1,720,978 research outputs found
Blood Pressure After Endovascular Thrombectomy and Outcomes in Patients With Acute Ischemic Stroke: An Individual Patient Data Meta-analysis
No full textObjective: To explore the association between blood pressure (BP) levels after endovascular thrombectomy (EVT) and the clinical outcomes of acute ischemic stroke (AIS) patients with large vessel occlusion (LVO). Methods: A study was eligible if it enrolled AIS patients older than 18 years, with an LVO treated with either successful or unsuccessful EVT, and provided either individual or mean 24-hour systolic BP values after the end of the EVT procedure. Individual patient data from all studies were analyzed using a generalized linear mixed-effects model. Results: A total of 5874 patients (mean age: 69±14 years, 50% women, median NIHSS on admission: 16) from 7 published studies were included. Increasing mean systolic BP levels per 10 mm Hg during the first 24 hours after the end of the EVT were associated with a lower odds of functional improvement (unadjusted common OR=0.82, 95%CI:0.80-0.85; adjusted common OR=0.88, 95%CI:0.84-0.93) and modified Ranking Scale score≤2 (unadjusted OR=0.82, 95%CI:0.79-0.85; adjusted OR=0.87, 95%CI:0.82-0.93), and a higher odds of all-cause mortality (unadjusted OR=1.18, 95%CI:1.13-1.24; adjusted OR=1.15, 95%CI:1.06-1.23) at 3 months. Higher 24-hour mean systolic BP levels were also associated with an increased likelihood of early neurological deterioration (unadjusted OR=1.14, 95%CI:1.07-1.21; adjusted OR=1.14, 95%CI:1.03-1.24) and a higher odds of symptomatic intracranial hemorrhage (unadjusted OR=1.20, 95%CI:1.09-1.29; adjusted OR=1.20, 95%CI:1.03-1.38) after EVT. Conclusion: Increased mean systolic BP levels in the first 24 hours after EVT are independently associated with a higher odds of symptomatic intracranial hemorrhage, early neurological deterioration, three-month mortality, and worse three-month functional outcomes.Objective: To explore the association between blood pressure (BP) levels after endovascular thrombectomy (EVT) and the clinical outcomes of acute ischemic stroke (AIS) patients with large vessel occlusion (LVO). Methods: A study was eligible if it enrolled AIS patients older than 18 years, with an LVO treated with either successful or unsuccessful EVT, and provided either individual or mean 24-hour systolic BP values after the end of the EVT procedure. Individual patient data from all studies were analyzed using a generalized linear mixed-effects model. Results: A total of 5874 patients (mean age: 69±14 years, 50% women, median NIHSS on admission: 16) from 7 published studies were included. Increasing mean systolic BP levels per 10 mm Hg during the first 24 hours after the end of the EVT were associated with a lower odds of functional improvement (unadjusted common OR=0.82, 95%CI:0.80-0.85; adjusted common OR=0.88, 95%CI:0.84-0.93) and modified Ranking Scale score≤2 (unadjusted OR=0.82, 95%CI:0.79-0.85; adjusted OR=0.87, 95%CI:0.82-0.93), and a higher odds of all-cause mortality (unadjusted OR=1.18, 95%CI:1.13-1.24; adjusted OR=1.15, 95%CI:1.06-1.23) at 3 months. Higher 24-hour mean systolic BP levels were also associated with an increased likelihood of early neurological deterioration (unadjusted OR=1.14, 95%CI:1.07-1.21; adjusted OR=1.14, 95%CI:1.03-1.24) and a higher odds of symptomatic intracranial hemorrhage (unadjusted OR=1.20, 95%CI:1.09-1.29; adjusted OR=1.20, 95%CI:1.03-1.38) after EVT. Conclusion: Increased mean systolic BP levels in the first 24 hours after EVT are independently associated with a higher odds of symptomatic intracranial hemorrhage, early neurological deterioration, three-month mortality, and worse three-month functional outcomes
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Χρησιμοποιώντας τεχνικές επιλογής μεταβλητών στη μετα-ανάλυση δικτύου
No full textThe current thesis aims to address two common challenges encountered in network meta-analysis (NMA), the evaluation of consistency and the handling of multi-component interventions. Consistency assessment is vital as the validity of the NMA findings is primary affected by the satisfaction of this assumption. Significant discrepancies between direct and indirect evidence may lead to biased NMA estimates. In particular, a brief overview of (N)MA and the standard method used to evaluate consistency is presented. Additionally, a novel method for identifying inconsistencies is proposed that evaluates network consistency both globally and locally. This was accomplished by integrating the Stochastic Search Variable Selection method into the NMA framework and treating inconsistency factors as variables in a generalized linear model. Historical evidence and differences between direct and indirect evidence that are considered of practical significant, can be also incorporated into the inconsistency detection process. The performance of the proposed method was evaluated in two published networks under various scenarios. Furthermore, to facilitate the implementation of the method, the user-friendly R-package ssifs was developed and published on CRAN. Concerning the handling of multi-component interventions, novel ways of visualizing NMA results are proposed that allow for the easy identification of the most efficacious components, exploration of the network’s geometry and examination of the components’ behaviour. To implement these tools, the user-friendly R-package viscomp was developed and published on CRAN. Lastly, some concluding remarks and suggestions for future research are provided.Η συγκεκριμένη διατριβή στοχεύει στην αντιμετώπιση δύο συχνών προβλημάτων που συναντώνται στην μετα-ανάλυση δικτύου, την αξιολόγηση της υπόθεσης της συνέπειας και τον χειρισμό παρεμβάσεων πολλών συνιστωσών. Η αξιολόγηση της υπόθεσης της συνέπειας είναι κομβικής σημασίας, καθώς η αξιοπιστία των αποτελεσμάτων της μετα-ανάλυσης δικτύου εξαρτάται σε μεγάλο βαθμό από αυτή την υπόθεση. Μεγάλες διαφορές μεταξύ άμεσης και έμμεσης πληροφορίας μπορεί να οδηγήσει σε μεροληπτικά αποτελέσματα. Στην διατριβή αρχικά γίνεται μια ανασκόπηση της μετα-ανάλυσης και της μετα-ανάλυσης δικτύου, καθώς και των συχνών μεθόδων που χρησιμοποιούνται για την αξιολόγηση της υπόθεσης της συνέπειας. Έπειτα παρουσιάζεται μια καινοτόμα μέθοδος για την εύρεση ασυνεπειών στο δίκτυο, η οποία έχει την δυνατότητα να ανιχνεύει τοπικά που υπάρχουν ασυνέπειες και να αξιολογεί γενικά το δίκτυο αν πληρεί την υπόθεση της συνέπειας. Αυτό επιτυγχάνεται αντιμετωπίζοντας το μοντέλο της μετα-ανάλυσης δικτύου ως ένα μοντέλο παλινδρόμησης και χρησιμοποιώντας την μέθοδο στοχαστικής αναζήτησης επιλογής μεταβλητών. Σημαντικά πλεονεκτήματα που προσφέρει η προτεινόμενη μέθοδος είναι η δυνατότητα εύρεσης ασυνεπειών χρησιμοποιώντας εξωτερική πληροφορία, και η εύρεση ασυνεπειών βάσει διαφορών που θεωρούνται πρακτικά σημαντικές. Η προτεινόμενη μέθοδος αξιολογήθηκε σε δύο δημοσιευμένα δίκτυα μετα-ανάλυσης υπό διάφορα σενάρια. Επιπρόσθετα, για την εύκολη χρήση της μεθόδου, κατασκευάστηκε το στατιστικό πακέτο ssifs, το οποίο είναι δημοσιευμένο στο CRAN. Αναφορικά με τον χειρισμό παρεμβάσεων πολλών συνιστωσών, προτείνονται νέοι τρόποι οπτικοποίησης των αποτελεσμάτων της μετα-ανάλυσης δικτύου, οι οποίοι επιτρέπουν την εύκολη εύρεση των πιο αποτελεσματικών συνιστωσών, την διερεύνηση του δικτύου και της συμπεριφοράς των συνιστωσών. Για την εύκολη χρήση των προτεινόμενων εργαλείων οπτικοποίησης των αποτελεσμάτων της μετα-ανάλυσης δικτύου, κατασκευάστηκε το στατιστικό πακέτο viscomp, το οποίο είναι δημοσιευμένο στο CRAN. Τέλος παρατίθενται ορισμένες καταληκτικές παρατηρήσεις και προτάσεις για μελλοντική έρευνα
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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