5,302 research outputs found
Juvenile papillomatosis of the breast in a male infant with Noonan syndrome, Cafe au Lait spots, and family history of breast carcinoma
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Quantification of ante-mortem hypoxic ischemic brain injury by post-mortem cerebral magnetic resonance imaging in neonatal encephalopathy
No full textChronicle (Paterson, NJ) Vol. 34, No.47, Nov. 18, 1962
No full textLocal information pertaining to Paterson, N.J. and surrounding Passaic County. Issues may include events, government, business, political cartoons, engagement and marriage announcements, and birth announcements. This publication was also known as the Paterson Chronicle (1952) and the Paterson Sunday Chronicle (1951-1952)
Resilience of NJ Transit assets to climate impacts
No full textFirst Environment developed this report under the guidance of New Jersey Transit to determine the potential risks of weather related events and impacts on its stationary assets. This research includes a survey of current reports and research on the topic; identifies and maps specific impacts to New Jersey Transit assets - commuter rail, light rail and bus; compiles national and international agency efforts underway regarding Transit strategies to protect assets; determines appropriate resilience strategies for the impacts identified; provides a summary level costs and benefits for each of the resilience strategies identified; and summarizes and highlights cost effective strategies to maintain NJ TRANSIT current and planned future services. This report provides a regional overview and can be used to identify critical impacts on assets and take appropriate measures to reduce its vulnerability to extreme weather
Autopsy investigation in stillbirth
No full textThe UK has the highest rate of stillbirth in the developed world and there are more than three million stillbirths worldwide each year. With over 30 different classification systems, the rate of unexplained stillbirth varies from 15-60% despite postmortem investigation being undertaken in a number of cases. The primary aims of this project were to use a unique autopsy database to examine a large well characterised series of stillbirth autopsies to assess specific causes of death, relationships between fetal maceration, intrauterine and postmortem interval on cause of death and fetal intrauterine growth restriction as well as producing evidence based guidelines for autopsy practise and investigating the potential role of novel techniques in future stillbirth autopsy. The analysis of more than 1000 intrauterine and intrapartum fetal deaths revealed that two thirds had an unexplained cause of death. Internal examination of the fetuses provided a definitive cause of death in 1% of cases; 19% of the overall causes of death could have been diagnosed from review of the clinical circumstances and a further 18% by placental macroscopic and microscopic examination. Significant associations were found between increasing maceration and Small for Gestational Age (SGA) fetuses and that using birthweight or bodyweight alone erroneously overestimate the role of SGA as an underlying factor in stillbirth causation. Other investigations such as modified organ weight ratios may contribute to determining cause of death. Proteomic experiments proved that in principle significantly different amounts and types proteins could be successfully extracted from formalin fixed paraffin embedded stillbirth fetal tissue in different case groups, suggesting a possible future investigation into the causation of stillbirth
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Molecular cloning and functional analyses of glutathione peroxidase homologous genes from Chlorella sp NJ-18
No full textPhotosynthetic organisms often encounter oxidative stresses due to changes of environmental conditions. In this study, two glutathione peroxidase (GPX) homologous genes, namely NJ-18Gpx1 and NJ-18Gpx2, were identified in Chlorella sp. NJ-18, a single-celled green alga. The two NJ-18Gpx genes can produce 2 or 3 transcript variants by alternative splicing, predicted to encode 4 non-selenium GPX proteins (NS-GPX). Expression of the two genes was analyzed by quantitative RT-PCR in Chlorella sp. NJ-18 exposed to various treatments known to generate reactive oxygen species. Neutral red, a singlet oxygen-generating photosensitizer, significantly increased the expression of NJ-18Gpx1 within 5 h. Exposure of algal culture to UV-B for 3 h caused up-regulation of mRNA levels of NJ-18Gpx1 and NJ-18Gpx2 by 4- and 50-folds, respectively. Similar to CrGPX5 and CrGPX3 in Chlamydomonas reinhardtii, purified recombinant NJ-18GPXs showed activities of thioredoxin-dependent peroxidases that catalyze the reduction of hydrogen peroxide and organic hydroperoxides. The V-max values for NJ-18GPX1 toward different peroxides were approximately 10-fold higher than those for NJ-18GPX2. In addition, overexpression of NJ-18Gpx1 in Synechocystis sp. PCC 6803, a cyanobacterium, enhanced its tolerance to neutral red and H2O2. These results indicate that NJ-18GPXs can act as efficient peroxide scavengers protecting cells from oxidative damages in Chlorella. (C) 2012 Elsevier B.V. All rights reserved.Photosynthetic organisms often encounter oxidative stresses due to changes of environmental conditions. In this study, two glutathione peroxidase (GPX) homologous genes, namely NJ-18Gpx1 and NJ-18Gpx2, were identified in Chlorella sp. NJ-18, a single-celled green alga. The two NJ-18Gpx genes can produce 2 or 3 transcript variants by alternative splicing, predicted to encode 4 non-selenium GPX proteins (NS-GPX). Expression of the two genes was analyzed by quantitative RT-PCR in Chlorella sp. NJ-18 exposed to various treatments known to generate reactive oxygen species. Neutral red, a singlet oxygen-generating photosensitizer, significantly increased the expression of NJ-18Gpx1 within 5 h. Exposure of algal culture to UV-B for 3 h caused up-regulation of mRNA levels of NJ-18Gpx1 and NJ-18Gpx2 by 4- and 50-folds, respectively. Similar to CrGPX5 and CrGPX3 in Chlamydomonas reinhardtii, purified recombinant NJ-18GPXs showed activities of thioredoxin-dependent peroxidases that catalyze the reduction of hydrogen peroxide and organic hydroperoxides. The V-max values for NJ-18GPX1 toward different peroxides were approximately 10-fold higher than those for NJ-18GPX2. In addition, overexpression of NJ-18Gpx1 in Synechocystis sp. PCC 6803, a cyanobacterium, enhanced its tolerance to neutral red and H2O2. These results indicate that NJ-18GPXs can act as efficient peroxide scavengers protecting cells from oxidative damages in Chlorella. (C) 2012 Elsevier B.V. All rights reserved
Variations on the Author
No full text“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Novel Investigations in Sudden Unexpected Death in Infancy (SUDI)
No full textUnexplained Sudden Unexpected Death in Infancy (SUDI) is a diagnosis where a definitive cause of death cannot be ascertained. It remains the most common diagnosis in infant death at autopsy, despite the performance of a range of investigations including histology, microbiology and chemical pathology. Of all infant deaths with a demonstrable cause, infection is the most common finding. Recent research has shown that in some cases of unexplained SUDI, there is supportive evidence of an infectious process. Recent advances in diagnostic pathology include immunohistochemistry on formalin-fixed, paraffin-embedded (FFPE) tissue, proteomics and metabolomics. However, there are few techniques, which have transitioned from clinical practice into use during autopsy. Current techniques used at autopsy in cases of sudden infant death were assessed to see whether there was support for an infectious process. This included a retrospective analysis of all infant autopsies performed at a single centre over a fourteen-year period. Also, current consensus opinion was evaluated to determine areas of diagnostic difficulty. Cohort groups of infant deaths were selected for the application of novel immunohistochemical staining and proteomic analysis from FFPE tissues. The findings indicate that infection remains the commonest identifiable cause of death in SUDI, even over a 100 year time period, supported by recent demographic data. Unexplained SUDI cases were confirmed as having an increased incidence of positive blood cultures for infections of uncertain significance, including Staphylococcus aureus and Escherichia Coli. Evaluation of organ weights at autopsy demonstrated no significant associations, although the thymus was smaller in cases of infectious deaths. Blood/bile acylcarnitine levels showed differential expression in 3 different cohorts. Immunohistochemical staining revealed infectious deaths had a characteristic profile of expression including upregulated C Reactive Protein and ICAM-1. Protein expression was investigated with development of an applicable technique for usage in autopsy FFPE tissue. Subsequently, a pilot study of the utilisation of proteomics in the diagnosis of SUDI was performed with effective extraction of peptides and the identification of bacterial proteins in different cohorts. This thesis has demonstrated new techniques for the investigation of SUDI with establishment of supportive evidence for infectious deaths which are applicable for future use in autopsy cases
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