23 research outputs found
The international HAE guideline under real-life conditions: From possibilities to limits in daily life - current real-world data of 8 German angioedema centers
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Management von kongenitalen Riesennävi beim Säugling durch Exzisionen in Lokalanästhesie
No full textCase report: successful treatment of a novel variant of CARD14-mutated juvenile Pityriasis rubra pilaris with ixekizumab
No full textPityriasis rubra pilaris is a rare inflammatory papulosquamous skin disease without any approved treatment options. Variants in the CARD14 (caspase recruitment domain family member 14) gene have been identified to play a role in the pathophysiology of atypical juvenile PRP by activating the IL-23/IL-17A cytokine axis, highlighting this pathway as a potential target of therapy. Here, we present a case of successful treatment with ixekizumab, a humanized monoclonal anti-IL-17A antibody, in an atypical juvenile PRP (type V) patient with a novel variant of CARD14 mutation
40Ar/39Ar dating of Quaternary lavas in northwest Iran: constraints on the landscape evolution and incision rates of the Turkish-Iranian plateau
No full textWe report five new <sup>40</sup>Ar/<sup>39</sup>Ar ages for basaltic lavas in the Maku region of northwest Iran, between ca. 1.87 and 0.40 Ma, which help constrain the tectonic and landscape evolution of this part of the Turkish–Iranian plateau. Flows originated from the composite volcanoes Ararat (Agri Dagi), Tendürek and Yigit Dagi, in eastern Turkey (Anatolia). These volcanoes are within the Turkish–Iranian plateau, which is a consequence of the Arabia–Eurasia collision, but has a poorly constrained evolution and surface uplift history. Current plateau elevations are typically 1.5–2 km, and relief between non-volcanic summits and basins is typically on the scale of ∼1 km. Samples are from flows that passed along pre-existing river valleys. Gorges were cut by re-established rivers after the eruptions, but the great majority of the local relief (∼95 per cent) lies above the sampled flows and so most likely pre-dates the volcanism. Gorge depths and lava ages allow local Quaternary fluvial incision rates to be calculated, which are ∼0.01 to 0.05 mm yr−1. These rates imply slow surface uplift of this part of the Turkish–Iranian plateau during the Quaternary. We therefore constrain the generation of the great majority of relief in the study area to be pre-Quaternary, and caused by the tectonic construction of the plateau, rather than a subcrustal origin related to the Quaternary magmatism
