244 research outputs found
Black Fashion Designers Symposium: June Ambrose in conversation with Carly Cushnie and Michelle Ochs
No full textJune Ambrose in conversation with Carly Cushnie and Michelle Ochs at The Museum at FIT's annual fashion symposium, Black Fashion Designers, held on Monday, February 6, 2017. The one-day symposium featured talks by designers, models, journalists, and scholars on African diasporic culture and fashion.June Ambrose is a celebrity stylist and designer whose clients include Sean Combs, Jay Z, Alicia Keys, and Gabrielle Union. She is author of the book Effortless Style.Carly Cushnie and Michelle Ochs founded their brand Cushnie et Ochs in 2008, creating collections that juxtapose bold sensuality with minimalist sophistication
Alterations of alveolar type II cells and intraalveolar surfactant after bronchoalveolar lavage and perfluorocarbon ventilation. An electron microscopical and stereological study in the rat lung
No full textAbstract Background Repeated bronchoalveolar lavage (BAL) has been used in animals to induce surfactant depletion and to study therapeutical interventions of subsequent respiratory insufficiency. Intratracheal administration of surface active agents such as perfluorocarbons (PFC) can prevent the alveolar collapse in surfactant depleted lungs. However, it is not known how BAL or subsequent PFC administration affect the intracellular and intraalveolar surfactant pool. Methods Male wistar rats were surfactant depleted by BAL and treated for 1 hour by conventional mechanical ventilation (Lavaged-Gas, n = 5) or partial liquid ventilation with PF 5080 (Lavaged-PF5080, n = 5). For control, 10 healthy animals with gas (Healthy-Gas, n = 5) or PF5080 filled lungs (Healthy-PF5080, n = 5) were studied. A design-based stereological approach was used for quantification of lung parenchyma and the intracellular and intraalveolar surfactant pool at the light and electron microscopic level. Results Compared to Healthy-lungs, Lavaged-animals had more type II cells with lamellar bodies in the process of secretion and freshly secreted lamellar body-like surfactant forms in the alveoli. The fraction of alveolar epithelial surface area covered with surfactant and total intraalveolar surfactant content were significantly smaller in Lavaged-animals. Compared with Gas-filled lungs, both PF5080-groups had a significantly higher total lung volume, but no other differences. Conclusion After BAL-induced alveolar surfactant depletion the amount of intracellularly stored surfactant is about half as high as in healthy animals. In lavaged animals short time liquid ventilation with PF5080 did not alter intra- or extracellular surfactant content or subtype composition.</p
"Exploring Our Sexualities" - Noted Author and Activist Robyn Ochs to Present Workshop and Interactive Presentation at U of M Crookston on Wednesday, April 22, 2009
No full textTollefson, Elizabeth. (2009). "Exploring Our Sexualities" - Noted Author and Activist Robyn Ochs to Present Workshop and Interactive Presentation at U of M Crookston on Wednesday, April 22, 2009. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/222053
Verbesserung der automatischen Transkription von englischen Wörtern in deutschen Vorlesungen
No full textan electron microscopical and stereological study in the rat lung ; Research
No full textBackground: Repeated bronchoalveolar lavage (BAL) has been used in animals to induce surfactant depletion and to study therapeutical interventions of subsequent respiratory insufficiency. Intratracheal administration of surface active agents such as perfluorocarbons (PFC) can prevent the alveolar collapse in surfactant depleted lungs. However, it is not known how BAL or subsequent PFC administration affect the intracellular and intraalveolar surfactant pool. Methods: Male wistar rats were surfactant depleted by BAL and treated for 1 hour by conventional mechanical ventilation (Lavaged-Gas, n = 5) or partial liquid ventilation with PF 5080 (Lavaged-PF5080, n = 5). For control, 10 healthy animals with gas (Healthy-Gas, n = 5) or PF5080 filled lungs (Healthy-PF5080, n = 5) were studied. A design-based stereological approach was used for quantification of lung parenchyma and the intracellular and intraalveolar surfactant pool at the light and electron microscopic level.Results: Compared to Healthy-lungs, Lavaged-animals had more type II cells with lamellar bodies in the process of secretion and freshly secreted lamellar body-like surfactant forms in the alveoli. The fraction of alveolar epithelial surface area covered with surfactant and total intraalveolar surfactant content were significantly smaller in Lavaged-animals. Compared with Gas-filled lungs, both PF5080-groups had a significantly higher total lung volume, but no other differences. Conclusion: After BAL-induced alveolar surfactant depletion the amount of intracellularly stored surfactant is about half as high as in healthy animals. In lavaged animals short time liquid ventilation with PF5080 did not alter intra- or extracellular surfactant content or subtype composition
Supplemental Material, sj-docx-3-cpt-10.1177_10742484211054620 - Impact of Homoarginine on Myocardial Function and Remodeling in a Rat Model of Chronic Renal Failure
No full textSupplemental Material, sj-docx-3-cpt-10.1177_10742484211054620 for Impact of Homoarginine on Myocardial Function and Remodeling in a Rat Model of Chronic Renal Failure by Vitali Koch, Christophe Weber, Johannes H. Riffel, Kristina Buchner, Sebastian J. Buss, Selina Hein, Derliz Mereles, Marco Hagenmueller, Christian Erbel, Winfried März, Christian Booz, Moritz H. Albrecht, Thomas J. Vogl, Norbert Frey, Stefan E. Hardt and Marco Ochs in Journal of Cardiovascular Pharmacology and Therapeutics</p
Exogenous surfactant application in a rat lung ischemia reperfusion injury model: effects on edema formation and alveolar type II cells
No full textAbstract Background Prophylactic exogenous surfactant therapy is a promising way to attenuate the ischemia and reperfusion (I/R) injury associated with lung transplantation and thereby to decrease the clinical occurrence of acute lung injury and acute respiratory distress syndrome. However, there is little information on the mode by which exogenous surfactant attenuates I/R injury of the lung. We hypothesized that exogenous surfactant may act by limiting pulmonary edema formation and by enhancing alveolar type II cell and lamellar body preservation. Therefore, we investigated the effect of exogenous surfactant therapy on the formation of pulmonary edema in different lung compartments and on the ultrastructure of the surfactant producing alveolar epithelial type II cells. Methods Rats were randomly assigned to a control, Celsior (CE) or Celsior + surfactant (CE+S) group (n = 5 each). In both Celsior groups, the lungs were flush-perfused with Celsior and subsequently exposed to 4 h of extracorporeal ischemia at 4°C and 50 min of reperfusion at 37°C. The CE+S group received an intratracheal bolus of a modified natural bovine surfactant at a dosage of 50 mg/kg body weight before flush perfusion. After reperfusion (Celsior groups) or immediately after sacrifice (Control), the lungs were fixed by vascular perfusion and processed for light and electron microscopy. Stereology was used to quantify edematous changes as well as alterations of the alveolar epithelial type II cells. Results Surfactant treatment decreased the intraalveolar edema formation (mean (coefficient of variation): CE: 160 mm3 (0.61) vs. CE+S: 4 mm3 (0.75); p 3 (0.90) vs. CE+S: 0 mm3; p 3 (0.39) vs. CE+S: 268 mm3 (0.43); p 3(0.10)) and CE+S (481 μm3(0.10)) compared with controls (323 μm3(0.07); p Conclusion Intratracheal surfactant application before I/R significantly reduces the intraalveolar edema formation and development of atelectases but leads to an increased development of peribronchovascular edema. Morphological changes of alveolar type II cells due to I/R are not affected by surfactant treatment. The beneficial effects of exogenous surfactant therapy are related to the intraalveolar activity of the exogenous surfactant.</p
Supplemental Material, sj-docx-1-cpt-10.1177_10742484211054620 - Impact of Homoarginine on Myocardial Function and Remodeling in a Rat Model of Chronic Renal Failure
No full textSupplemental Material, sj-docx-1-cpt-10.1177_10742484211054620 for Impact of Homoarginine on Myocardial Function and Remodeling in a Rat Model of Chronic Renal Failure by Vitali Koch, Christophe Weber, Johannes H. Riffel, Kristina Buchner, Sebastian J. Buss, Selina Hein, Derliz Mereles, Marco Hagenmueller, Christian Erbel, Winfried März, Christian Booz, Moritz H. Albrecht, Thomas J. Vogl, Norbert Frey, Stefan E. Hardt and Marco Ochs in Journal of Cardiovascular Pharmacology and Therapeutics</p
Supplemental Material, sj-docx-2-cpt-10.1177_10742484211054620 - Impact of Homoarginine on Myocardial Function and Remodeling in a Rat Model of Chronic Renal Failure
No full textSupplemental Material, sj-docx-2-cpt-10.1177_10742484211054620 for Impact of Homoarginine on Myocardial Function and Remodeling in a Rat Model of Chronic Renal Failure by Vitali Koch, Christophe Weber, Johannes H. Riffel, Kristina Buchner, Sebastian J. Buss, Selina Hein, Derliz Mereles, Marco Hagenmueller, Christian Erbel, Winfried März, Christian Booz, Moritz H. Albrecht, Thomas J. Vogl, Norbert Frey, Stefan E. Hardt and Marco Ochs in Journal of Cardiovascular Pharmacology and Therapeutics</p
Myocardial mechanics in dilated cardiomyopathy: prognostic value of left ventricular torsion and strain
No full textAbstract Background Data on the prognostic value of left ventricular (LV) morphological and functional parameters including LV rotation in patients with dilated cardiomyopathy (DCM) using cardiovascular magnetic resonance (CMR) are currently scarce. In this study, we assessed the prognostic value of global longitudinal strain (GLS), global circumferential strain (GCS), global radial strain (GRS) and LV torsion using CMR feature tracking (FT). Methods CMR was performed in 350 DCM patients and 70 healthy subjects across 5 different European CMR Centers. Myocardial strain parameters were retrospectively assessed from conventional balanced steady-state free precession cine images applying FT. A combined primary endpoint (cardiac death, heart transplantation, aborted sudden cardiac death) was defined for the assessment of clinical outcome. Results GLS, GCS, GRS and LV torsion were significantly lower in DCM patients than in healthy subjects (all p < 0.001). The primary endpoint occurred in 59 (18.7%) patients [median follow-up 4.2 (2.0–5.6) years]. In the univariate analyses all strain parameters showed a significant prognostic value (p < 0.05). In the multivariate model, LV strain parameters, particularly GLS provided an incremental prognostic value compared to established CMR parameters like LV ejection fraction and late gadolinium enhancement. A scoring model including six categorical variables of standard CMR and strain parameters differentiated further risk subgroups. Conclusion LV strain assessed with CMR FT has a high prognostic value in patients with DCM, surpassing routine and dedicated functional parameters. Thus, CMR strain imaging may contribute to the improvement of risk stratification in DCM
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