significant increase (P < 0.001) in α-tocopherol concentration in spleen (21 and 27% in male and female mice, respectively) after 2 wk and in liver (~50% in both male and female mice) after 6 wk; 2) a significant decrease in γ-tocopherol concentration in plasma (P < 0.05) and tissues (P < 0.001) after 2 wk of treatment. In female mice, this decrease was 55% in plasma, 43% in liver, 44% in kidney, 71% in lung and 70% in heart. In male mice, the decrease was observed only in plasma (30%), kidney (54%) and heart (46%). In liver, the decrease in γ-tocopherol concentration was both dose- and time-dependent and significantly (P < 0.001) greater in female than in male mice. We conclude that dietary administration of canthaxanthin modifies tocopherol status in murine tissues
Treatment of crusted scabies with acitretin
No full textWe present two cases of crusted scabies who were successfully treated with acitretin. Case 1. An 83-year-old woman was admitted to our Department because of a crusted dermatitis. The patient stated that she was in therapy with metoprolol and levodopa/benserazide for essential arterial hypertension and Parkinson's disease. The patient also stated that the dermatitis had appeared approximately six months earlier. It was diagnosed at other centres as allergic contact dermatitis and unsuccessfully treated with topical and oral corticosteroids, and oral anti-histamines
New Insights on the Effects of Dietary Omega-3 Fatty Acids on Impaired Skin Healing in Diabetes and Chronic Venous Leg Ulcers
No full textLong-chain Omega-3 polyunsaturated fatty acids (Omega-3 PUFAs) are widely recognized as powerful negative regulators of acute inflammation. However, the precise role exerted by these dietary compounds during the healing process is still largely unknown, and there is increasing interest in understanding their specific effects on the implicated cells/molecular factors. Particular attention is being focused also on their potential clinical application in chronic pathologies characterized by delayed and impaired healing, such as diabetes and vascular diseases in lower limbs. On these bases, we firstly summarized the current knowledge on wound healing (WH) in skin, both in normal conditions and in the setting of these two pathologies, with particular attention to the cellular and molecular mechanisms involved. Then, we critically reviewed the outcomes of recent research papers investigating the activity exerted by Omega-3 PUFAs and their bioactive metabolites in the regulation of WH in patients with diabetes or venous insufficiency and showing chronic recalcitrant ulcers. We especially focused on recent studies investigating the mechanisms through which these compounds may act. Considerations on the optimal dietary doses are also reported, and, finally, possible future perspectives in this area are suggested
Percolative analysis of 3D vasculogenesis
No full textVascular networks form by the spontaneous aggregation of individual cells migrating toward vascularization sites (vasculogenesis). The study of this fascinating process is performed by biologists using in vitro and in vivo assays, both in twodimensional and threedimensional settings. A succesfull theoretical model of twodimensional experimental vasculogenesis has been recently proposed, showing the relevance of percolation concepts and of cell cross-talk (chemotactic autocrine loop) to the understanding of the self-aggregation process. Here we study the natural 3D extension of the earlier proposed computational model, which we take as a starting point for the investigation of the genuinely threedimensional process of vasculogenesis in vertebrate embryos. The computational model is based on a multidimensional Burgers equation, which is a well studied paradigm in the research on spontaneous pattern formation, integrated with a feedback term describing the chemotactic autocrine loop. The numerical approximation of the computational model poses several technical problems which are here briefly discussed. Starting from initial conditions mimicking the experimentally observed ones the numerical simulations produce network-like structures qualitatively similar to those observed in the early stages of in vivo vasculogenesis. Following the lesson learned in the twodimensional case, we develop the computation of critical percolative indices as a robust measure of the network geometry
Nutraceutical-Based Nanoformulations for Breast and Ovarian Cancer Treatment
No full textDifferent strategies have been investigated for a more satisfactory treatment of advanced breast cancer, including the adjuvant use of omega-3 polyunsaturated fatty acids (PUFAs). These nutritional compounds have been shown to possess potent anti-inflammatory and antiangiogenic activities, the capacity to affect transduction pathways/receptors involved in cell growth and to reprogram tumor microenvironment. Omega-3 PUFA-containing nanoformulations designed for drug delivery in breast cancer were shown to potentiate the effects of enclosed drugs, enhance drug delivery to target sites, and minimize drug-induced side effects. We have critically analyzed here the results of the most recent studies investigating the effects of omega-3 PUFA-containing nanoformulations in breast cancer. The anti-neoplastic efficacy of omega-3 PUFAs has also been convincingly demonstrated by using preclinical in vivo models of ovarian cancer. The results obtained are critically analyzed here and seem to provide a sufficient rationale to move to still lacking interventional clinical trials, as well as to evaluate possible advantages of enclosing omega-3 PUFAs to drug-delivery nanosystems for ovarian cancer. Future perspectives in this area are also provided
Xanthan gum-based materials for omega-3 PUFA delivery: Preparation, characterization and antineoplastic activity evaluation.
No full textXanthan gum-based microspheres and hydrogels, useful for targeted colorectal release of omega-3 polyunsaturated fatty acids (PUFAs), were successfully prepared and characterized. In particular, the microsphere size,as well as the hidrogel swelling degree at pH7.4, and the omega-3 PUFA loading efficiency of both the materials suggested their suitability for colorectal delivery. Moreover, the antioxidant efficiency of the xanthan gum based materials suggests their ability to protect the omega-PUFA cargo. We demonstrated that α-linolenic acid (ALA 18:3ω-3) carried by the materials increased significantly its ability to reduce colorectal cancer cell growth in vitro.On the contrary, docosahexaenoic acid (DHA, 22:6ω-3) enclosed in the hydrogel formulation did
not enhance its already high anti-neoplastic potential. The improved anti-neoplastic efficacy of ALA enclosed in both the xanthan gum-based formulations further supports the hypothesis of a potential use of this omega-3 PUFA as a suitable and more sustainable alternative to thefish-derived DHA
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