138 research outputs found
Exploring Different Levels of Stakeholder Activity in International Institutions. Late Bloomers, Regular Visitors, and Overachievers in Arctic Council Working Groups
No full textKnecht S. Exploring Different Levels of Stakeholder Activity in International Institutions. Late Bloomers, Regular Visitors, and Overachievers in Arctic Council Working Groups. In: Keil K, Knecht S, eds. Governing Arctic Change. Global Perspectives. 1st ed. Basingstoke: Palgrave Macmillan; 2017: 163-185.This chapter illustrates different ‘worlds of commitment’ with regard to how accredited observers participate in Arctic Council Working Groups, and the weight this carries for the institutional effectiveness of the body. Drawing on a dataset that covers the attendance records of Arctic Council member states, Permanent Participants, and observers for the period from 1998 until 2015, the author shows large variation in how stakeholders make use of their right to participate in Working Group meetings. The chapter further seeks to explain the reasons for this variation by comparing the cases of three state observers, namely Germany (the late bloomer), the Netherlands (the regular visitor), and South Korea (the overachiever)
Response to Letter to Editor: “Is There a Potential Benefit to Increased Irrigation Channels During Radiofrequency Ablation? Results From a Two-Center Prospective Randomized Study”
No full textFLWINinfo:eu-repo/semantics/publishe
90 años del artículo de Theodoro Knecht sobre el “karst” en la revista Geografía de la Asociación Brasileña de Geógrafos
No full textIntroduction. This article revisits the trajectory of Theodoro Knecht, author of the paper Formações Estruturaes, Particularmente Karsticas do Município de Apiaí (Estado de S. Paulo), published in 1935 in the first volume of the journal Geografia, by the Associação dos Geógrafos Brasileiros (AGB). Objective. To highlight the author’s technical and intellectual contribution to the emergence of academic Geography in Brazil. Methodology. A bibliographic review of primary and secondary sources, focusing on the analysis of the historical and scientific context of the topic. Results. The analysis of the text and the investigation of historical sources revealed that the connection between Knecht’s experience in mineral research—especially in the Vale do Ribeira—and his practical and theoretical knowledge of karst are reflected in the consolidation of university Geography established in 1934 at the University of São Paulo. Conclusion. Revisiting Knecht’s article ninety years after its publication by the AGB allows us to reaffirm its foundational importance for scientific Geography in Brazil.Introducción. Este artículo revisita la trayectoria de Theodoro Knecht, autor del texto Formações Estruturaes, Particularmente Karsticas do Município de Apiaí (Estado de S. Paulo), publicado en 1935 en el primer volumen de la revista Geografia, de la Associação dos Geógrafos Brasileiros (AGB). Objetivo. Destacar la contribución técnica e intelectual del autor al surgimiento de la Geografía académica en Brasil. Metodología. Revisión bibliográfica de fuentes primarias y secundarias, con enfoque en el análisis del contexto histórico y científico del tema. Resultados. El análisis del texto y la investigación de las fuentes históricas demostraron que la articulación entre la experiencia en investigación mineral, especialmente en el Vale do Ribeira, y el conocimiento práctico y teórico del karst presentado por Knecht se reflejan en la consolidación de la Geografía universitaria creada en 1934 en la Universidad de São Paulo. Conclusión. Revisitar el artículo de Knecht, noventa años después de su publicación por la AGB, permite reafirmar su importancia fundacional para la Geografía científica brasileña.Introdução. Este artigo revisita a trajetória de Theodoro Knecht, autor do texto Formações Estruturaes, Particularmente Karsticas do Município de Apiaí (Estado de S. Paulo), publicado em 1935 no primeiro volume da revista Geografia, da Associação dos Geógrafos Brasileiros (AGB). Objetivo. Evidenciar a contribuição técnica e intelectual do autor para o advento da Geografia acadêmica no Brasil. Metodologia. Revisão bibliográfica de fontes primárias e secundárias, com enfoque na análise do contexto histórico e científico do tema. Resultados. A análise do texto e a investigação das fontes históricas mostraram que a articulação entre a experiência em pesquisa mineral, especialmente no Vale do Ribeira, e o conhecimento prático e teórico do carste apresentados por Knecht estão refletidos na consolidação da Geografia universitária criada em 1934 na Universidade de São Paulo. Conclusão. Revisitar o artigo de Knecht, noventa anos após sua publicação pela AGB, permite reafirmar sua importância fundadora para a Geografia científica brasileira
Author response: Ionotropic Receptor-dependent moist and dry cells control hygrosensation in Drosophila
No full textInsects use hygrosensation (humidity sensing) to avoid desiccation and, in vectors such as mosquitoes, to locate vertebrate hosts. Sensory neurons activated by either dry or moist air ('dry cells' and 'moist cells') have been described in many insects, but their behavioral roles and the molecular basis of their hygrosensitivity remain unclear. We recently reported that Drosophila hygrosensation relies on three Ionotropic Receptors (IRs) required for dry cell function: IR25a, IR93a and IR40a (Knecht et al., 2016). Here, we discover Drosophila moist cells and show that they require IR25a and IR93a together with IR68a, a conserved, but orphan IR. Both IR68a- and IR40a-dependent pathways drive hygrosensory behavior: each is important for dry-seeking by hydrated flies and together they underlie moist-seeking by dehydrated flies. These studies reveal that humidity sensing in Drosophila, and likely other insects, involves the combined activity of two molecularly related but neuronally distinct hygrosensing systems
When Differential Pacing Is Not Enough to Assess Mitral Isthmus Block: Importance of the Pacing Threshold.
No full textJOURNAL ARTICLEFLWINinfo:eu-repo/semantics/publishe
Long-term clinical benefits of pulsed field ablation in paroxysmal atrial fibrillation: subanalyses from the multicenter inspIRE trial :
No full textThe authors thank all inspIRE study (Study for Treatment of Paroxysmal Atrial Fibrillation [PAF] by Pulsed Field Ablation [PFA] System With Irreversible Electroporation [IRE]) personnel and patients for their valuable participation in this trial. The authors thank the following individuals for their efforts in trial execution, statistical analysis, and input during the development of this article: Christina Kaneko, Jaclyn Alcazar, Guixia Huang, Stephen Hynes, Ramona Wu, Carmen Rousseeuw, Sarah Rabau, and Nathalie Marcours. Michelle Hughes, PhD, of Lumanity Communications Inc, provided medical writing and editorial support, funded by Biosense Webster, Inc, under the direction of the authors. The inspIRE Trial Investigators: Luigi Di Biase, Jim Hansen, Sebastien Knecht, Georgios Kollias, Peter Lukac, Andrea Natale, Jan Petru, and Thomas Phlips
Overfitting with Forward Stepwise Logistic Regression 6. Performing Organization Code 7. Author(s) 8. Performing Organization Report No.
No full textThis document is disseminated under the sponsorship o
A tablet-computer app displaying runway winds
No full textWe tested variants of a mobile meteorological tablet-computer application designed to help general aviation (GA) pilots land aircraft more safely under windy conditions. This “app” compared METAR runway wind information in several graphical and textual formats. Study 1 tested 25 GA pilots on 18 runway wind scenarios. Graphical METARs depicted the runway with a large arrow at 90°, representing the crosswind speed component, and a second arrow parallel to the runway, representing the headwind/tailwind component. We hypothesized that eliminating the need for complex mental calculation of wind components would increase speed and/or accuracy of information processing. Study 2 tested 17 pilots on 24 scenarios, employing the same basic method, but enhanced by color-coding the wind-component arrows according to each pilot’s previously stated maximums for landing wind risk-tolerance. Both studies showed that runwayrelative, two-arrow wind component depictions were significantly fastest and most efficient. Pilots unanimously preferred graphical displays over textual
Dual energy for pulmonary vein isolation using focal ablation technology integrated with a three-dimensional mapping system: SmartfIRE 12-month results
No full textAims The multicentre, single-arm SmartfIRE study assessed the safety and effectiveness of the novel dual-energy THERMOCOOL SMARTTOUCH SF (DE STSF) contact-force sensing catheter with multimodality generator to deliver radiofrequency (RF) and unipolar biphasic pulsed field (PF) ablation. Three-month follow-up showed a 100% acute success rate with an acceptable safety profile. Results at 12 months postablation are summarized here.Methods and results Patients with symptomatic paroxysmal atrial fibrillation underwent pulmonary vein isolation with the recommendation of PF ablation at posterior/inferior and RF ablation at the anterior/ridge/carina segments. The 12-month effectiveness endpoint was freedom from documented symptomatic and asymptomatic atrial arrhythmia on or off antiarrhythmic therapy (assessed by electrocardiogram, remote arrhythmia monitoring, and 24-h Holter), including acute procedural failures. Safety was assessed as the incidence of serious adverse events (SAEs) related to device and/or procedure. Quality of life was evaluated via Atrial Fibrillation Effect on Quality-of-Life (AFEQT) scores, and healthcare utilization was assessed as hospitalization for cardiovascular events and antiarrhythmic drug (AAD) use. Of 149 patients enrolled, 140 had the study catheter inserted (safety population analysis set), and 136 met the eligibility criteria and had ablation energy delivered (per-protocol analysis set). Freedom from symptomatic and asymptomatic atrial arrhythmia at 12 months was 71.5% (84.2% when using standard-of-care monitoring only). The clinical success rate (freedom from symptomatic arrhythmia) was 86.4%, and single procedural success was 81.0% (n = 136). The rate of device- and/or procedure-related SAEs was 3.6% (5/140 patients; two cardiac tamponades, two pulmonary vein stenosis, one anaphylactic shock). At 12 months, the overall AFEQT score increased by a median 26.9 points vs. baseline. Cardiovascular hospitalization rate reduced from 20.1 to 11.9% during the 12 months before vs. after ablation, respectively. The use of Class I/III AAD decreased from 60.3% at baseline to 23.9% at 6-12 months postablation. Post hoc analysis showed that patients with high adherence to recommended inter-tag distance and PF/RF index during ablation (n = 47) had a 12-month freedom from atrial arrhythmia recurrence of 86.9%, while the remaining patients (n = 88) had a rate of 64.0%.Conclusion The 12-month follow-up of the SmartfIRE study demonstrated the effectiveness, safety, and healthcare benefits of ablation using the DE STSF platform.Clinical Trial Registration ClinicalTrials.gov Identifier: NCT05752487 (https://clinicaltrials.gov/study/NCT05752487)Clinical Trial Registration ClinicalTrials.gov Identifier: NCT05752487 (https://clinicaltrials.gov/study/NCT05752487)Funding
This study was supported by Biosense Webster, Inc., part of Johnson & Johnson MedTech.
Acknowledgements
We thank all SmartfIRE study personnel and patients for their valuable participation in this trial. We thank the following individuals for their efforts in trial execution, statistical analysis, and input during the development of this
article: Sarah Rabau, Liesbeth Vanderlinden, Li Wan, Jennifer Maffre, Guixia Huang, Farid Jamshidian, Yanmin Wang, Erin Rogers, and Swati Trivedi. Medical writing and editorial assistance was provided in accordance with
Good Publication Practice guidelines by Michelle Hughes, PhD, of Lumanity Communications, Inc. (Yardley, PA, USA), under the guidance of the authors, and was funded by Biosense Webster, Inc. (Irvine, CA, USA), part of Johnson & Johnson MedTech
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