29 research outputs found
Prevention and management of adverse events related to regorafenib
No full textRegorafenib is an oral multikinase inhibitor that has shown antitumor activity in a range of solid tumors. Based on data from phase III clinical trials, regorafenib is indicated for the treatment of adult patients with metastatic colorectal cancer who have previously been treated with, or are not considered candidates for, other available therapies, and in patients with advanced gastrointestinal stromal tumors that cannot be surgically removed and no longer respond to other appropriate treatments. A panel of oncology nurses, research coordinators, and other medical oncology experts, experienced in the care of patients treated with regorafenib, met to discuss the best practice for the management of regorafenib-associated adverse events (AEs). The panel agreed that, in clinical trials and daily practice with regorafenib, AEs are common but mostly manageable. The most common and/or important AEs associated with regorafenib were considered to be hand-foot skin reaction, rash or desquamation, stomatitis, diarrhea, hypertension, liver abnormalities, and fatigue. This manuscript describes the experience and recommendations of the panel for managing these AEs in everyday clinical practice. Appropriate education, monitoring, and management are considered essential for reducing the incidence, duration, and severity of regorafenib-associated AEs. © 2013 The Author(s)
The New Orleans Reformed Public School System: National Model?
No full textThe author describes what happened to the New Orleans Public Schools after Hurricane Katrina
Unraveling the SES-Health Connection
No full textWhile a debate rages on about competing reasons why SES may affect health, there is little recognition that the so-called reverse causation from health to economic status may be pretty fundamental as well. Even if the direction of causation is that SES mainly affects health, what dimensions of SES actually matter—the financial aspects such as income or wealth or non-financial dimensions like education? Finally, is there a life course component to the health gradient so that we may be mislead in trying to answer these questions by only looking at people of a certain age—say those past 50. This paper, which is divided into four sections, provides my answers to these questions. The first section examines the issue of reverse causation or whether a new health event has a significant impact on four dimensions of SES—out-of-pocket medical expenses, labor supply, household income, and household wealth. The next section switches the perspective by asking whether the so-called direct causation from SES to health really matters all that much. If the answer is yes and it will be, a sub-theme in this section concerns which dimensions of SES—income, wealth, or education—matter for individual health. Since the answer to that question turns out to be education, Section 3 deals with the very much more difficult issue of why education matters so much. The evidence in these first three sections relies on data for people above age 50. In the final section of the paper, I test the robustness of my answers to these basic questions of the meaning of the SES-health gradient using data that span the entire life-course.
Birmingham News sleeve BN0059289
No full textZone / Eastern area landfill expansion / Meet Mickey Hamilton at Eastern Area Landfill to look at land clearing going on and discuss status of landfill and plans for expansion. (No land is being acquired, but the area in use is being expanded.) Some Trussville residents apparently are not happy about this, because I have heard you can see the expensive Tutwiler Farms subdivision on a hill across the valley from the landfill. / Robert / Karen Natalie / Andrew / 14 months / Jacksonville / John Grant - sitting up / Raynard Escot / Stephen Faucher - assistant director streets and sanitation / Doug Harbison - assistant landfill operations supervisor / [Work order included
The license of author's right (copyright)
No full textLe droit d'auteur – dont l'identité reste controversée – n'échappe pas à la discussion quant à la nature et au régime des contrats qui le mettent en œuvre. D'une terminologie légale ancrée dans une certaine tradition, mais hasardeuse, on infère l'originalité de l'ensemble des contrats de la matière. Or, la spécificité n'est sur ce point qu'apparente. De l'édition littéraire aux contrats de l'audiovisuel et aux œuvres diffusées sur les réseaux, l'analyse démontre que si l'auteur peut "céder" son œuvre – ce que dit la loi – il peut aussi la louer, c'est-à-dire en concéder la licence – ce qu'elle ne dit pas. Ce constat s'appuie sur une méthode de lecture renouvelée des contrats du droit d'auteur. L'attention portée par la loi impérative à certains contrats (édition, production audiovisuelle, etc.), a pu perturber l'étude de la licence, l'acte par lequel l'auteur se borne à autoriser l'exploitation de son œuvre pour un temps. Or, si la licence apparaît dans un premier temps en contrat spécial du droit d'auteur, elle sera également amenée à devenir la composante élémentaire d'un contrat complexe organisant une exploitation. Il importe donc de distinguer ces deux objets pour mieux en apprécier ensuite les interactions. Le droit d'auteur, droit "spécial", fait ainsi la preuve de son aptitude à accueillir - autant que de raison - les mécanismes du droit des contrats, droit "commun". Cette étude a pour ambition une meilleure compréhension de cette matière complexe des contrats du droit d'auteur, sans omettre le principal objectif de notre loi : la protection de l'auteur.In the field of the author's right (a concept with a controversial identity), the nature and regime of many contracts is a subject for debate. A traditional but somehow uncertain terminology has often led to infer the originality of most of these contracts. However, this peculiarity is only apparent. From literary publishing to audiovisual contracts through creations published on networks, not only can the author of a work "assign" it – as stated by the law – but also rent it, or in other words license it – even though the law does not state it. This observation rests on a renewed reading method applied to the author's right contracts. Focusing on some of these contracts (e. g. books publishing, audiovisual production, etc.), mandatory copyright law hindered the study of license itself, i. e. the act by which an author authorizes the exploitation of his work for a fixed time. License is a special contract in the field of author's right ; it is also a basis element in a complex agreement designed to organize an exploitation. These two objects should therefore be distinguished and their interactions thoroughly analysed. A "special" right, the author's right nevertheless proves able to host (to a certain extent) the typical process of contract right – a "common" right. The present study aims to attain a better understanding of a complex matter, the author's right contracts, not forgetting the main purpose of the law itself : the protection of the author
La licence de droit d'auteur
No full textThèse, version de soutenance.Référence thèse publiées (LexisNexis 2013) : Alexis Boisson. La licence de droit d'auteur: Préface J. Raynard. LexisNexis, 785 p., 2013, Collection Bibliothèque de droit de l'entreprise, 978-2-7110-1869-7. 〈hal-01967284〉In the field of the author’s right (a concept with a controversial identity), the nature and regime of many contracts is a subject for debate.A traditional but somehow uncertain terminology has often led to infer the originality of most of these contracts. However, this peculiarity is only apparent. From literary publishing to audiovisual contracts through creations published on networks, not only can the author of a work « assign » it – as stated by the law – but also rent it, or in other words license it – even though the law does not state it. This observation rests on a renewed reading method applied to the author’s right contracts.Focusing on some of these contracts (e. g. books publishing, audiovisual production, etc.), mandatory copyright law hindered the study of license itself, i. e. the act by which an author authorizes the exploitation of his work for a fixed time. License is a special contract in the field of author’s right ; it is also a basis element in a complex agreement designed to organize an exploitation. These two objects should therefore be distinguished and their interactions thoroughly analysed.A « special » right, the author’s right nevertheless proves able to host (to a certain extent) the typical process of contract right – a « common » right. The present study aims to attain a better understanding of a complex matter, the author’s right contracts, not forgetting the main purpose of the law itself : the protection of the author.Le droit d’auteur – dont l’identité reste controversée – n’échappe pas à la discussion quant à la nature et au régime des contrats qui le mettent en oeuvre. D'une terminologie légale ancrée dans une certaine tradition, mais hasardeuse, on infère l’originalité de l’ensemble des contrats de la matière. Or, la spécificité n’est sur ce point qu’apparente. De l’édition littéraire aux contrats de l’audiovisuel et aux oeuvres diffusées sur les réseaux, l’analyse démontre que si l’auteur peut « céder » son oeuvre – ce que dit la loi – il peut aussi la louer, c'est-à-dire en concéder la licence – ce qu’elle ne dit pas.Ce constat s’appuie sur une méthode de lecture renouvelée des contrats du droit d’auteur. L’attention portée par la loi impérative à certains contrats (édition, production audiovisuelle, etc.), a pu perturber l’étude de la licence, l’acte par lequel l’auteur se borne à autoriser l’exploitation de son oeuvre pour un temps. Or, si la licence apparaît dans un premier temps en contrat spécial du droit d’auteur, elle sera également amenée à devenir la composante élémentaire d’un contrat complexe organisant une exploitation. Il importe donc de distinguer ces deux objets pour mieux en apprécier ensuite les interactions. Le droit d’auteur, droit « spécial », fait ainsi la preuve de son aptitude à accueillir – autant que de raison – les mécanismes du droit des contrats, droit « commun ». Cette étude a pour ambition une meilleure compréhension de la matière complexe des contrats du droit d’auteur, sans omettre le principal objectif de notre loi : la protection de l’auteur. [NDLA : la version présentée ici est la version "de soutenance", telle que soutenue devant le jury de thèse le 9 décembre 2011 et telle que présentée au CNU (874 p.) - Pour la version éditée, réduite et mise à jour : Alexis Boisson. La licence de droit d'auteur: Préface J. Raynard. LexisNexis, 785 p., 2013, Collection Bibliothèque de droit de l'entreprise, 978-2-7110-1869-7. ⟨hal-01967284⟩
Information Technology Risk Management Analysis on Money Transfer Services in Post Offices Using Framework Standardization ISO 22301
No full textState-Owned Enterprises (BUMN) have realized the importance of information technology, one of which is PT. POS (PERSERO) Indonesia. The purpose of this study is to analyze the management of Information Technology that is currently running at PT. POS (Persero) Indonesia lhokseumawe branch, to find out the Capability Level. The Post Office is an organization engaged in the delivery of goods. The organization has used information technology to support business activities. Money transfer is an application that is used to record every shipment of goods made by consumers starting from the data of the sender of the goods, the data of the goods, and the data of the recipient of the goods. However, it is undeniable that every risk that occurs can interfere with the performance of the money transfer application. Therefore, it is necessary to analyze the risk of the information technology used. In this study, researchers tried to implement the ISO 22301 risk management framework to see every possible risk contained in the money transfer application. The final result of this research is expected to help organizations in seeing and knowing what actions must be taken against any possible risks or threats that occur around the money transfer application based on the level of ris
Enacting social accounting within a community enterprise : actualising hermeneutic conversation
No full textThe research was carried out using a participatory action research approach to develop social accounts with Jesmond Swimming Pool (JSP). The original motivation to carry out this project was to see what social accounts would look like and whether it was possible to develop them in this organisation. The experience of doing social accounts is further examined using Gray, et al., (1997) to explore whether these were either ‘ideal’ or ‘good’ social accounts for the organisation. A communitarian philosophical framework is used in order to examine the conceptualisation of ‘good’ social accounts.
The first part of the thesis explores the social and environmental accounting (SEA) and accountability literature, with the second part exploring the experience of reaching initial agreement to do social accounts (SAs). The agreement to do the accounts was then followed by two years of social accounts developed with JSP. This empirical data provides a detailed account from the perspectives of insiders and other sources as to the experience of doing social accounts. This experience is then opened up to interrogation from a wider view point.
The third part of the thesis examines the experience of JSP using third sector communitarian philosophy and a voluntary accountability framework in order to demonstrate that JSP could provide an example of a ‘good’ or ‘ideal’ social account. This raises the issue of whether or not ‘good’ or ‘ideal’ social accounts for third sector organisations are only possible within a communitarian paradigm. If it is possible to establish what ‘good’ social accounts entail then it may be appropriate to extend this approach to other contexts, for example, the public sector or the corporate world
OPTIMASI PENEMPATAN HRS PT PLN DI BALI UNTUK FUEL CELL ELECTRIC VEHICLE (FCEV): KAJIAN KEAMANAN DAN BIAYA
No full textJika membutuhkan abstrak atau isi jurnal silahkan menghubungi author melalui e-mail [email protected] atau [email protected]
Dipublikasikan tanggal: 15 Juli 202
Prof. Jansen is interviewed by Michael Bossinger from MFM after being announced a winner at the NSTF (National Science & Technology Foundation) awards
No full textIn order to listen to this interview, please download a Media Player, eg. Winamp available at http://winamp.com/player/Prof. Jonathan Jansen was announced a winner at the (NSTF) National Science & Technology Foundation awards in the following category: ESKOM Research Capacity Development Awards: Researcher, for Research Capacity Development over the last 5-10 years. In this interview Lorenzo Raynard asked him the following questions:
1. How did he become a black dean at a white university?
2. What are the challenges that he faces?
3. Which experiences have helped him in his work?
4. What are the challenges for the South African education curriculum?
5. Future developments?
6. How does he see South Africa's position at the moment?
7. What does he have to say about the salaries of teachers?
8. What does he think of UK teacher working environments in comparison to those in South Africa?
9. What are the limitations of teachers?
10. If he could be in charge of the education budget, where would he see the money going?
11. What does he have to say to young people considering a career in teaching?
12. Last words from the deanMichael Bossinger who conducted the interview, is from MFM which is Stellenbosch University’s campus radio station. This was part of a national project of the NSTF to use a convergence of ICTs which included campus radio stations, to ensure knowledge transfer between the NSTF Award winners and students
