1,721,022 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Anti-HLA class I monoclonal antibody effect on PKC kinetics in PHA activated human peripheral blood mononuclear and E+ cells
No full textAn anti-HLA class I monoclonal antibody alters the progression in the cell cycle of phitohemagglutinin-activated human T lymphocytes
No full textThe effect of exposure to urinary pheromones on the extracellular levels of aspartate, glutamate, GABA and taurine in the amygdala of male and female rats
No full textAdaptive value of a PKC.PKI55 feedback loop of inhibition that prevents the kinase's deregulation.
No full textInternational-DMD (IDMD): a PTC Therapeutics-supported diagnostic project to widely identify Dystrophin mutations by NGS technologies
No full textExtensive molecular diagnosis in genetic diseases is vital to confirm clinical diagnosis and to enable genetic counseling and personalized management. Duchenne muscular dystrophy (DMD) is a rare genetic neuromuscular disease affecting 1 in 5.000 male births worldwide, due to a variety of dystrophin gene mutations. Since 2016, PTC Therapeutics International Ltd. and the University of Ferrara, Italy, have established a collaboration focused on identifying patients affected by rare genetic disorders through increased genetic testing activities, with an initial focus on DMD. Genetic testing is available to patients throughout European countries and other regions. Diagnostic settings include MLPA (MRC-Holland) and NGS dystrophin gene sequencing (Multiplicom). Currently, DNAs from Poland (50), Hungary (17), Lituania (6), Romania (7), Russia (1), Bosnia (4), Croatia (2) Bulgaria (13) Cyprus (2), Ucraina (1) and Algeria (40) were collected for a total of 143 samples. Analyses have been completed in 125 patients. MLPA screening identified 35 samples with large deletions/duplications, while NGS analysis identified 31 nonsense, 15 small del/dup, 15 splice site and 3 missense mutations. Twenty-six (26) patients were negative for both MLPA and NGS analyses, suggesting the presence of atypical mutations. Notably, among the small mutations identified (64) about 50% are nonsense and 25% are canonical splice site mutations. The early identification of the underlying genetic mutation is critical for the standard of care including treatment choice and eligibility for clinical trials. Genetic counselling can also be offered to patients and families via a telegenetics service (www.ospfe.it/medicalgenetics)
Adaptative value of a PKC-PK155 feedback loop of inhibition that prevents the kinase's deregulation
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