61 research outputs found
EVALUATION OF PHOTOPOLYMERIZABLE HEMA-BASED HYDROGELS FOR RELEASE OF ANTI-DIABETIC DRUG METFORMIN HCL
No full textThis study targets to prepare a metformin hydrochloride delivery system through the preparation and evaluation of 2-hydroxyl ethyl methacrylate (HEMA) based hydrogels. The current study explores the effect of photoinitiator (Irgacure 184, Irgacure 651), PEG-DA derivatives, 4-Acryloyl morpholine (4-AcM), and gelatine obtained by UV photopolymerization of HEMA hydrogels. Photopolymerization technique which was under UV irradiation was implemented at 365 nm and 300 s. Two different photoinitiators [2,2- Dimethoxy-2-phenyl-acetophenone (Irgacure 651)], [1-Hydroxycyclohexyl phenyl ketone (Irgacure 184)] were used to obtain the impact of photoinitiators on the metformin HCl release behavior of samples. In addition, PEG-DA Mn=258, PEG-DA Mn=700, 4-AcM, and gelatine were used to improve HEMA hydrogels. The prepared hydrogels have been characterized using Fourier transform infrared spectroscopy (FT-IR) and a digital microscope. The behaviors of hydrogels were specified by exploring swelling and release profiles in different medias. In-vitro metformin HCl release analyses have been done at pH 1.2, 6.8, and 7.4. UV-Vis spectrophotometer at 244 nm for releasing studies was used. The release results of hydrogels synthesized with Irgacure 651 demonstrated the majority quantity of the drug. Furthermore, the release amounts were higher in pH 1.2 than at mentioned pH medias before
Evaluation of Different Types of Paracetamol Active Pharmaceutical Ingredients' Effects on the Release System
No full textThe primary purpose of this study was to investigate the effect of active pharmaceutical ingredients (APIs) with varying particle sizes and properties on drug release and to develop matrix-type tablets based on poly(acrylic acid sodium salt) (PAANa) with different gelatin ratios for enhanced paracetamol release. Micronized, superfine, and purified paracetamol APIs were selected as model drugs to assess the impact of these APIs on drug release. Paracetamol is a frequently used medication in healthcare, so it is crucial to select the API with the optimal release rate and an economical, environmentally friendly production method. The direct compression method was employed in the preparation of the tablets due to its simplicity and ease of integration on an industrial scale. The release studies, release kinetics, scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FT-IR), physical properties, and microbial analyses (Escherichia coli, total mold, yeast) were investigated. The release studies at pH 1.2 and pH 7.4 revealed that the type of active pharmaceutical ingredient, especially micronized paracetamol API and superfine API, affects the paracetamol release ratio. Microbial analyses showed that produced tablets were convenient for health. In addition, prepared tablets with added gelatine can be used to deliver paracetamol with the desired release profile
Preparation and characterization of pH-sensitive hydrogels from photo-crosslinked poly(ethylene glycol) diacrylate incorporating titanium dioxide
No full textThe purpose of the present investigation was to prepare pH-sensitive hydrogels from photo-crosslinked poly(ethylene glycol) diacrylate (PEG-DA). Rutile titanium dioxide (TiO2) was employed to modify the PEG-DA hydrogels. The rutile titanium dioxide (TiO2) nanoparticles were prepared by direct oxidation of titanium in the presence of polyethylene glycol (PEG) at high temperature. The nanoparticles were characterized by FT-IR, XRD and SEM. The influence of experimental conditions, such as pH, type and amount of photoinitiators on the release profiles of donepezil hydrochloride (active pharmaceutical ingredient for Alzheimer disease) from modified PEG-DA hydrogels, was investigated. The drug release processes were analyzed kinetically using zero-order, first-order, Hixson-Crowell and Peppas models
Study on the preparation and drug release property of Modified PEG-DA based hydrogels
No full textThe aim of the present study is to develop hydroxyapatite modified PEG-DA and PEG-DA/HEMA based hydrogels for release of Donepezil HCl for potential treatment of Alzheimer’s disease. [2,2-Dimethoxy-2-phenyl-acetophenone] (Irgacure 651), 1 Hydroxycyclohexyl phenyl ketone (Irgacure 184) and 2-Hydroxy-4'-(2-hydroxyethoxy)-2-methylpropiophenone (Irgacure 2959) were used as photo-initiators in the synthesis of hydrogels and hydroxyapatite was used for modifying hydrogels. Fourier transform infrared spectroscopy (FT-IR), scanning electron microscope (SEM) and digital microscope were utilized to investigate the characteristics properties of hydrogels. Photopolymerization technique was selected to synthesize for hydrogels. Swelling and drug release studies have been performed under different pH conditions
Synthesis and characterization of hydrogels based on poly(2-hydroxyethyl methacrylate) for drug delivery under UV irradiation
No full textThe present study aims to create a controlled release system through the preparation and characterization of hydrogels based on 2-hydroxyl ethyl methacrylate (HEMA). In order to investigate the influence of photo-initiators on the drug release behavior of the resulting hydrogels, three different photo-initiators [2,2-dimethoxy-2-phenyl-acetophenone] (Irgacure 651), 1-hydroxycyclohexyl phenyl ketone (Irgacure 184) and 2-hydroxy-4'-(2-hydroxyethoxy)-2-methylpropiophenone (Irgacure 2959) were used. In addition, hydroxyapatite (HAp) was employed to modify HEMA hydrogels. The synthesis of hydrogels was confirmed by characterization through Fourier transform infrared spectroscopy, nuclear magnetic resonance (C-13 NMR) spectroscopy and digital microscope. The responsive behaviors were investigated by recording swelling ratios under different conditions. In vitro drug release studies were performed for donepezil hydrochloride-loaded hydrogels at pH 1.2, 6.8 and 7.4. The results indicated that hydrogels synthesized using Irgacure 2959 released the maximum amount of donepezil hydrochloride. Moreover, the release rate decreased in the presence of HAp
The brexit negotiations: The next battleground for French-U.K. relations
No full textIn March 2017, following the successful referendum in the UK to leave the European Union in June of 2016, negotiations began to discuss the policies regarding the official exit of the United Kingdom with Theresa May’s declaration of Article 50. In recent developments associated with the Brexit negotiations, more ties have been seen between the UK and France than other member-states of the EU. Given the long history between France and the UK, it is clear that the Brexit negotiations have become the next battleground for UK-French unrest. This essay responds to the strength of the theory of intergovernmentalism within the context of the Brexit negotiations and how the leadership role established by France in the wake of Brexit is a phenomenon based on their economic interests, a desire to advance their position as an international actor, and their deep-rooted, historical discontent for one another. Through analyzing a series of most-read newspapers from both countries, the research has shown the battleground of French-UK relations as taking place in these three categories with national interests being more pertinent in the Brexit negotiations than international relations.Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2020-05-01The student, Emilee McArdle, accepted the attached license on 2018-04-19 at 11:28.The student, Emilee McArdle, submitted this Thesis for approval on 2018-04-19 at 13:20.This Thesis was approved for publication on 2018-04-19 at 15:24.DSpace SAF Submission Ingestion Package generated from Vireo submission #12377 on 2018-08-31 at 17:21:02Made available in DSpace on 2018-09-04T20:36:48Z (GMT). No. of bitstreams: 2
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Does neutrophil to lymphocyte ratio demonstrate deterioration in renal function?
No full textIntroduction: Chronic kidney disease (CKD) is a major health issue worldwide, which leads to end-stage renal failure and cardiovascular events. Neutrophil to lymphocyte ratio (NLR) is a surrogate marker of inflammation and has been widely studied in malignancies, hypertension, heart diseases, and vascular diseases. In this study, we aimed to investigate if NLR represents renal reserve and function after partial or radical nephrectomy. Methods: We conducted a retrospective study consists of patients who had undergone radical/partial nephrectomy in our hospital and/or who admitted to urology and nephrology clinics as an outpatient. Patients were divided into four groups: Group 1 (n = 46): Healthy controls; Group 2 (n = 50): Patients who had undergone unilateral partial nephrectomy; Group 3 (n = 46): Patients who had gone unilateral nephrectomy; Group 4 (n = 82): Patients who had CKD. Results: The mean NLR of each group was as follows: Group 1: 2.14 ± 0.73; Group 2: 3.52 ± 3.74; Group 3: 3.64 ± 3.52, and Group 4: 3.53 ± 2.30. NLR was lower in Group 1 compared to other groups but statistically significant difference was observed only between Group 1 (control) and Group 4 (CKD), 2.14 ± 0.73 versus 3.53 ± 2.30 (p = .005). In non-parametric correlation analysis NLR was found negatively correlated with GFR and positively correlated CKD stage (p = .028 for both correlations). Conclusions: The NLR may constitute a practical predictor of CKD besides Cr in patients who had undergone partial or radical nephrectomy
Toward a Deleuzean theory of translation: a translation of and commentary on A fuego eterno condenados
No full textThis translation and commentary thesis presents a theory of literary translation
based on the ideas of Gilles Deleuze, informed by and applied to a translation
of parts 0, 1 and 2 of the novel A fuego eterno condenados (1994) by Chilean author
Roberto Rivera Vicencio. Using an approach based on the iterative development
of a theoretical framework and translation, it examines how specific translation
problems from the text can contribute to and benefit from a translation theory
based on the ideas of Deleuze. Analysing the work of Lawrence Venuti as
indicative of a shift by Translation Studies from thinking of translation in terms
of equivalence to thinking of it in terms of difference, the thesis builds on
Venuti’s research, offering a systematic treatment of Deleuze’s earlier work
to theorise translation as the production of simulacra in which the translator
creates solutions in the domain of the Actual to a translation problem that exists
in the Virtual. It then goes on to examine Deleuze’s later work, written in
collaboration with F´elix Guattari, to develop a conceptual framework based on
the concept of the texture of prose derived from the principles of a minor, or
nomad, science. This framework is used to address specific problems arising
in the translation, deriving a series of practical techniques and considerations
that can be used to create this kind of texture in the application of a Deleuzean
theory of translation to literary texts
AN ASPECT OF LOCAL PROPERTY OF FOURIER SERIES
No full textWOS: 000419402200004In this paper, a general theorem concerning vertical bar(N) over bar, p(n), theta(n)vertical bar(k) summability factors of Fourier series is obtained. Using this result we study a localization problem for Fourier series.Ahi Evran University Scientific Research Projects Coordination Unit [FEF.A4.17.004]This work was supported by Ahi Evran University Scientific Research Projects Coordination Unit. Project Number: FEF.A4.17.004 and the author would like to thank the referees for a careful reading and several constructive comments that have improved the presentation of the results
A Variation on Absolute Weighted Mean Summability Factors of Fourier Series and its Conjugate Series
No full textWOS: 000486985000006In this paper, theorems concerning vertical bar(N) over bar, p(n), theta(n)vertical bar(k) factors of Fourier series and its conjugate series are studied. The presented results are generalizations two theorems of Mazhar on conjugate series and Fourier series.Ahi Evran University Scientific Research Projects Coordination UnitAhi Evran University [FEF.A4.17.004]The author would like to express her sincerest thanks to the referee for valuable suggestions for the improvement of this paper. This work was supported by Ahi Evran University Scientific Research Projects Coordination Unit. Project Number: FEF.A4.17.004
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