1,720,978 research outputs found
Innovations en imagerie TEP-TDM dans le cancer du sein
No full textBreast cancer is the most common cancer in women around the world and the first leading cause of cancer death in women in France (InCa, 2022). A current challenge is the early and personalized management based on powerful diagnostic tools and associated biomarkers. Among these, 18F-Fluoro-Deoxy-Glucose Positron Emission Tomography with Computed Tomography ([18F]FDG PET/CT) imaging currently plays a crucial role in determining the extent of disease and in ensuring that the treatment is effective. The arrival of new therapeutic molecules, the better understanding of key pathophysiologic mechanisms and the availability of more specific radiotracers ([68Ga]FAPI and [18F]FES) in nuclear medicine open up many opportunities for PET/CT imaging.In this context, the objective of the thesis work is threefold: 1) To identify biomarkers extracted from [18F]FDG PET/CT for the prediction of novel therapies efficacy in breast cancer patients. 2) To decipher the relationship between the metabolism of tumoral and non-tumoral tissues (spleen and bone marrow) measured using [18F]FDG PET/CT with the properties / behavior of the tumor and of its microenvironment, using pathology and biology. 3) To determine how PET imaging using [68Ga]FAPI and [18F]FES could optimize the therapeutic management of breast cancer patients.Le cancer du sein est le 1er cancer chez la femme dans le monde et la 1ère cause de décès par cancer chez la femme en France (chiffres InCa, 2022). Un des défis actuels concerne la prise en charge précoce et personnalisée basée sur des outils performants. Parmi eux, l'imagerie par Tomographie par Emission de Positons (TEP) couplée à la Tomodensitométrie (TDM) avec le Fluoro-Deoxy-Glucose marqué au Fluor-18 ([18F]FDG) joue déjà un rôle fondamental pour connaître l'étendue de la maladie dès son diagnostic et, ultérieurement, pour déterminer si le traitement est efficace. L'arrivée de nouvelles molécules thérapeutiques, la meilleure compréhension de certains mécanismes physiopathologiques clés et l'avènement de radiotraceurs plus spécifiques en médecine nucléaire ([68Ga]FAPI et [18F]FES) ouvrent de nombreuses perspectives en imagerie TEP/TDM.Dans ce contexte, l'objectif du travail de thèse sera triple : 1) Identifier des biomarqueurs extraits de l'imagerie TEP/TDM au [18F]FDG pour prédire l'efficacité des nouveaux traitements dans le cancer du sein. 2) Décrypter la relation du métabolisme des tissus tumoraux et non-tumoraux (rate et moelle osseuse en particulier) visualisé en TEP/TDM au [18F]FDG avec la tumeur et son microenvironnement, sur le plan histologique et moléculaire. 3) Déterminer en quoi l'imagerie TEP avec le [68Ga]FAPI et le [18F]FES peut améliorer la prise en charge thérapeutique des patientes avec cancer du sein
Innovations en imagerie TEP-TDM dans le cancer du sein
No full textBreast cancer is the most common cancer in women around the world and the first leading cause of cancer death in women in France (InCa, 2022). A current challenge is the early and personalized management based on powerful diagnostic tools and associated biomarkers. Among these, 18F-Fluoro-Deoxy-Glucose Positron Emission Tomography with Computed Tomography ([18F]FDG PET/CT) imaging currently plays a crucial role in determining the extent of disease and in ensuring that the treatment is effective. The arrival of new therapeutic molecules, the better understanding of key pathophysiologic mechanisms and the availability of more specific radiotracers ([68Ga]FAPI and [18F]FES) in nuclear medicine open up many opportunities for PET/CT imaging.In this context, the objective of the thesis work is threefold: 1) To identify biomarkers extracted from [18F]FDG PET/CT for the prediction of novel therapies efficacy in breast cancer patients. 2) To decipher the relationship between the metabolism of tumoral and non-tumoral tissues (spleen and bone marrow) measured using [18F]FDG PET/CT with the properties / behavior of the tumor and of its microenvironment, using pathology and biology. 3) To determine how PET imaging using [68Ga]FAPI and [18F]FES could optimize the therapeutic management of breast cancer patients.Le cancer du sein est le 1er cancer chez la femme dans le monde et la 1ère cause de décès par cancer chez la femme en France (chiffres InCa, 2022). Un des défis actuels concerne la prise en charge précoce et personnalisée basée sur des outils performants. Parmi eux, l'imagerie par Tomographie par Emission de Positons (TEP) couplée à la Tomodensitométrie (TDM) avec le Fluoro-Deoxy-Glucose marqué au Fluor-18 ([18F]FDG) joue déjà un rôle fondamental pour connaître l'étendue de la maladie dès son diagnostic et, ultérieurement, pour déterminer si le traitement est efficace. L'arrivée de nouvelles molécules thérapeutiques, la meilleure compréhension de certains mécanismes physiopathologiques clés et l'avènement de radiotraceurs plus spécifiques en médecine nucléaire ([68Ga]FAPI et [18F]FES) ouvrent de nombreuses perspectives en imagerie TEP/TDM.Dans ce contexte, l'objectif du travail de thèse sera triple : 1) Identifier des biomarqueurs extraits de l'imagerie TEP/TDM au [18F]FDG pour prédire l'efficacité des nouveaux traitements dans le cancer du sein. 2) Décrypter la relation du métabolisme des tissus tumoraux et non-tumoraux (rate et moelle osseuse en particulier) visualisé en TEP/TDM au [18F]FDG avec la tumeur et son microenvironnement, sur le plan histologique et moléculaire. 3) Déterminer en quoi l'imagerie TEP avec le [68Ga]FAPI et le [18F]FES peut améliorer la prise en charge thérapeutique des patientes avec cancer du sein
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
The Role of Cost-Effectiveness Analysis in Patient-Centered Cancer Care in the Era of Precision Medicine
Full text linkOver the last few decades, changes in diagnostic and treatment paradigms have greatly advanced cancer care and improved outcomes [...
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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