3,301 research outputs found

    Criminal Law – Let judges fix all life tariffs

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    Colin Bob-Semple reviews five decisions in English courts that have highlighted the need for reform of the procedure for fixing tariff periods for life prisoners. Article by Colin Bobb-Semple (Senior Lecturer, Inns of Court School of Law) published in Amicus Curiae - Journal of the Institute of Advanced Legal Studies and its Society for Advanced Legal Studies. The Journal is produced by the Society for Advanced Legal Studies at the Institute of Advanced Legal Studies, University of London

    Criminal Law – Let judges fix all life tariffs

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    Colin Bob-Semple reviews five decisions in English courts that have highlighted the need for reform of the procedure for fixing tariff periods for life prisoners. Article by Colin Bobb-Semple (Senior Lecturer, Inns of Court School of Law) published in Amicus Curiae - Journal of the Institute of Advanced Legal Studies and its Society for Advanced Legal Studies. The Journal is produced by the Society for Advanced Legal Studies at the Institute of Advanced Legal Studies, University of London

    Colin Humphris

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    "Colin Humphris 2 Sqdrn. RAAF. 1941 - 1942 Author of - 'Trapped on Timor' (as a result of bombing of Darwin Feb. 19, 1942)".Colin Humphris. 2 Squadron, Royal Australian Air Force 1941 - 1942. Author of - 'Trapped on Timor' (as a result of bombing of Darwin February 19, 1942)

    Integrative modeling reveals the principles of multi-scale chromatin boundary formation in human nuclear organization

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    BACKGROUND: Interphase chromosomes adopt a hierarchical structure, and recent data have characterized their chromatin organization at very different scales, from sub-genic regions associated with DNA-binding proteins at the order of tens or hundreds of bases, through larger regions with active or repressed chromatin states, up to multi-megabase-scale domains associated with nuclear positioning, replication timing and other qualities. However, we have lacked detailed, quantitative models to understand the interactions between these different strata.RESULTS: Here we collate large collections of matched locus-level chromatin features and Hi-C interaction data, representing higher-order organization, across three human cell types. We use quantitative modeling approaches to assess whether locus-level features are sufficient to explain higher-order structure, and identify the most influential underlying features. We identify structurally variable domains between cell types and examine the underlying features to discover a general association with cell-type-specific enhancer activity. We also identify the most prominent features marking the boundaries of two types of higher-order domains at different scales: topologically associating domains and nuclear compartments. We find parallel enrichments of particular chromatin features for both types, including features associated with active promoters and the architectural proteins CTCF and YY1.CONCLUSIONS: We show that integrative modeling of large chromatin dataset collections using random forests can generate useful insights into chromosome structure. The models produced recapitulate known biological features of the cell types involved, allow exploration of the antecedents of higher-order structures and generate testable hypotheses for further experimental studies.</p

    Interview with Colin Wilson, part 4, undated

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    Interview with Colin Wilson, part 4, features an interview with author Colin Wilson in which he discusses his views regarding society and art, his reclusive nature, and the intellectual and fantastical elements of his works, undated

    Interview with Colin Wilson, part 2, undated

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    Interview with Colin Wilson, part 2, features an interview with author Colin Wilson in which he discusses his views regarding society and art, his reclusive nature, and the intellectual and fantastical elements of his works, undated

    Providence College Faculty Author Series 2017-2018: D. Colin Jaundrill

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    In this installment of the Faculty Authors Series, D. Colin Jaundrill (History, Providence College) discusses his newest book, Samurai to Soldier: Remaking Military Service in Nineteenth-Century Japan

    Providence College Faculty Author Series 2017-2018: D. Colin Jaundrill

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    In this installment of the Faculty Authors Series, D. Colin Jaundrill (History, Providence College) discusses his newest book, Samurai to Soldier: Remaking Military Service in Nineteenth-Century Japan

    Interview with Colin Jerolmack

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    Colin Jerolmack is an Assistant Professor at New York University in Sociology and Environmental Studies. He is the author of The Global Pigeon (forthcoming) and an alumnus of the Robert Wood Johnson Foundation Scholars in Health Policy Program at Harvard University
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