43 research outputs found
Expression of Cyclin D1 and its relationship to hormone receptors and survival in breast cancer
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Reply to “Proper tumor classification and growth rate are key elements when considering indications and results of radiotherapy for head and neck paragangliomas”
No full textSCOPUS: le.jDecretOANoAutActifinfo:eu-repo/semantics/publishe
Adjuvant radiotherapy for uterine carcinosarcoma: A retrospective assessment of treatment outcomes
No full textObjectives: the objective of the study is to understand the impact of adjuvant radiotherapy (RT) and prognostic factors for patients diagnosed with uterine carcinosarcoma.Materials and Methods: the records of 31 patients receiving adjuvant RT between the dates of September 2003-January 2013 in our clinic were evaluated retrospectively. Surgery was performed in 27 (87%) patients as staging laparotomy, for 4 patients as total abdominal hysterectomy and bilateral salpingo-oophorectomy. Pelvic external beam radiotherapy (EBRT) was 4500-5040 cGy in 25-28 fractions. in addition, 23 patients received brachytherapy following EBRT, 12 patients received adjuvant, and 1 patient received neoadjuvant chemotherapy (CT).Results: the median age was 63 (between 30 and 78). the stage distribution of the patients was as follows: Stage I, 20 (64%); Stage II, 7 (23%), and Stage III, 4 (13%) patients. Five-year locoregional control (LRC) rate was 100%, disease-free survival (DFS) and overall survival (OS) rates were 65.5% and 66.2%, respectively. Stage I or II patients have a tendency for better 5-year OS and DFS rates than Stage III patients (73.1% vs. 42.9% and 72.7% vs. 42.9%; P = 0.065 and 0.051). Regarding lymph node dissection was performed or not, 5-year OS (64.7% vs. 75.0%) was not statistically different between groups (P = 0.77). Five-year OS and DFS rates were 69.2% and 61.5% for patients receiving CT (adjuvant or neoadjuvant) versus 63.7% and 68.8% for patients not receiving CT; P = 0.63 and P = 0.89, respectively. Based on the analysis of peritoneal washings, 5-year OS was 0% for patients with malignant or suspicious cytology whereas 89% for patients with benign cytology (P = 0.000). A negative correlation was observed between mitotic count of sarcomatous component and DFS time (rs = -0.812 and P = 0.05).Conclusions: Surgery and adjuvant RT seem beneficial for excellent LRC rate. However, survival rates are low due to distant metastases. Thus, there is a great need for better systemic therapies
Analysis of some simple policies for dynamic resource allocation
No full textComplexity-performance trade-offs are investigated for dynamic resource allocation in load sharing networks with Erlang-type statistics. The emphasis is on the performance of simple allocation strategies that can be implemented on-line. The resource allocation problem is formulated as a stochastic optimal control problem. Variants of a simple least load routing policy are shown to lead to a fluid type limit and to be asymptotically optimal. Either finite capacity constraints or migration of load can be incorporated into the setup.Three policies, namely optimal repacking, least load routing, and Bernoulli splitting, are examined in more detail. Large deviations principles are established for the three policies in a simple network of three consumer types and two resource locations and are used to identify the network overflow exponents. The overflow exponents for networks with arbitrary topologies are identified for optimal repacking and Bernoulli splitting policies, and conjectured for the least load routing policy.Finally, a process-level large deviations principle is established for Markov processes in the Euclidean space with a discontinuity in the transition mechanism along a hyperplane. The transition mechanism of the process is assumed to be continuous on one closed half-space and also continuous on the complementary open half-space. A similar result was recently obtained by Dupuis and Ellis for lattice-valued Markov processes satisfying a mild communication/controllability condition. The proof presented here relies on the work of Blinovskii and Dobrushin, which in turn is based on an earlier work of Dupuis and Ellis.Made available in DSpace on 2011-05-07T12:02:05Z (GMT). No. of bitstreams: 2
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Radiosensitization of HER2-positive breast cancer cell lines with trastuzumab
No full text49th Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO) -- MAY 31-JUN 04, 2013 -- Chicago, ILAmer Soc Clin Onco
Evaluation of unusual and highly aggressive variant of endometrium cancer: nonendometrioid endometrium carcinoma of the uterus
No full textAims: To evaluate the survival and treatment outcomes of patients with nonendometrioid endometrium carcinoma after postoperative radiotherapy. Methods: The records of 94 patients treated with postoperative radiotherapy (RT) between January 2005 and December 2011 were retrospectively reviewed. Postoperative RT was delivered with a dose of 45-50.4 Gy with 1.8 Gy daily fractions and brachytherapy was added to external RT for 62 patients with a dose of 3 x 6 Gy. Median follow-up time was 35 months (range 6-95 months). Results: Median age was 63 years (range 43-83 years) and lymph node metastasis (LNM) was positive in 15 (16.0%) patients. The stage distribution of the patients was as follows: stage I, 58 (61.7%); stage II, 16 (17.0%); stage III, 18 (19.1%); stage IV, 2 (2.2%). Five-year locoregional control (LRC), disease-free survival (DFS), and overall survival (OS) rates were 92.3%, 68.2%, and 78.6%, respectively. In univariable analysis, it was determined that the factors affecting OS rates were stage (p = 0.003), presence of LNM (p = 0.003), and presence of lymphovascular space invasion (LVSI) (p = 0.007); factors affecting DFS rates were stage (p = 0.019), presence of LVSI (p = 0.002), and having LNM (p = 0.049); and the factor affecting LRC rates was tumor size (>5 cm) (p = 0.011). In subgroup analyses, among all stage I patients, the DFS rates were lower for those with histologic grade 3 tumors and more than 1/2 myometrial invasion. Conclusions: Due to its rarity, the prognostic factors and outcomes of nonendometioid endometrium carcinoma are not fully understood. In our analysis, stage, LNM, and presence of LVSI were found to be the most important prognostic factors. In order to tailor the optimal treatment strategy, prospective studies are needed
Comparison of The International Federation of Gynecology and Obstetrics (FIGO) 2018 and 2009 Staging Systems for Operated Cervical Carcinoma
No full textOBJECTIVE The purpose of the study was to compare FIGO 2009 and 2018 uterine cervical carcinoma staging systems in terms of patient distribution and efficacy in predicting treatment outcome in patients treated with surgery and adjuvant radiotherapy (RT)+/-concomitant chemotherapy (CT). METHODS The records of 184 uterine cervical cancer patients treated with post-operative RT/RCT from 2007 to 2017 were retrospectively reviewed. Surgical procedure was in the form of Wertheim surgery in 96 patients (52%) and pelvic lymph node dissection was performed in 32 patients (17.5%). One hundred and sixty-six patients (87.5%) received both external RT and intracavitary brachytherapy, and 23 (12.5%) patients were treated only with external RT. RESULTS The median follow-up time was 61.5 months (range, 8-132 moths). One hundred and fifty-one (82%) patients were alive, and 144 (94%) of these were free of disease at the time of this analysis. The median time for locoregional failure and distant metastasis were 25 months (range, 8-88 months) and 38 months (range, 12-118 months). Stage migration was recorded in 130 patients (70.7%) in our series when the International Federation of Gynecology and Obstetrics (FIGO) 2018 staging system was used. The most remarkable stage migration was detected for Stage I patients. A total of 119 (64.6%) patients with Stage I showed stage migration. Five-year locoregional control, disease-free survival, disease-specific survival, and overall survival rates were 91%, 88%, 91%, and 83%, respectively. CONCLUSION The updated FIGO staging system for invasive cervical cancer incorporates imaging and pathological findings. Our results suggest us that the major improvement of 2018 staging system for uterine cervical carcinoma is that it produced better discrimination in terms of survival outcome in patients with lymph node metastases both pelvic and para-aortic
Taxonomic and ecologic investigation of malacostraca (crustacea) fauna in the freshwaters of Samsun and Sinop
No full textBu tezin, veri tabanı üzerinden yayınlanma izni bulunmamaktadır. Yayınlanma izni olmayan tezlerin basılı kopyalarına Üniversite kütüphaneniz aracılığıyla (TÜBESS üzerinden) erişebilirsiniz.ÖZET SAMSUN VE SİNOP İLLERİ İÇSULARININ MALACOSTRACA (CRUSTACEA) FAUNASININ TAKSONOMİK VE EKOLOJİK AÇIDAN İNCELENMESİ AKBULUT, Mehmet Doktora Tezi, Su Ürünleri Ana Bilim Dalı Tez Yöneticisi: Prof. Dr. Ruşen USTAOĞLU Bu çalışmada Sinop ve Samsun illeri tatlısu Malacostraca (Crustacea) faunası kalitatif olarak incelenmiştir. Şubat 1999-Ekim 2000 tarihleri arasında Sinop ve Samsun ili içsularında belirlenen 181 istasyondan örnekler toplanmış, istasyonların sıcaklık, tuzluluk, pH, elektriki iletkenlik ve bulanıklıkları tespit edilmiştir. Bu çalışma sonucunda, 4 ordo ve 1 1 familyaya ait 19 tür ve 4 alt tür tespit edilmiştir. Bulunan türlerden Limnomysis benedeni Türkiye faunası için yeni kayıttır. Diğer türlerden Palaemon elegans, Palaemon adspersus, Crangon crangon, Carcinus aestuarü, Gammarus komareki, Gammarus uîudagi, Gammarus longipedis, Gammarus balcanicus, Echinogammarus ischnus, Stygobromus ambulans, Orchestia stephenseni, Idotea hectica, Sphaeroma serratum, Paramysis kosswigi verilen lokalitelerde ilk defa tespit edilmişlerdir. Astacus leptodactylus leptodactylus, Potamon ibericum tauricum, Gammarus pulex pulex, Gammarus aequicauda, Niphargus valachicus, Orchestia cavimana, Asellus aquaticus ve Idotea baltica basteri önceden verilen lokalitelerde tekrar tespit edilmişlerdir. Anahtar Sözcükler: Sinop, Samsun, Malacostraca, tatlısu, acısuVII ABSTRACT TAXONOMIC AND ECOLOGIC INVESTIGATION OF MALACOSTRACA (CRUSTACEA) FAUNA IN THE FRESHWATERS OF SAMSUN AND SINOP AKBULUT, Mehmet PhD in Fishery Faculty Supervisor: Prof. Dr. Ruşen USTAO?LU In this study, the freshwater Malacostraca fauna of Sinop and Samsun was studied qualitatively. The materials were sampled in 181 stations in the freshwaters of Sinop and Samsun region and water temperature, salinity, pH, conductivity and turbidity were measured between February 1999-October 2000. At the end of the study, 19 Malacostraca species and 4 subspecies belonging to 4 order and 1 1 families were recorded. Of the established species Limnomysis benedeni is a new record for the Turkish fauna. Of the other species Palaemon elegans, Palaemon adspersus, Crangon crangon, Carcinus aestuarii, Gammarus kamareki, Gammarus uludagi, Gammarus longipedis, Gammarus balcanicus, Echinogammarus ischnus, Stygobromus ambulans, Orchestia stephenseni, Idotea hectica, Sphaeroma serratum, Paramy&is kosswigi were firstly recorded in given localities, Astacus leptodactylus leptodactylus, Potamon ibericwn tauricum, Gammarus pulex pulex, Gammarus aequicauda Niphargus valachicus, Orchestia cavimana, Asellus aquaticus ve Idotea baltica basteri were found again in their known localities. Keywords: Sinop, Samsun, Malacostraca, freshwater, brackish water
TREATMENT RESULTS OF STAGE IIIC2 LOCALLY ADVANCED CERVICAL CANCER PATIENTS TREATED WITH RADIOCHEMOTHERAPY
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