1,732,570 research outputs found

    University-local industry linkages : the case of Tohoku University in the Sendai area of Japan

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    This paper focuses on Tohoku University in Sendai in the nonmetropolitan area of Japan. Both a long historical and comparative perspective and a spacial perspective are essential to discuss the relevance of university-local industry linkages to local regional economic development. The conjunction of these linkages and economic development has been affected by two evolutionary processes: institutional configurations and territorial dynamics in the national innovation system. In addition, university-local industry linkages have been complicated by top-down regionalization and bottom-up regionalism.Tertiary Education,ICT Policy and Strategies,Agricultural Knowledge&Information Systems,Technology Industry,Rural Development Knowledge&Information Systems

    仙台市の日本語学校外国人留学生のスポーツ関心に関する調査

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    Building a multicultural society, where both Japanese and foreigners accept the cultural differences mutually and live together in harmony, is being conducted around Japan recently. Especially Miyagi prefecture has also put effort into it. As Olympic seen, sports can contribute to building multicultural society. However, there is no prior research on awareness survey of foreigners in Sendai city, Miyagi prefecture. This research was conducted to foreigner students in three Japanese Language school in Sendai city in August 2023. Many of survey respondents are young students from South Asian countries. The survey showed the difference of sports customs between Japanese and them, and the problems that make them enjoy sports insufficiently.departmental bulletin pape

    Activation of the beta interferon promoter by paramyxoviruses in the absence of virus protein synthesis

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    Conflicting reports exist regarding the requirement for virus replication in interferon (IFN) induction by paramyxoviruses. Our previous work has demonstrated that pathogen-associated molecular patterns capable of activating the IFN-induction cascade are not normally generated during virus replication, but are associated instead with the presence of defective interfering (DI) viruses. We demonstrate here that DIs of paramyxoviruses, including parainfluenza virus 5, mumps virus and Sendai virus, can activate the IFN-induction cascade and the IFN-beta promoter in the absence of virus protein synthesis. As virus protein synthesis is an absolute requirement for paramyxovirus genome replication, our results indicate that these DI viruses do not require replication to activate the IFN-induction cascade.Peer reviewe

    Marco de Sendai para la Reducción del Riesgo de Desastres : 2015-2030

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    Sendai (Japón), 14-18 de marzo de 2015El Marco de Sendai para la Reducción del Riesgo de Desastres 2015-2030 se adoptó en la tercera Conferencia Mundial de las Naciones Unidas celebrada en Sendai (Japón) el 18 de marzo de 2015. Este es el resultado de una serie de consultas entre las partes interesadas que se iniciaron en marzo de 2012 y de las negociaciones intergubernamentales que tuvieron lugar entre julio de 2014 y marzo de 2015, con el apoyo de la Oficina de las Naciones Unidas para la Reducción del Riesgo de Desastres, a petición de la Asamblea General de las Naciones Unidas

    Integration of a virus membrane protein into the lipid bilayer of target cells as a prerequisite for immune cytolysis

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    Structural requirements for membrane antigens on target cells to mediate immune cytolysis were studied in a model system with purified membrane proteins from Semliki Forest virus (SFV). These SFV spike proteins were isolated in the form of detergent- and lipid-free protein micelles (29S complexes) or, after reconstitution into lipid vesicles, in the form of virosomes. Both the 29S complexes and the virosomes were found to bind well to murine tumor cells (P815 or Eb). When these cells, however, were used as target cells in complement-dependent lysis or in antibody-dependent cell- mediated cytotoxicity assays in the presence of anti-SFV serum, they were not lysed, although they effectively bound the antibody and consumed complement. The same tumor cells infected with SFV served as positive controls in both assays. Different results were obtained when inactivated Sendai virus was added as a fusion reagent to the cells coated with either virosomes or 29S complexes. Under these conditions the virosome-coated cells became susceptible to SFV- specific lysis, whereas the 29S complex-coated cells remained resistant. Evidence that the susceptibility to lysis ofvirosome-coated cells was dependent on active fusion and, therefore, integration of the viral antigens into the lipid bilayer of the target cells was derived from control experiments with enzyme-treated Sendai virus preparations. The 29S complexes and the virosomes partially and selectively blocked the target cell lysis by anti-H-2 sera but not by anti-non-H-2 sera confirming our previous finding that major histocompatibility antigens serve as receptors for SFV. The general significance of these findings for mechanisms of immune cytolysis is dicussed
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