130 research outputs found
The value of androgen receptor and CD10 expression in cutaneous basal cell carcinoma and trichoepithelioma
No full textSengul, Ilker/0000-0001-5217-0755WOS: 00036186300002
Interpretations on preconditioning with lidocaine and xylazine in experimental equine jejunal ischaemia
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Frequency of helicobacter pylori and association of location, six age groups, and assessment of borderline of 50-year base-age, based on the anatomic pilot region with the degree of helicobacter pylori colonization
No full textSengul, Ilker/0000-0001-5217-0755WOS: 000455468900010Objective: The aim of this study is to detect the Helicobacter pylori frequency and also to evaluate the connection of the location, age groups with the degree of Helicobacter pylori colonization. Materials and Methods: The histopathology results of endoscopic gastric mucosal samples of 373 cases, between February 2009 and February 2013, based on updated Sydney System had been retrospectively analysed. The existance of Helicobacter pylori had been investigated according to six age groups. Results: The Helicobacter pylori was detected as at Least one positive, 206 (552%) and negative, 167 (44.8%). Helicobacter pylori was positive for 73 of 147 (49.7%) in corpus and 114 of 197 (579%) in antrum. No difference was detected between the general stomach (p=0.292), antrum (p=0.896) and corpus (p=0.184), age groups and also new subgroup (over and under 50, in the antrum) and the Helicobacter pylori colonization. Conclusion: The Helicobacter pylori positivity was 55.2% in general and observed mostly in the antrum and 45-64 age group, while no any difference was detected between the location, age groups, subgroups with over and under 50 and the degree of Helicobacter pylori colonization
Association between Tsukuba elasticity scores 4 and 5 on elastography and Bethesda undetermined cytology on US-guided FNA with 27-G needle, verified by histopathology: a cut-off point of 20 mm of diameter designated for thyroid nodules
No full textSengul, Ilker/0000-0001-5217-0755WOS: 000458202600052PubMed: 30941995Purpose: The purpose of this study was to assess the performance of strain elastography (SE) in predicting malignancy for the thyroid nodules with undetermined cytology, Bethesda categories III and IV. The cut-off point was 20 mm of a thyroid nodule. Methods: A retrospective analysis from April 2012 to April 2016 was conducted by examining the records of 547 consecutive eligible patients with 655 thyroid nodules, the undetermined cytology of which surgery had been recommended. Results: A sum of 655 nodules in 547 patients were studied. Eighty-two (12.5%) of 655 thyroid nodules were Bethesda Category III and IV (undetermined cytology). Of the 655 thyroid nodules examined, 401 (61.2%) were less than 20 mm and 254 (38.8%) were more than 20 mm in diameter. No significant difference was detected between nodule sizes more than 20 mm in diameter and Tsukuba Elasticity score (TES) 4 and 5 by McNemar test and 0.677 area under the curve (AUC). No significant difference was detected between nodule sizes over 20 mm in diameter and Bethesda III and IV (undetermined cytology) by McNemar test and 0.632 AUC. In addition, no significant difference was detected between nodule size with the cut-off value of 20 mm and the histopathology of the thyroidectomies by McNemar test and 0.607 AUC. Conclusion: Nodules size 20 mm in diameter was not a useful cut-off point for distinguishing malignant from benign thyroid nodules among the nodules with TES 4 and 5, Bethesda III and IV, and malignant histopathology
Risk stratification of the thyroid nodule with Bethesda indeterminate cytology, category III, IV, V on the one surgeon-performed US-guided fine-needle aspiration with 27-gauge needle, verified by histopathology of thyroidectomy : the additional value of one surgeon-performed elastography
No full textBackground: The aim is to assess the value of strain elastography (SE) in differentiating likelihood of malignancy for the thyroid nodules, possessing the Bethesda Category III, IV, and V indeterminate cytology.
Methods: The data was obtained by ultrasonography (US)-guided fine-needle aspiration (US-g-FNA) via 27-gauge needle, with the verification of indicated thyroidectomies in a retrospective analysis, from April 2010 to April 2014, by enrolling the documents of 262 consecutive patients, with 327 thyroid nodules, subjected to one-surgeon performed neck US, SE, and US-g-FNA with 27-G needle to rule out the malignancy.
Results: 122 of 327 cases were Bethesda Category III, IV, and V with histopathologically benign, 110 (90.2%); PTC, 7 (5.7%); FTC, 4 (3.3%); HCC, 1 (0.8%). Tsukuba Elasticity Score (TES) 1, 2, 3, 4, and 5 were detected as 38 (31.1%), 8 (6.6%), 59 (48.4%), 4 (3.3%), and 13 (10.7%), respectively for the cases with the indeterminate cytology. No significant difference was detected between TES 4 and 5 and malign histopathology by McNemar test (p = .727) with a good level of concordance, the kappa coefficient, 0.737.
Conclusion: SE may be a useful tool in differentiating malign from benign thyroid nodules by selecting surgery adaptation even for Bethesda indeterminate cytology on FNAC
Gangrenous meckel's diverticulum in a strangulated umbilical hernia in a 42-year-old woman: a case report
No full textIntroduction: Meckel's diverticulum affects 1 - 3 % of general population and is known as the most common anomaly of gastrointestinal tract. However, its estimated lifetime complication rate is approximately 4 %. Intestinal obstruction is most common complication of Meckel's diverticulum in adult population. Case presentation: In the present study, we reported a 42-year-old female patient with a gangrenous Meckel's diverticulum in a strangulated umbilical hernia sac treated by dissection of diverticulomesenteric bands and diverticulectomy. In 36 months follow-up, there was neither any complication nor recurrence of hernia. Conclusion: This case represents a gangrenous Meckel's diverticulum in a strangulated umbilical hernia sac diagnosed in case of emergency. Although it is a very rare phenomenon, we should be vigilant for this entity especially in case of emergency. © 2010 Sengul et al
Ectomesenchymal chondromyxoid tumor of the anterior tongue: A rare case
No full textAbstractEctomesenchymal chondromyxoid tumor is a rare tumor seen in the anterior dorsal aspect of the tongue. Diagnosis of this lesion without a prediagnosis clinically is made only with histopathological findings including the immunohistochemical examinations. However, diverse results are being reported in the literature with keratin staining. While glial fibrillary acid protein positiveness maintain being a fixed repeating feature, we emphasized for our case of a 28-year-old Caucasian woman having the findings of qualities supporting the ectomesenchymal origin of the mentioned tumor
Cd10 For The Distinct Differential Diagnosis Of Basal Cell Carcinoma And Benign Tumours Of Cutaneous Appendages Originating From Hair Follicle
No full textAims: Differential diagnosis between the group of trichoadenoma, trichofolliculoma, trichoepithelioma, trichoblastoma and basal cell carcinoma has been creating some difficulties for the pathologist and the clinicians, particularly in the presence of small specimens. Material and methods: A total of 30 cases of benign tumours of cutaneous appendages originating from the hair follicle and 30 cases of basal cell carcinoma were retrieved from the archives deposited from 2004 to 2008. Results: The expression of CD10 in both tumours was graded from [0] to [2+] for each case. The immunoreactivity of CD10 was comparatively examined among the groups and each subgroup. The stromal CD10 immunopositivity of benign tumours of cutaneous appendages originating from the hair follicle was stronger than the other (p = 0.003) regarding both the numerical and the degree of expression. However, peripheral CD10 of basal cell carcinoma was stronger than the other for [1+] immunopositivity (p = 0.03). It was exact opposite for [2+] (p = 0.013). Besides, central CD10 immunopositivity and CD10 reactivity for the subgroups was not significant. Conclusions: CD10 may be very useful for the differential diagnosis between them particularly in the small and superficial biopsies and it may be even a life-saving method in some selected cases.Wo
Population-based cervical screening outcomes in Turkey over a period of approximately nine and a half years with emphasis on results for women Aged 30-34
No full textSengul, Ilker/0000-0001-5217-0755; Korkmazer, Engin/0000-0001-8318-2329WOS: 000335651200030PubMed: 24716936Purpose: To appraise the frequency of cervical cytological abnormalities in a population at normal risk via analysing the archive records of cytology for the period of approximately 9,5 years, comparing them with patient demographic charecteristics, and discuss the results for women under age of 35. Materials and Methods: A total of 32,578 cases of Pap smears were retrieved and analysed from our archive included the Pap tests performed between January 2001 and April 2010 at the Early Cancer Screening, Diagnosing and Education Center by the consent of three pathologists via utilizing the Bethesda System Criteria 2001 and the results were compared with some demographical characteristics. Results: Our rate of the cervical cytological abnormality was 1.83%, with ASCUS in 1.18%, LSIL in 0.39, HSIL in 0.16%, AGUS in 0.07%, squamous cell carcinoma in 0.02%, and adenoarcinoma in 0.006%. Cytological abnormalities were detected mostly in those with higher age, lower parity, and premenopausal period whereas the smoking status was without influence. Bacterial vaginosis (5.6%) was the most frequent infectious finding (Candida albicans 2.7%; Actinomyces sp. 1.3%; and Trichomonas vaginalis 0.2%) detected on the smears. The rate of abnormal cervical cytology was 9.5% among the women aged between 30-34. Conclusions: Early detection of the cervical abnormalities by means of the regular cervical cancer screening programmes is useful to attenuate the incidence, mortality, and morbidity of cervical cancer. Our prevalence of the cytological abnormalities was much lower than the one in Western populations in general but very similar to those reported from other Islamic countries that may be explained by the conservative lifestyle and the lower prevalence of HPV in Turkey. A remarkable rate of abnormal cervical cytology of women aged 30-34 was pointed out in the present study
Essays on monetary economics
No full textIn my dissertation, I attempt to shed new light on the impact of central bank behavior. The first chapter proposes indexes of monetary policy design characteristics in line with inflation targeting (IT). Indexes aim to provide a useful classification of central banks and to examine whether IT intensity matters for sacrifice ratio and inflation persistence. Results show that U.S. and Japan are ranked close to early targeters. Armenian central bank is detected to perform remarkably well as opposed to the literature's descriptions. Noteworthy structural changes are noticed in Mexico and Peru. Higher index level significantly reduces OECD countries' inflation persistence through increased transparency. Higher intensity among targeters does not deliver significantly lower sacrifice ratio or inflation persistence. Announcing official targets does not provide additional benefits. Low degree of central bank discretion and limited financing of the government significantly decrease the sacrifice ratio among OECD countries and in the full cross-sectional sample respectively. Institutional design features need to be mature enough in order to benefit from inflation targeting. The second chapter examines the usefulness of monetary aggregates. A number of dynamic stochastic general equilibrium models (DSGE) and econometric time series models are jointly specified; including vector autoregressive (VAR), random walk (RW), and various autoregressive (AR) and AR with exogenous variable type models (ARX). Model performance is evaluated via novel testing methods developed for assessing predictive and simulation accuracy. Money is found to matter for inflation simulation purposes in simple econometric models, such as ARX models. With regard to predictive point and density analysis, when complex models are examined, M2 enters into the forecast-best VAR-type inflation models. Model selection is found to be sensitive to researcher’s objective function, to target variable and forecast horizon. Particularly, when the objective is policy analysis, the examination of multivariate models show that DSGE-type models often outperform at longer horizons and mainly for output forecasts. In contrast, VAR-type models win for simulation purposes and short-horizon inflation forecasts. However, univariate models without money generally dominate theoretical and atheoretical multivariate models both with and without money from both forecasting and simulation standpoint.Ph. D.Includes bibliographical referencesIncludes vitaby Demet Tunal
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